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HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Huntingtin-interacting protein K (HYPK) promotes the activity of N-terminal acetyltransferase A (NatA), which cotranslationally acetylates 40% of the eukaryotic proteome. Kinetic and in-cell measurements revealed that HYPK acts as a ribosome exchange factor for NatA, enabling its access to and acetylation of the translatome.
