Sarah Marzi
Senior Lecturer and UK DRI Group Leader at King's College London | Epigenetic regulation in neurodegenerative diseases | kcl.ac.uk/people/sarah-marzi
- 📣 Exciting PhD opportunities in our new programme in 🧬Genome Data Science at @kingscollegelondon.bsky.social! Come and work with me and @oliverpain.bsky.social on APOE penetrance and modifiers in #Alzheimer's. Get in touch to discuss and apply by 28 February. www.kcl.ac.uk/research/tar...
- Reposted by Sarah MarziAlso the speakers Bosiljka Tasic, Gabriel Santpere, @gioelelamanno.bsky.social, @graycamplab.bsky.social, @sarabiz86.bsky.social @gokcegroup.bsky.social @sj-marzi.bsky.social @rongfan8.bsky.social , Jose Atalaya and the computational team, @hjerling-leffler.bsky.social for their amazing talks!
- @andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS. Get in touch for any questions and apply by 2 December: my.corehr.com/pls/kclrecru...
- Delighted to speak at the @microgliaseries.bsky.social on Monday. Everyone welcome to join us online 🧬✨
- New webinar coming next MONDAY‼️ Sarah Marzi from UK Dementia Research Institute @sj-marzi.bsky.social will be our next speaker on November 3rd. Check all the information in the flyer and add it to your calendar!
- Reposted by Sarah Marzi❓ How can proteins lead to personalised Alzheimer’s treatment? Discover how Prof @sj-marzi.bsky.social team have been observing changes in the brains microglia and their responses to Alzheimer’s. Read more about Prof Marzi’s work 👉 lnkd.in/e4iaqqq9
- Reposted by Sarah MarziUK DRI @ukdri.ac.uk at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s @sj-marzi.bsky.social group to support stem cell culture, assays, and genomic work on neurodegenerative disease. Closing date: 6th October www.dementiaresearcher.nihr.ac.uk/job/research...
- Reposted by Sarah MarziFrom fellowship heartbreak to rewriting success — stories of resilience in research funding on this week’s podcast. Available to Watch on YouTube now, or wait until Monday to find it in your podcast app. youtu.be/ZbaRKM18hP0?...
- Reposted by Sarah MarziJoin us at the FENS Single-Cell & Spatial Omics Winter School with: @sarabiz86.bsky.social @rongfan8.bsky.social @gokcegroup.bsky.social @gioelelamanno.bsky.social @sj-marzi.bsky.social @jplopez-atalaya.bsky.social Ana Falcão Florian Rosenberger Gabriel Baró Bosiljka Tasic Barbara Treutlein
- ☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions! Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease: www.nature.com/articles/s41...
- In this work, led by Maria Tsalenchuk, we show that chronic exposure to the pesticide rotenone leads to different histone acetylation patterns in the substantia nigra and motor cortex. In the nigra we see striking upregulation of immune pathways.
- Conversely, we see disruption of synaptic genes in the motor cortex. These results suggest reasons why neurons in the nigra may be particularly vulnerable in Parkinson's disease and why we see impairments in synaptic plasticity in the motor cortex.
- It has been and continues to be an excellent collaboration and many thanks go to the brilliant team: Maria Tsalenchuk, Kyle Farmer, Sandra Castro, Abigail Scheirer, Yuqian Ye, Tim Greenamyre and Emily Rocha 🙏 @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
- Reposted by Sarah MarziCells in key brain regions involved in Parkinson’s retain a ‘memory’ of pesticide exposure that disrupts gene expression🧬 Research by @sj-marzi.bsky.social & colleagues unlocks understanding of the mechanisms behind the role of pesticide exposure in Parkinson’s👉 buff.ly/1F16eUB
- Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.
- Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻
- Registration is now OPEN for the 11th Canadian Conference on Epigenetics! The annual meeting will be held November 12-15, 2025 at the Banff Centre in Banff, Alberta. You can register and find out more information at our website: event.fourwaves.com/ceehrc2025
- Reposted by Sarah MarziExcited to share that a chapter of my PhD has just been published in Nature Communications! We profiled the transcriptomic and chromatin landscapes of microglia expressing the different APOE variants, which were xenografted into the brains of an Alzheimer's disease (AD) mouse model 🧠🧬 1/n
- Reposted by Sarah MarziThe APOE gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles. New research led by @sj-marzi.bsky.social offers insight into how the different versions of APOE affect microglia👉https://buff.ly/pyFh7jy
- How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
- We studied human microglia harbouring the different APOE variants, xenografted into an Alzheimer's mouse model. Our results suggest that functions including cellular motility, inflammatory immune response and phagocytosis are directly affected by the APOE isoforms.
- Importantly, some of the protective effects of APOE2 on immune functioning seem to be driven through increased DNA binding of vitamin D receptor, potentially opening up new avenues to explore therapeutic intervention.
- Huge thanks and congrats to the wonderful lead author @kittybmurphy.bsky.social and all fantastic team members here and from the De Strooper and @mancusorenzo.bsky.social labs. So grateful to the @alzassociation.bsky.social and all funders for supporting us.
- So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research!
- And just like that, 5 years in the Marzi lab @sj-marzi.bsky.social have come to an end. Couldn’t have asked for a better team ✨ Super excited to say, I’m switching fields and will be working with ancient human genomes in the Skov lab @lauritsskov.bsky.social in Copenhagen 🇩🇰
- Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations across brain diseases👇🏻
- Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨
- A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾 journals.plos.org/plosgenetics... More to come from Aydan soon!
- We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". www.cell.com/cell-reports... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social
- Led by the brilliant @kittybmurphy.bsky.social we developed CHAS, featuring two complimentary algorithms to estimate cell type proportions in bulk histone acetylation data and infer cell type specific signatures associated with different brain conditions.
- We show that there are widespread epigenetic differences in oligodendrocytes associated with Alzheimer's disease.
- Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻
- Reposted by Sarah MarziWonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠
- Reposted by Sarah MarziI am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...
- My FOMO of missing #ADPD2025 is at least partially alleviated by knowing that our team is super well represented by our brilliant PhD student Paulina. Check out her awesome poster on cell type specific histone acetylation in #Alzheimer's disease brain and say hi (poster 160) 🧠🧬
- Reposted by Sarah MarziNew study by IoPPN researcher Dr Sarah Marzi in @naturecomms.bsky.social offers a new set of guidelines for designing epigenetic studies, based on a new technique, CUT&Tag, which analyse a type of gene regulation mechanism #neuroskyence #AcademicSky www.kcl.ac.uk/news/guideli...
- Reposted by Sarah MarziWant to know how CUT&Tag works compared to ChIP-seq for studying epigenetic changes in cells and tissues?🧬 @sj-marzi.bsky.social systematically compares the new method to the existing standard, providing useful guidelines for others planning epigenetic studies 👉https://buff.ly/KFSGkzr
- We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...
- For an thread run down, check out our post on the most recent version of the preprint: bsky.app/profile/sj-m...
- Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!
- Reposted by Sarah MarziOK, I'm not going to say a word about this. Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place. www.nature.com/articles/s41...
- When you get your resident gamer to build the workstation for your @nanoporetech.com sequencer 😎 Yes, we definitely need all those colourful lights ⚡⚡⚡
- The highlight of #AAIC APOE and lipid biology? @liddelowsa.bsky.social and @oihaneuh.bsky.social seem to think so! 🥰🦭
- Reposted by Sarah MarziI am very excited to host Dr Sarah Marzi @sj-marzi.bsky.social in our virtual seminar series 'The 3D Regulatory Genome' for her talk on "Epigenetic regulation of environmental and genetic risk in neurodegenerative diseases" 📅 March 13th 2025 ⏰ 4 pm GMT Join us at: us02web.zoom.us/webinar/regi...
- Just one day left to apply as computational genomics postdoc in our lab. Apply by tomorrow, 8 of March: my.corehr.com/pls/coreport...
- A real pleasure to examine this excellent thesis! Huge congrats to the freshly baked doctor Eleonore, and to her awesome supervisors Jo and Nurun 👏🏻🎉🧠
- Congratulations to my first Imperial PhD student Eleonore Schneegans! It's been a pleasure supervising you with Nurun Fancy and Paul Matthews. And thanks to the amazing examiners @sj-marzi.bsky.social and @ppetra.bsky.social. Pretty much an all woman dream team 😍
- Reposted by Sarah Marzi📢 Next up in "The 3D Regulatory Genome" Series: @sj-marzi.bsky.social on "Epigenetic Regulation in Neurodegenerative Diseases" - exploring how epigenetics link genetic variants & environment to Alzheimer's/Parkinson's. Join us! Register: us02web.zoom.us/webinar/regi... #Neuroscience #Epigenetics
- Reposted by Sarah MarziExciting new role for a Computational Genomics Research Associate in the lab of @sj-marzi.bsky.social at the UK DRI at King's! Lead projects exploring the epigenome and transcriptome of brain cells in neurodegenerative diseases 🧠 🗓️ Deadline: 08 March 2025 Full info & to apply 👉 shorturl.at/fk7jS
- The advert is officially live and you can apply online here: tinyurl.com/yd5bsvfb
- 📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell (epi-)genomics, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠
- Reposted by Sarah MarziExcellent explainer by @philipcball.bsky.social on why now more than ever scientists need to resist the logic of "anticipatory obedience" www.chemistryworld.com/opinion/scie...
- Reposted by Sarah MarziThank you to @ukdri.ac.uk Group Leader @sj-marzi.bsky.social for joining us today & for her great talk on ‘Gene regulatory signatures of pesticide exposure in in vitro and in vivo models of #Parkinson’s disease @kavlioxford.bsky.social @oxforddpag.bsky.social @sophielfarrow.bsky.social
