Sander Houten
Scientist working on inborn errors of metabolism. Associate Professor at the Icahn School of Medicine at Mount Sinai. New York.
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenWhy do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...
- Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase | Science Advances www.science.org/doi/full/10....
- Reposted by Sander HoutenLoss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis @nataging.nature.com www.nature.com/articles/s43...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenOoohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Hi friends and colleagues. In these dark times for scientists and experts, I am trying to make a difference by running the NYC marathon for the propionic acidemia foundation. Please click on the link if you’re interested. fundraisers.nyrr.org/sander-houten Thanks for considering.
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Apparently I have been checking my Google Scholar profile too often 🙃 Anybody any idea why google think I am sending automated queries?
- Reposted by Sander Houten[Not loaded yet]
- Interesting, but puzzling www.nature.com/articles/s41...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenVery excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenThanks @mitodynamics.bsky.social for the fun interview and for saying it like it is: “…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
- Reposted by Sander HoutenNon-profit journals are on the critical list. The cause: academics obsession with the Nature brand, coupled with the APC $ model. Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
- Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is: “…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
- Reposted by Sander Houten[Not loaded yet]
- Looks like a cool study.
- Reposted by Sander HoutenOnline now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Interesting for those working on nonketotic hyperglycinemia.
- Propionic Acidemia is an inborn error of metabolism. It is a rare genetic disease that is included in newborn screening programs around the world. Individuals with propionic acidemia need improved treatment and a cure.
- Reposted by Sander HoutenGroundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
- Federal Court Vacates FDA Rule on Laboratory-Developed Tests www.genomeweb.com/clinical-lab...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Excellent paper by Weixiang Guo's group on the role of astrocytes in the pathophysiology of pyridoxin-dependent epilepsy due to ALDH7A1 deficiency. pubmed.ncbi.nlm.nih.gov/39980193/
- Reposted by Sander HoutenFrancis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenAfter the first measles death of a child HHS Secretary Kennedy seemed to downplay the Texas outbreak saying outbreaks were "not unusual," and the 18 kids hospitalized were "mainly for quarantine." A pediatrician on the ground said they couldn't breathe. www.nbcnews.com/health/healt...
- Reposted by Sander Houten[Not loaded yet]
- I haven't been posting often on Bluesky. And the skies are not so blue these days in the US science world. One thing we can certainly do is to show that our work is important and contributes to progress in science. Two studies that my lab contributed to were posted on bioRxiv over the last 2 weeks.
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenThis is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander HoutenHere is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria
- Reposted by Sander Houten"The science of extreme longevity continues as an immense joke." —The first man to “survive” past 110 actually died at 65. —Blue zones are a myth —Pervasive false claims about longevity and supercentenarians Gift link www.nytimes.com/2025/01/20/o...
- Reposted by Sander Houten[Not loaded yet]
- Reposted by Sander Houten[Not loaded yet]
