Clausen Lab
Molecular machines, Proteostasis, Ubiquitin Signaling, Cell Autonomous Defense, Protein Disorders and Team Nematode
@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
- Reposted by Clausen LabToo much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...
- Reposted by Clausen LabA new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...
- Reposted by Clausen LabI’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...
- Reposted by Clausen LabNature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling go.nature.com/4klvMp1
- Reposted by Clausen LabOur latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells. www.cell.com/molecular-ce...
- Reposted by Clausen LabHave a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.
- 🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made. Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: nature.com/articles/s41467-025…
- Reposted by Clausen LabNew preprint! Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability. We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
- Mapping the GCK-GKRP interaction landscape using deep mutational scanning by reverse two-hybrid screening biorxiv.org/content/10.64898/20…
- Reposted by Clausen LabWith so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...
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"RNAPII clusters reflect local accumulations of transcriptionally engaged polymerases and do not form through higher-order mechanisms such as phase separation" 😬 www.biorxiv.org/content/10.1... by the @mirlab.bsky.social - Reposted by Clausen LabHey #portfolioday! I'm a bloke who used to investigate Genetics before turning into a full-time Artist. Now I do handmade installations, molecular graffiti, and digital design to convey the beauty of Science.
- a Trp/Phospho/Ub trifecta linking metabolism and degradation - wow 🤩 big congrats to the whole team for this amazing, almost historic study.
- New year, new preprint! 🎊 We are excited to share our recent work on #E3 ligase regulation in #metabolism! www.biorxiv.org/content/10.6... #ubiquitin #targetedproteindegradation #chemicalbiology 1/6
- Reposted by Clausen LabJoin us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026
- Reposted by Clausen LabCan we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
- Reposted by Clausen LabWe are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
- Reposted by Clausen LabThis is really cool and important.
- Some of the longest-lived organisms on Earth aren’t whales, trees or corals, but microbes buried deep in the earth. This eye-opening essay examines the slowest lives on Earth, asking what such lives mean for how we define life itself @karenlloyd.bsky.social
- Reposted by Clausen LabWriting is thinking - a short but memorable thread.
- Reposted by Clausen LabThe Clavel Group is recruiting a new postdoc for two possible projects dealing with plant-virus interactions and selective autophagy! More (wordy) details below ⬇️🌱🦠
- Reposted by Clausen LabVaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
- Reposted by Clausen LabNew work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...
- Reposted by Clausen LabExcited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
- Reposted by Clausen LabFür seinen Beitrag zum Verständnis der zellulären Kraftwerke (Mitochondrien) wurde Nikolaus Pfanner in die Accademia Nazionale dei Lincei, die nationale Akademie der Wissenschaften Italiens, aufgenommen. Zudem erhielt er die Walter Neupert-Medaille. ufr.link/auszeichnung-pfanner @cibss.bsky.social
- Reposted by Clausen LabThe silence from the pro-LLPS crowd is deafening. As a (truly) unbiased observer, I for one am very curious to see the counterarguments, which surely must exist. The skeptics are having their day.
- Reposted by Clausen LabThis has now been published in print! Check it out: www.science.org/doi/10.1126/...
- Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...
- Reposted by Clausen LabJoin @uofglasgow.bsky.social for a funded 3.5 year PhD programme: www.gla.ac.uk/colleges/mvl... Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.
- Reposted by Clausen Lab🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
- Reposted by Clausen LabAre you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
- Reposted by Clausen Lab[This post could not be retrieved]
- Reposted by Clausen LabInferring LLPS from macroscopic properties (roundness, “liquidity”) is unhelpful. Subcellular compartments likely arise from specific interactions among multivalent proteins—robust and insensitive to environment. These interactions can generate structures with some LLPS-like properties
- great post on LLPS, flying elephants and phase behaviour beyond thermodynamics #PhaseFiction
- The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It… 1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
- Reposted by Clausen LabThe devil is in the details Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41... success rates against each target range from 0% to 2% 😆 for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
- Reposted by Clausen Lab✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
- Reposted by Clausen LabJoin us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.” We look forward to seeing you there!
- Reposted by Clausen LabRegistration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social www.embl.org/about/info/c...
- Reposted by Clausen Lab🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...
- Reposted by Clausen LabVery glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
- Reposted by Clausen LabPostdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
- Reposted by Clausen Lab📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
- Reposted by Clausen Lab'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
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- Reposted by Clausen LabOn that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.
- Reposted by Clausen LabJust out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
- Reposted by Clausen LabThe proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert) Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation doi.org/10.1101/2025...
- The importance of UBQLN2 ubiquitylation for its turnover and localization biorxiv.org/content/10.1101/202…
- Reposted by Clausen LabScience has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John www.cam.ac.uk/research/new...
- Reposted by Clausen LabAllosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides Axel Mogk, Marta Carroni et al www.embopress.org/doi/full/10....
- Reposted by Clausen LabAllosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...
- Reposted by Clausen LabSpectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now
- Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
- so well deserved
- Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
- Reposted by Clausen LabDear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...
- Reposted by Clausen LabThe Vienna BioCenter PhD program in Molecular BioSciences will offer 20+ fully-funded positions in the Autumn Call which is now open. Please share. Further details: www.vbcphd.at
- Reposted by Clausen LabOur Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu... With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets: Wadjet—Keeping a watchful eye on circular DNA. www.cell.com/structure/fu...
- Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.
- Reposted by Clausen LabWARM congratulations to: Tom DENDOOVEN, @martinpacesa.bsky.social, @mschuhmacher.bsky.social , @lfmilles.bsky.social, @preinerin.bsky.social,Markus Hopfler, @charleneboumendil.bsky.social, Gergo Gogl, @shifralansky.bsky.social, @alexanderbelyy.bsky.social,Erik Benson, @dbojar.bsky.social! 🤩 #ERCStG
- 📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope
- Reposted by Clausen LabJob opportunity: come join the excellent and friendly #ProteostasisUK community!
- Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT
- Reposted by Clausen LabI’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!
- Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...
