Harvard Molecular Metabolism
Researching the interplay between factors underlying metabolic health and disease, including diet, age, environment, and genetics, for the prevention and treatment of widespread chronic diseases. hsph.harvard.edu/department/molecula…
- Reposted by Harvard Molecular MetabolismClear evidence from Josh Shin in our lab that mTORC1 signaling and autophagy reciprocally influence the length of primary cilia. Question remains how do changes in length affect cilia signaling and function in the largely quiescent cells comprising our brains and bodies. www.cell.com/iscience/ful...
- Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
- Please read more about this publication in this article in the Harvard Newsletter: Triggering cell death in metastatic melanoma may pave the way for new cancer treatments
- New Molecular Metabolism study from the Biddinger Lab finds diabetes gene TCF7L2 is crucial for hepatic zonation and glutamine metabolism. Liver-specific Tcf7l2 knockout mice exhibit metabolic reprogramming, and decreased glutamine in humans with the rs7903146 variant. #BiddingerLab hsph.me/Tcf7l2
- Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out rdcu.be/eBbqV
- Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.
- Reposted by Harvard Molecular Metabolism🚨The final programme for #FusionAging25 is now live ⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days! 🗓️Final Poster & Reg Deadline: 07 Aug 2025 🔗 bit.ly/3FR0Z3E #FusionAgingResearch
- Reposted by Harvard Molecular MetabolismJust two of thousands of such stories. substack.com/home/post/p-...
- New study in @cp-devcell.bsky.social from the @bdmanning.bsky.social Lab. @yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...
- Using a phospho-mutant TSC2-5A mouse, the work reveals tissue-specific roles for this pathway in organ growth, including reduced brain and muscle size. Congratulations to all contributing researchers on this important publication! #Metabolism #ManningLab
- For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
- From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more: hsph.me/mitoT2D
- Reposted by Harvard Molecular Metabolism🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health. He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
- Reposted by Harvard Molecular MetabolismA reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
