Isabel Castanho, PhD
🧠Neurobiologist
🟣Alzheimer's disease & neurodegeneration
👩🏻💻Bioinformatics
🎙️Host She Has a PhD podcast
#womeninscience
📍Boston, US
💼 Junior Faculty @harvardmed.bsky.social
🇵🇹🇨🇦🇫🇮🇬🇧🇺🇸
🧘🏻♀️🎮📚📷☕🧳
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- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Looking forward to this debate! 👇🏻 Join us! 📢
- Interesting study: www.biorxiv.org/content/10.1... The authors "used Octodon degus, a rodent with exceptional longevity (up to 10 years in laboratory conditions), as a natural model of aging and neurodegenerative disease" 💡"preserved GABAergic function supports cognitive resilience in aging degus"
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- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Thrilled to share that our paper “Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease” is now out in Molecular Neurodegeneration! 👉 link.springer.com/article/10.1... #Alzheimer #Resilience #Neuroscience
- 🧠 Key takeaway: Cognitive resilience hinges on preserving excitatory-inhibitory homeostasis. Specific “surge-protector” neurons control excess firing and shield the cortex even when plaques and tangles are abundant.
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Proud to share my first co-last/co-corresponding manuscript (preprint): DNA methylation shifts in tau & Aβ mice 🧬🐁 This work started during my PhD at @exeter.ac.uk (outstanding mentor: Prof Jonathan Mill) & was led forward by Szi Kay Leung, now a superstar postdoc ⭐ www.biorxiv.org/content/10.1...
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- Now that #AAIC25 - the biggest international conference on #Alzheimers & #dementia - ended, I'm still processing all that I experienced, learned, & absorbed this past week. What a week! Looking forward to London next year, where my story as an @istaart.bsky.social ambassador began 💜 #EndAlz
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Proud of our session at #AAIC25 yesterday, "Molecular Basis of Cognitive Resilience". 💜 We really are trying to bring the field together, and I think we did a great job! 👏🏻 Thank you to the audience for making the Q&A so stimulating. 🤩 If you missed it, the recording is available online.
- @baldassogabi.bsky.social , the youngest speaker in our session - who just started her PhD - did such a great job at #AAIC25. ⭐ I'm excited to see this superstar's science & career unfold. 🤩 Well done Gabriela 👏🏻
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- Have you added the session "Molecular Basis of Cognitive Resilience" to your schedule on the #AAIC25 app yet? We have a fantastic lineup of speakers! ⭐ See you there? 🤓
- Less than 2 weeks for #AAIC25! 😱🤩💜 I'm preparing my schedule & getting excited about so many of the sessions! 😃 Have you added this one to your schedule yet? 🧠🌸 Molecular Basis of Cognitive Resilience ✨ Sunday 9 AM Room 106 ✨ I hear it's going to be great! 😉
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- Reposted by Isabel Castanho, PhD[Not loaded yet]
- POV of commuting to work this week, ahead of #AAIC25 First pic: preparing my Sunday presentation on #cognitiveresilience to #Alzheimer on my way to work Second pic: preparing slides for the Wednesday @istaart.bsky.social workshop on using #socialmedia to grow professionally
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- Less than 2 weeks for #AAIC25! 😱🤩💜 I'm preparing my schedule & getting excited about so many of the sessions! 😃 Have you added this one to your schedule yet? 🧠🌸 Molecular Basis of Cognitive Resilience ✨ Sunday 9 AM Room 106 ✨ I hear it's going to be great! 😉
- Thank you @alzassociation.bsky.social for believing in me and supporting my research 💜 #EndAlz
- 🧠 June is Alzheimer’s & Brain Awareness Month. I study why some people stay cognitively sharp despite having Alzheimer’s pathology, i.e., cognitive resilience. Instead of only asking what goes wrong, I ask: what goes right? 💡 #Alzheimers #EndAlz #AlzheimersAwarenessMonth #Resilience #Neuroscience
- Excited for #AAIC25! 💜🧠 Room 106 on Sunday will be fire! 🔥 Especially the 9:10 AM session! 😉 See you there? #EndAlz
- Reposted by Isabel Castanho, PhDDiscover how #ADPD2025 tackled everything from biomarkers to gut-brain signalling 🎧 @isabelscst.bsky.social @alzsocresearch.bsky.social @susanrohde.bsky.social @emmafgarland.bsky.social @annamallach.bsky.social @loukiakatsouri.bsky.social @ajh1269.bsky.social podfollow.com/dementia-res...
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- Reposted by Isabel Castanho, PhD[Not loaded yet]
- Anyone else #ADPD2025 ???
- #ADPD2025 was exhausting 😴 but so thrilling 🤩 The discussions really energized me! ⚡🔋 I got to chat w/ collaborators, mentors & promising students. 💬 And the city of Vienna is beautiful!! 🏛️👑🎻🖼️ I returned to Boston feeling inspired, creative & motivated. 💪🏻🙌🏻 In the pic w/ PI @winhide.bsky.social
- Great talk from @susanrohde.bsky.social @ the #cognitiveresilience session #ADPD2025 this PM! If you missed it or if you want to keep following her work, she'll be giving a talk @ the session I'm co-chairing @ #AAIC25 She'll also join me at @dementiaresearcher.bsky.social podcast on Saturday
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- On the last day of #ADPD2025 (Saturday) I'll be a guest host at the @dementiaresearcher.bsky.social podcast. 🎙️ We're still looking for a guest to join the conversation on their conference highlights. 🧠 Send me a PM if you're interested.
- Excited to be back at #ADPD2025, this time in Vienna, Austria. 🏛️🌳 Day 1 went by in a blink. ⏩ Looking forward to continue catching up with colleagues and breathing in science for the rest of the week. 🧠
- Spatial transcriptomics is revolutionizing how we understand tissue biology, but only if we can overcome its challenges. "The bottlenecks are the flip side of the coin to the excitement." Great read! #SpatialTranscriptomics #SingleCell #SystemsBiology #ComputationalBiology #SpatialOmics
- Took a few minutes before starting today to breathe in some inspiration & motivation for the day. 🧘🏻♀️ Day 1 of going back to work is going smoothly so far. 🙂 Let's hope it sets the mood for the rest of the week. 🙏🏻 #lunchbreak
- I recently came across the exciting #bioinformatics group "Boston-area Women in Bioinformatics." I'm sharing it so others can check it out. 📆 You can register for their events through their meetup webpage: www.meetup.com/boston-area-... #womenwhocode #womeninbioinformatics
- This is the best email introduction anyone has ever given me — probably my best introduction ever! 🥹 It is the perfect example of peer support that I discussed in the podcast episode linked in the email (open.spotify.com/episode/3Nve...). Simple gestures can go a long way. TY A. for the kind words.
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- Reposted by Isabel Castanho, PhD[Not loaded yet]
- ✍️ Seeing is believing: the power of role models for women and girls in science ♀️ In my recent article for @epha-eu.bsky.social I discuss why ➡️ visibility is key to fostering gender equity in STEM. ⬅️ 🔗 Read the full article: epha.org/seeing-is-be... #WomenInSTEM #WomenInScience
- Big day today‼️ 🎙️Special episode of #SheHasAPhD 🎂 1y podcast anniversary 🎉 10y of #WomenInScienceDay This episode is about reflection, growth, & what's next for #WomenInSTEM. Listen in as Ana and I discuss mentorship, leadership, & the power of peer support. ✨ 🎧 open.spotify.com/episode/3Nve...
- Just watched a cool presentation by Jeffrey Moffitt on #spatialtranscriptomics organized by @harvardbrainsci.bsky.social. Dr Moffitt started w/ an overview, promoted #MERFISH (of course), & summarized their beautiful work in #brain. But the gut bacteria work impressed me the most - SO COOL! 🤩👇
- Reposted by Isabel Castanho, PhDApply to our Pathway to Independence programme by 31 January The programme aims to support postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. journals.biologists.com/dev/pages/pi-progra… #DevBio #StemCells🧪
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- ❕Excited to share our latest findings on cognitive resilience in Alzheimer's disease (AD) ❕🧠✨ now available as a preprint on @biorxivpreprint.bsky.social! 📄 Check it out: doi.org/10.1101/2025... 1/5 #endAlz #Alzheimer #resilience #neuroscience #preprint
- Today I met w/ my awesome team behind the podcast #SheHasAPhD to discuss reflections from S1 & plans for S2. 🎙️ In Feb we'll release a special episode reviewing last year ⏮️ - stay tuned. 👀 If you haven't heard about the podcast b4, our goal is to amplify the voices of #womenleaders in #science. ♀️
