Brendan Manning
Scientist working on signaling and metabolism in cancer, metabolic diseases, aging, and physiology. AKT-TSC-mTOR🧪
- Reposted by Brendan ManningJoin us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,
- Clear evidence from Josh Shin in our lab that mTORC1 signaling and autophagy reciprocally influence the length of primary cilia. Question remains how do changes in length affect cilia signaling and function in the largely quiescent cells comprising our brains and bodies. www.cell.com/iscience/ful...
- Just two of thousands of such stories. substack.com/home/post/p-...
- Reposted by Brendan ManningI still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
- Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
- Reposted by Brendan ManningMuch appreciated support from biotech execs and investors 🙏 www.statnews.com/2025/06/27/b...
- Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
- Ah, the pace of discovery.....Stay tuned for the tissue-specific models to follow in the coming year.
- Congrats to @harperlabhms.bsky.social and colleagues in @harvardcellbio.bsky.social for this tour de force dissection of endosomes
- Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes go.nature.com/3Z6mJ1X
- Reposted by Brendan ManningNature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes go.nature.com/3Z6mJ1X
- Reposted by Brendan ManningFrom @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more: hsph.me/mitoT2D
- Reposted by Brendan ManningFor 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
- Reposted by Brendan ManningI urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...
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- Why?
- I thank the taxpayers of the United States for supporting this research designed to better understand and treat the uncontrolled growth of cancer cells over the past 10 years.
- Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
- Reposted by Brendan ManningWith nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
- Reposted by Brendan ManningA reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
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- Reposted by Brendan ManningCheck out the new homepage for Harvard!! Love it !! www.harvard.edu
- Reposted by Brendan ManningWith support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world. Here are just three examples: hsph.harvard.edu/news/federal...
- Tough day on the slopes trying to keep up with these guys. But beats watching the news.
- There it is! The end of academic science in the US. grants.nih.gov/grants/guide...
- Last day to apply to the hub of metabolism research at Harvard.
- Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
- One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...
- Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
- Congrats to this incredible group!
- Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!
- Thanks NYG. Too bad we need 51 new players to make this team competitive again. hhttps://www.boston.com/sports/new-england-patriots/2024/12/29/new-england-patriots-nfl-draft-no-1-pick-first-giants-titans/
- But…..ok, ok, I’m convinced. Elegant and definitive. www.science.org/doi/10.1126/...
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