Dimitrios Davalos & Lab
Assistant Professor, Cleveland Clinic Research | Program Chair, Spring Brain Conference | Neuroscience, Neuroimmunology, Microglia, Blood-Brain Barrier, Multiphoton microscopy | MS, Stroke, AD, AUD, Epilepsy
lerner.ccf.org/neurosciences/davalos
- Reposted by Dimitrios Davalos & LabThese results hint that ageing lowers immunity in unexpected ways go.nature.com/49mahk2
- Reposted by Dimitrios Davalos & LabAcademia too often has a ‘passion first, money second’ culture. Overcoming this mindset is crucial for building a happy career go.nature.com/4bvaCCh
- Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏
- How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...
- Reposted by Dimitrios Davalos & LabWe discuss limitations of current protocols (including statistical analysis!) and provide recommendations on validating the immunicompetence of microglia in the brain organoids.
- Reposted by Dimitrios Davalos & LabEpstein-Barr virus and multiple sclerosis: A mechanism comes into focus www.sciencedirect.com/science/arti...
- Reposted by Dimitrios Davalos & LabHappy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social. www.cell.com/neuron/fullt...
- Reposted by Dimitrios Davalos & LabVery excited to be part of the organizing committee for the upcoming Neurobiology of Stress Workshop, that will happen here in Montreal next June. All the details can be found on the website 👇 www.stress2026.com
- Reposted by Dimitrios Davalos & LabThe Journal of Neuroscience has updated its policy on supplemental material. jneurosci.org/content/information…
- The brilliance of ants never seizes to amaze me! Architectural immunity: Ants alter their nest networks to prevent epidemics | Science www.science.org/doi/10.1126/...
- Reposted by Dimitrios Davalos & LabA “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories. scim.ag/428JVho
- Reposted by Dimitrios Davalos & LabFinding the tick-borne encephalitis cellular gateway could transform prevention and treatment go.nature.com/3Kqp5E9
- Reposted by Dimitrios Davalos & LabBeneficial impact of physical activity on multiple sclerosis disability progression jnnp.bmj.com/content/earl...
- Reposted by Dimitrios Davalos & LabWe are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...
- Reposted by Dimitrios Davalos & Lab#BloodBrainBarrier "microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain" Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure @cprofaci.bsky.social #Neuron 2024 www.cell.com/neuron/fullt...
- Reposted by Dimitrios Davalos & Lab2024 MS McDonald criteria now published www.thelancet.com/journals/lan...
- Reposted by Dimitrios Davalos & LabLegend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
- Reposted by Dimitrios Davalos & LabWe are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:
- Reposted by Dimitrios Davalos & LabNew research from the #StricklandLab suggests that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience
- Reposted by Dimitrios Davalos & LabHappy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
- Reposted by Dimitrios Davalos & LabMassive telescope will map the Universe and provide an evolving record of the Solar System and distant stars. go.nature.com/3HvKM4r
- Reposted by Dimitrios Davalos & LabA man with a severe speech disability is able to speak expressively and sing using a brain implant that translates his neural activity into words almost instantly. go.nature.com/4dV6avS
- Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @cp-immunity.bsky.social
- Microglia are the brain’s resident immune cells & natural phagocytes, but they stop reducing amyloid deposits from Alzheimer’s disease brains for unknown reasons. We found that microglia increase their lipid droplets and lose their phagocytic capacity with increasing Aβ exposure from amyloid plaques
- But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab.bsky.social ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease
- Emma Vidal brought our concept to life. For more info about the science produced in the @chopralab.bsky.social and ours, that inspired our geeky idea, please read the paper here: www.cell.com/immunity/abs...
- Reposted by Dimitrios Davalos & LabHappy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
- Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...
- Tremendously grateful to an amazing team of lab members and collaborators including @pryprk.bsky.social , @evipaouri.bsky.social , Palak Manchanda and Gaurav Chopra and pretty much all Chopra and Davalos Lab members for the smooth teamwork @clevelandclinic.bsky.social @purdueuniversity.bsky.social
- Reposted by Dimitrios Davalos & LabCheck out our special collection on #neuroimmunology that is online now! www.cell.com/immuni/newar... #AAI2025
- Beautiful work by @lukensjohnr.bsky.social and team out @cp-immunity.bsky.social! Congratulations to all!
- Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
- Reposted by Dimitrios Davalos & LabAlso announcing our upcoming ISFP joint congress with IFRS and the Plasminogen Activation Workshop in Corfu, Sep 28, 2025! Abstract deadline has been extended! Please join the ISFP membership to ensure your registration (includes room & board) discount! ifrs-isfpcongress2025.org
- Reposted by Dimitrios Davalos & Labp-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease. erictopol.substack.com/p/the-breakt... Here's the rundown on it. Free, open-access.
- Reposted by Dimitrios Davalos & LabZebrafish Community Cre/lox Resource website (ZebrafishCCR) will be online soon!
- Reposted by Dimitrios Davalos & LabHow does exercise and fitness promote healthy brain aging? An outstanding, comprehensive review @thelancet.bsky.social reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more www.thelancet.com/journals/lan...
- Science treats spinal muscular atrophy, a rare but lethal genetic disorder! Cool fact: The idea of giving the drug in utero came from the parents! They had already experienced a loss from this horrible disease, and wanted to try treatment before birth. The FDA approved the study for the first time!
- A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. go.nature.com/41rTube
- Reposted by Dimitrios Davalos & LabPlease share widely! We want a range of pre-doctoral trainees from both pre-clinical and psychosocial backgrounds. @rsaeducation.bsky.social @apadivision50.bsky.social
- The RSA Career Development and Training Committee is thrilled to announce that the first-ever Research Society on Alcohol 3MT Competition will be held in May for student members. To learn more and apply, visit: forms.gle/728swEWvsmcQ...
- Reposted by Dimitrios Davalos & LabHow a curious polymer could prevent blood clotting in medical implants "By using Zwitterion coated materials, authors aim to decrease the risk of blood clots and increase the lifespan of heart valves and other medical implants" www.eurekalert.org/news-release...
- Meanwhile, extraterrestrial building blocks of organic life such as nucleobases that make DNA and RNA, and a bunch of amino acids were just delivered in a canister from Bennu the Asteroid…
- Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise https://go.nature.com/4hDtGhL
- Reposted by Dimitrios Davalos & Lab📢@naturegenet.bsky.social is looking to hire a new editor! Come join our team and help publish the most exciting research in genetics and genomics! Deadline is February 5th. springernature.wd3.myworkdayjobs.com/SpringerNatu...
- Reposted by Dimitrios Davalos & LabContact me if you are interested in pursuing an independent position in Neuroscience 🧪🧠 at Achucarro @achucarro.bsky.social calls.ikerbasque.net
- Reposted by Dimitrios Davalos & LabIf you've recently purchased a portable generator due to power outages caused by the LA fires, remember to keep it outdoors at least 20ft away from your home and make sure your carbon monoxide (CO) alarms are working. 1 generator can produce as much CO as hundreds of cars and CO can kill in minutes.
- Reposted by Dimitrios Davalos & LabDid your child lose their book collection in the Los Angeles fires? Are you a teacher at a school that lost its library or your classroom library? Whether you need one book or a whole library, we can replace your books. 📚 Everyone else, please boost this post so we can connect with those in need. 🙏
- This could be really big indeed!
- Speaking words of wisdom👇 💯
- Ants up close and personal, looking far more mischievous than they are! Maybe it’s the goatee? 🤓
- I have been fascinated by how ants work together since I was a kid, and used to watch them for hours… Watch how their collective intelligence compares to that of humans dealing with the same problem!👇 Magnificent creatures!
- Ants best humans at test of collective intelligence "When people work together, they can achieve great things. But if they can’t talk, they’re not necessarily smarter than ants" Original paper www.pnas.org/doi/10.1073/... News www.science.org/content/arti...
- Reposted by Dimitrios Davalos & LabInsightful article on biomarkers & new therapies in cancer & neurological diseases. It was a pleasure discussing fibrin as a therapeutic target & biomarker. Biomarker Discovery: Revolutionizing Disease Management | Technology Networks www.technologynetworks.com/diagnostics/...
- Important protocol👇 “Antibody characterization is needed for resource validation & data reproducibility” & to believe anything you find & publish I would add?! Also 2nd: “transparent & open data sharing, enabling a community effort to identify specific antibodies for all proteins” 👏🙏to all authors!
- Poorly validated antibodies fuel the reproducibility crisis. YCharOS shares a protocol for antibody validation using KO cell lines. tinyurl.com/NP-article Read also the N&V. tinyurl.com/NP-comment Glad that our study is cited as an example for improving data quality. tinyurl.com/CSC-Letter
- Reposted by Dimitrios Davalos & LabAnnouncing the 2025 "Engram and Ensembles in Learning and Memory" meeting, at @tcddublin.bsky.social Half of speakers will be selected from abstracts submitted by trainees. Registration is open below, with discounted rates available until January 31st. event.fourwaves.com/engramsensem...
- Reposted by Dimitrios Davalos & LabLook which excellent neuroscience journal is now on Bluesky!
- Go easy on those artificial sweeteners…
- There is growing evidence that a common artificial sweetener is associated with an increased risk of heart attack and stroke. Lead researcher Dr. Stanley Hazen explains how erythritol affects the body differently than sugar. Read more: cle.clinic/4dvXHxO
- Reposted by Dimitrios Davalos & LabBeautiful review on embryonic brain vascularization!
- Lipids are a big deal in #microglia, and can tell us much about their mood! Read Priya Prakash’s and Gaurav Chopra’s team’s review below to learn more about them! 👇
- congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function. onlinelibrary.wiley.com/doi/full/10....
- Microglia-like cells differentiated from iPSCs from patients with MS display similar gene signature as MS microglia, associated with immune receptor activation, antigen presentation, complement, secretion of inflammatory cytokines & chemokines & increased phagocytosis www.biorxiv.org/content/10.1...
- Reposted by Dimitrios Davalos & Lab🧪Interested in MS research & advances in the clinic? #ACTRIMS2025 (Feb 27-Mar 1, 2025 in West Palm Beach) has a 🔥program covering hot topics & latest advances. Here's a highlight of a session focused on connections within and beyond the CNS. Registration open until Feb17: forum.actrims.org
- Reposted by Dimitrios Davalos & LabMy team is hiring at Nature Communications! If you're at #AGU24 and would like to chat about what my (great) job is like, please DM me! Associate editor (US) - $74k/yr Senior editor (US) - $91k/yr www.nature.com/naturecareer... @natureportfolio.bsky.social @naturecomms.bsky.social #academicsky
- Reposted by Dimitrios Davalos & LabOur annual "Best of JEM" series highlights some of the most exciting studies from the last 12 months. We present you with research in basic #immunology, #immunotherapy and tumor immunology, inborn errors of immunity, #neurodegeneration, & #inflammation: buff.ly/4iwWcCJ
- Reposted by Dimitrios Davalos & Labit's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)
- Reposted by Dimitrios Davalos & LabMore adults under 50 are experiencing strokes. The CDC points to higher rates of obesity, high blood pressure and diabetes as the cause. Our new study finds that half of younger patients do not come to the hospital in time for treatment. cle.clinic/3A5PgeN
- Reposted by Dimitrios Davalos & LabLots of exciting work on anti-CD19 CAR-T cell therapies in MS, including a new study led by Sasha Gupta and Bruce Cree at UCSF www.sciencedirect.com/science/arti...
- Reposted by Dimitrios Davalos & LabNature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions. springernature.wd3.myworkdayjobs.com/SpringerNatu...
- Dopamine and Serotonin: the yin the and yang behind learning behavior!
- The study demonstrates for the first time exactly how dopamine and serotonin work together -- or more precisely, in opposition -- to shape our learning behavior. #Nature Read more www.nature.com/articles/s41...
- Cell painting! www.nature.com/articles/s41...
- Reposted by Dimitrios Davalos & LabTrainees, do you have an amazing mentor (funded by NINDS)? Please nominate them for the Landis award! Your PIs also like positive feedback and nice gestures from their mentees 😊 www.ninds.nih.gov/funding/abou...
