Great The Scientist piece: two harmful mutations can restore protein function—challenging how we view genetic risk. I share my take on the structural logic behind this and relevance to drug discovery.
My perspective
www.the-scientist.com/two-harmful-...
Original study
www.pnas.org/doi/10.1073/...
Two Harmful Variants Can Restore Protein Function
Researchers found that paired pathogenic variants can restore protein function rather than make it worse. This phenomenon could occur in four percent of human genes.
