Craig M. Crews
- Reposted by Craig M. CrewsToo much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...
- Reposted by Craig M. CrewsICYMI: New online! Long non-coding RNAs as orchestrators of dosage compensation
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- Reposted by Craig M. CrewsCheck out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
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- Reposted by Craig M. CrewsA reminder that proteins are highly dynamic molecules. 🟧 We have made much progress in measuring & predicting static protein structures, but the dynamics that animate life remain challenging to measure & model.
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- Reposted by Craig M. CrewsFoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
- Reposted by Craig M. CrewsOur paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:
- After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇
- Reposted by Craig M. CrewsA new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
- Reposted by Craig M. CrewsCongratulations to Scripps Research chemist Benjamin Cravatt on receiving the 2026 NAS Award in Chemical Sciences from the National Academy of Sciences (@nasonline.org) for providing foundational insights into enzyme function and dysregulation in disease!
- Reposted by Craig M. CrewsIf you are looking for a distraction, this seems cool. Sticky ends++. If it works as advertised, seems like it could be a game-changer. www.nature.com/articles/s41...
- Reposted by Craig M. CrewsOur paper on the structural and functional basis of the human dimeric OS9–SEL1L–HRD1 ERAD complex, together with @qilabuva.bsky.social, is now out! Huge congratulations to Leo, Emir, and Elina! www.nature.com/articles/s41...
- Reposted by Craig M. Crews“Sustained, strong science, as with all public goods, requires government investment if it is to deliver long-term societal benefit.” donmoynihan.substack.com/p/american-b...
- Reposted by Craig M. CrewsCheck this out TuroID attached to inactive Cas to identify transcription regulators 👇 www.nature.com/articles/s41...
- Reposted by Craig M. CrewsBiochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
- Reposted by Craig M. CrewsFYI: New online! Proteoform medicine: characterizing and targeting protein forms in human disease
- Reposted by Craig M. CrewsThe needle in the haystack problem: spotting novel drug targets among redundant evidence. Our solution? A time-series novelty metric for Open Targets Platform associations. Thanks to Coté Falaguera & @opentargets.org partners for making this happen.
- Out now in Nature Communications! 🧬🖥️ An Open Targets team developed a metric for the novelty of a target in the context of a disease, according to current available knowledge. This allows drug discovery scientists to easily identify potentially novel targets www.nature.com/articles/s41...
- Reposted by Craig M. CrewsComplexity at the ribosomal polypeptide tunnel exit. The major N-terminal acetyltransferase NatA may form different complexes on the ribosome to facilitate protein maturation. By Marius Klein & Klemens Wild in Irmgard Sinning's lab BZH & Nina McTiernan in my lab. www.nature.com/articles/s41...
- Reposted by Craig M. CrewsMYRF-1/LIN-42 timing complex controls temporal patterning! www.biorxiv.org/content/10.6...
- Reposted by Craig M. Crews📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026! 📅 8 - 11th September 2026 📍 EMBL Heidelberg, Germany 🔗 www.embl.org/about/i... Submit your abstract by 2nd June 2026 to a part of the event! EMBO #ChemicalBiology
- Reposted by Craig M. CrewsWhy can axolotls regrow limbs, but humans can’t? New work shows regeneration depends on cells from all sides of the limb coordinating their positional memories. 🔗 buff.ly/IPRgJYI
- Reposted by Craig M. CrewsEnzyme catalyzed bioorthogonal chemistry published at ACS Cent Sci pubs.acs.org/doi/10.1021/...
- Reposted by Craig M. CrewsPlenty on Prof. Dr. Werner Kirsten who discovered KRAS though: link.springer.com/article/10.1...
- Reposted by Craig M. CrewsPour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
- Reposted by Craig M. CrewsOur research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...
- Reposted by Craig M. CrewsNew preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
- Reposted by Craig M. CrewsI’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
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- Reposted by Craig M. CrewsHave a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.
- 🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made. Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: nature.com/articles/s41467-025…
- Reposted by Craig M. Crews0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...
- Reposted by Craig M. CrewsIn a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. scim.ag/45FfSj2
- Reposted by Craig M. Crews🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/QxyMbME Have a paper people should see? See what our Editors look for: buff.ly/tzg18vc
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- Reposted by Craig M. Crews'This video is the culmination of several yrs attempting to: (1) Figure out best practices for modeling ptn-ptn interactions; (2) Understand the outputs of programs like AlphaFold & adjacent software including quantitative metrics;(3) Communicate my thoughts to unwitting victims through workshops'
- Reposted by Craig M. CrewsThe presence of AU-rich elements (AREs) and Pumilio2 binding sites is a stronger predictor of half-lives.
- Reposted by Craig M. CrewsAn elegant approach for quantifying histone PTMs in single cells. It achieves scalability by combining multiplexing and parallelization. I am glad to see creative extensions of nPOP, just as @andrewleduc.bsky.social and I hoped would be enabled by its flexible design. 1/2
- Reposted by Craig M. CrewsSo cool - someone finally hacked 'the vault'. www.science.org/doi/10.1126/...
- Reposted by Craig M. CrewsWith so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...
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- Reposted by Craig M. CrewsDiscovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis @naturemedicine.bsky.social www.nature.com/articles/s41...
- Reposted by Craig M. Crews📝 Online now - the Review "Chemical biology approaches for protein tagging in mammalian cells" from Kaitlyn Toy, Jenna Beyer, and @gburslem.bsky.social. #SelfLabelingProteinTags #GeneticCodeExpansion #ncAAs #SplitInteins #SpatiotemporalControl Read it here 👉 authors.elsevier.com/a/1mRdq3S6Gf...
- Reposted by Craig M. CrewsOpenBind is a new open science effort to dramatically increase the number of protein:ligand structures in the PDB, pairing this with high-quality affinity data to enable a new generation of predictive structure and affinity models for drug discovery. Check it out: openbind.ai
- Join our mailing list for early access to AI-driven drug discovery insights & breakthroughs through the #OpenBind initiative. loom.ly/Vro7Lo8
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- Reposted by Craig M. CrewsTruly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis! Our @natcellbio.nature.com N&V: rdcu.be/eR25t Associated article: tinyurl.com/msf9x8fn
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- Reposted by Craig M. CrewsWe introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗 @ibc2-gu.bsky.social @goetheuni.bsky.social
- ProxiCapture Reveals Context-Dependent CRBN Interactore Landscape of Molecular Glue Degraders biorxiv.org/content/10.64898/20…
- Reposted by Craig M. Crews⌛ Increases in human life expectancy are not matched by increased health in old age. In a new review in FEBS Letters, @jetteleng.bsky.social et al. explore research on #hematopoieticstemcell rejuvenation in #ageing. ➡️ doi.org/10.1002/1873-3468.70215
