Thomas Arnesen
Prof. Univ. of Bergen & Helse Bergen | Basic & translational science | Molecular Biology | Cancer | Endocrinology | Rare diseases | Cytoskeleton | Ribosome | Protein biogenesis | PTMs | N-terminal acetylation
uib.no/en/rg/protein
- Reposted by Thomas ArnesenProtein degradation in Turnip - an adapted Arg/N-degron pathway. Preprint from Brian Mooney et al. Emmanuelle Graciet lab. www.biorxiv.org/content/10.6...
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- Complexity at the ribosomal polypeptide tunnel exit. The major N-terminal acetyltransferase NatA may form different complexes on the ribosome to facilitate protein maturation. By Marius Klein & Klemens Wild in Irmgard Sinning's lab BZH & Nina McTiernan in my lab. www.nature.com/articles/s41...
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- Reposted by Thomas Arnesen🎉 As we celebrate #TIBS50, we're highlighting #CitedClassics and revisiting the top cited article from each of the last 50 years! Check out this one from 1976! Read it here 👉 lnkd.in/egdN-AXt
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- Intricate regulation of Src kinases via N-terminal modifications and specific degradation pathways. A novel degradation pathway involving the CUL4A-DDB1-DCAF10 E3 ligase found by Kremer et al. Tanja Bange lab @andrea-musacchio.bsky.social @ispt-proteinterm.bsky.social www.nature.com/articles/s41...
- Reposted by Thomas ArnesenLast X-Mas, the ribosome gave you methionine, but the very next day, MetAP took it away. This year, to save histones from tears, NatD gives you an acetyl group. ⭐️ Explore our latest paper with the Deuerling lab @uni-konstanz.de and Shu-ou Chan lab @caltech.edu! www.science.org/doi/10.1126/...
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- Reposted by Thomas Arnesen📢 Our December issue is now online! Access the full issue 👉 www.cell.com/trends/bioch... 🎨 The cover brings warm, summertime vibes ☀️ and highlights a Feature Review on #AromaticAminoAcid biosynthesis in 🌱 from Jorge El-Azaz and @hiroshi-maeda.bsky.social. Cover art credit to Tae Park. (1/n)
- Reposted by Thomas ArnesenWe’ve made some new tools to manipulate N-recognins. Check them out in our preprint. www.biorxiv.org/content/10.1...
- Reposted by Thomas ArnesenJust registered for FEBS advanced workshop Protein termini 2026 in Palermo #proteintermini2026 (?) Looking forward to a great meeting. @ispt-proteinterm.bsky.social www.conferencecentral.org/webpage/view...
- Reposted by Thomas ArnesenOur study led by the extraordinary multitasking Daai Zhang shows here (tinyurl.com/3uhbkh54) that an additional O2 sensing mechanism based on histone methylation helps roots to prepare for potentially lethal hypoxic stress (such as in waterlogging)
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- Reposted by Thomas ArnesenSee you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
- Reposted by Thomas ArnesenWe are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details! Lab website: sites.google.com/site/danielg...
- Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
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- A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...
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- Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
- Reposted by Thomas ArnesenAre you excited?? Because I am! 25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐 Safe to say I'm fairly familiar with it now 🤭 Enjoy our issue!!!!!!!!!!!
- Hello Bluesky! We're celebrating ✨25th years of NRMCB✨ with our October Issue - out now! It offers a glimpse into our journal's scope - cell death, enhancers, cell cycle, migration, transposable elements, membrane contact sites & AI! go.nature.com/4nJUz6w
- Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
- Anatomy and habitat shape the oxygen sensing machinery of flowering plants | new preprint from Licausi lab @syno2xis.bsky.social #hypoxia #N-degron @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Thomas ArnesenNew review on the generation and consequences of N-terminal proteoform diversity from Evan Morrison and Olivia Rissland | #N-degron #RNA @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Thomas Arnesen🎉 As we prep for #TIBSCelebrates50, I'd love for participation from YOU! Share your creativity and have your artwork featured on the cover of @cp-trendsbiochem.bsky.social! 📆 Deadline is Sept 30!!
- 🚨 The #TIBSCelebrates50 call for cover art is open thru Sept 30 - share your ideas now! 🎨 Have your original artwork featured on the cover of the January issue! One design will be selected to celebrate this milestone with us. More info here 👉 www.cell.com/trends/bioch... #TIBS50 #CoverArt
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- Reposted by Thomas ArnesenGlad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
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- Reposted by Thomas ArnesenEmmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science! Give him a warm welcome 🎉 link: www.cell.com/cell/fulltex...
- Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...
- Disease resistance in rice steered by a long non-coding RNA via protein N-terminal acetylation | @ispt-proteinterm.bsky.social advanced.onlinelibrary.wiley.com/doi/10.1002/...
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- Global profiling of N-terminal cysteine–dependent degradation mechanisms | PNAS | @ispt-proteinterm.bsky.social www.pnas.org/doi/10.1073/...
- Reposted by Thomas ArnesenRepost appreciated: Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics. Deadline 7 September. More info: www.carlsonlab.se/join/
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- Mechanism for voltage-gated channel inactivation uncovered | N-terminal acetylation of the intracellular domain of the Shaker potassium channel is key for plugging the pore | By Kenton Swartz lab in @nature.com @ispt-proteinterm.bsky.social www.nature.com/articles/s41...
- How to define degrons and E3 ligase specificities by peptide pulldowns | Methods in Enzymology | Kwon and Ji labs | #KCMF1 #Cysteine #Arg/N-degron @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- Using a specific antibody to detect proteins carrying N-terminal formylation | Methods in Enzymology | Hwang lab @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- Assessing protein N-terminal myristoylation. Detailed protocols by Ed Tate's group in Methods in Enzymology. #lipidation @ispt-proteinterm.bsky.social @imperialcollegeldn.bsky.social www.sciencedirect.com/science/arti...
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- Expression and purification of ribosome associated factors: Methionine aminopeptidases and N-terminal acetyltransferases | Methods in Enzymology | Marius Klein and Irmgard Sinning @uniheidelberg.bsky.social @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- How to express, purify and assess the activity of the ATE1 arginyltransferase | Methods in Enzymology | Yi Zhang lab @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- Method to determine the identity and modification state of plastid precursor protein N-termini in the cytosol by combining protoplast protein import assays with targeted mass spectrometry | Methods in Enzymology | Baginsky lab. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
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- Gid11 is a substrate receptor of the GID multisubunit E3 ligase during a metabolic switch. Specific degradation of proteins linked to glycolysis via their N-terminal threonine lacking N-terminal acetylation. #N-degron Khmelinskii lab @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
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- DEGRONOPEDIA - a web server for identifying and predicting protein degradation signals across eukaryotic proteomes. Detailed guide by Natalia Szulc @lumirare.com and Wojciech Pokrzywa @wpokrzywa.bsky.social in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- How to use bacteria for arginylation assessment. Co-expression of ATE1 and substrate outlined by Yi Zhang and colleagues in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- How to detect protein N-terminal arginylation - a key step of protein degradation via the Arg/N-degron pathway. By Jasper Eising and @ndissmeyer.bsky.social in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- How to assess protein stability and N-degrons via the Ubiquitin reference technique. From the Protein Metabolism Lab (Yong Tae Kwon) at SNU Seoul ups.snu.ac.kr in Methods in Enzymology @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Thomas Arnesen📣 Our July issue is live! Inside, you'll find a variety of articles focused on #mitochondrialbiochemistry, plus an interview with many of the authors! The cover (by @brischigliaro.bsky.social) emphasizes one of these reviews from Antoni Barrientos et al. Find it here 👉 www.cell.com/biochemical-...
- Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...
- Reposted by Thomas ArnesenCelebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis
- A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells: Cell Chemical Biology www.cell.com/cell-chemica...
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- Reposted by Thomas ArnesenVery excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...
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- Reposted by Thomas ArnesenHow did oxygen-sensing evolve in plants? In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk “ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia” www.cell.com/molecular-pl...
- Reposted by Thomas ArnesenWe are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
