dimitristypas
Senior editor @naturesmb.bsky.social. Views and opinions are personal.
- Reposted by dimitristypasNew online: Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription
- A striking mechanism in how histone supply is regulated out @natsmb.nature.com which is definitely worth reading, www.nature.com/articles/s41...
- Reposted by dimitristypasExciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...
- Reposted by dimitristypasHappy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
- I'd be remiss not to highlight this study www.nature.com/articles/s41... from the lab of @kevincorbett.bsky.social now out @natsmb.nature.com Always striking to see how inventive bacteria are and what an unorthodox ubiquitylation-like mechanism this may be (probably oxyester dependent).
- Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
- Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...
- The @natsmb.nature.com Returning Home series is now complete, www.nature.com/nsmb/article... with the final piece by Hugo Sepulveda on his return to Chile published. It has been a joy to work on this series and, if our readers appreciate these pieces, I hope that it may continue or evolve!
- We @natsmb.nature.com aim to provide a stage for our readers. That includes voicing their experiences and perspectives. We hope this makes us a more attuned and representative outlet for our communities. We launched new content to do so and explain why in our editorial www.nature.com/articles/s41...
- Reposted by dimitristypashere is the correct link: ista.ac.at/en/job/tenur...
- Reposted by dimitristypasCome work with us! 🧪
- Reposted by dimitristypasNew online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
- Our series on scientists Returning Home after working abroad continues here @natsmb.nature.com Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...
- Reposted by dimitristypasNew online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
- The September @natsmb.nature.com issue is out! www.nature.com/articles/s41... We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
- Reposted by dimitristypasNew Online! Learning about break-induced replication from bacteriophages
- A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @natsmb.nature.com www.nature.com/articles/s41...
- Reposted by dimitristypasWe have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
- Reposted by dimitristypasThree-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: marie-helene.verlhac@college-de-france.fr
- This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...
- Reposted by dimitristypasCongratulations to Masahiro Nagano on his new paper on STAG3-cohesin. STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation. www.nature.com/articles/s41...
- @natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...
- Reposted by dimitristypas📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...
- Reposted by dimitristypasAnother installment of the 'Returning home" series at NSMB. This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw
- Out @natsmb.nature.com a great Q&A with @fmattiroli.bsky.social. I really enjoyed reading it and I am very happy that Francesca had the time to work with us. www.nature.com/articles/s41...
- Did not have time to post about this before vacation. Such a joy to have this chat with @davidlabmsk.bsky.social and Nobel Laureate Charles Rice on Yael's amazing work, capitalising on chromatin biology to understand hepatitis. www.nature.com/articles/s41...
- Reposted by dimitristypasWorking with collaborators at the Crick Institute and the University of Utah, CSHL's President and CEO Bruce Stillman explores how pre-replicative complexes (pre-RCs)—even earlier than ORCs—assemble to initiate DNA replication in all plants, animals, and fungi.
- Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...
- Reposted by dimitristypasCheck out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
- Out @natsmb.nature.com a Review on origin licensing with probably the most comprehensive (and coolest!) movies on how pre-RC assembly works. Decades of structural and biochemical work are beautifully illustrated. Kudos to Janet Iwasa, John Diffley and Bruce Stillman. www.nature.com/articles/s41...
- @natsmb.nature.com recently published a very interesting pair of insightful studies on the role of H2A.Z during oocyte maturation by the labs of Wei Xie, Yu Zhang, and Yunlong Xiang, nature.com/articles/s41..., and the lab of Azusa Inoue, www.nature.com/articles/s41....
- This editorial details why we think it's a good idea to standarise reporting of microscopy data and what we are doing towards that. I also feel that it is both important and a step towards helping the community. www.nature.com/articles/s41...
- Reposted by dimitristypasThis is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u A short thread follows 1/n
- Reposted by dimitristypasIf heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments www.biorxiv.org/content/10.1...
- Reposted by dimitristypasGo fund a brain gain The gutting of US research funding represents a once-in-a-generation opportunity for Europe to boost world-class research deprioritized by the Trump administration go.nature.com/4jGhU6V
- Reposted by dimitristypasCome and work with our new colleague on very cool project!
- So excited to share that we @natsmb.nature.com are hiring a new editor! If you are interested about working with an intelligent, compassionate and funny team helping scientists publish great research, please consider applying. Deadline June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...
- Reposted by dimitristypasHow to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...
- Dr. Basto recaps and discusses in this N&Vs www.nature.com/articles/s41... two very interesting TRIM37-mTOCs papers recently out @natsmb.nature.com, by the labs of Prof. Holland www.nature.com/articles/s41... and Prof. Oegema and Desai www.nature.com/articles/s41...
- Branched ubiquitin chains are both very interesting and somewhat lagging behind in how well we understand them. Insightful work by @samuelmaiwald.bsky.social from the lab of Brenda Schulman now out @nature.smb@nature.com delineating a key player, TRIP12. www.nature.com/articles/s41...
- @natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!
- For the DNA polymerase θ afficionados: www.nature.com/articles/s41... This N&Vs by Sylvie Doublié nicely contextualises the progress imparted by this NSMB paper www.nature.com/articles/s41... by @landerlab.bsky.social and this NatComms paper www.nature.com/articles/s41... by the Chen/Pomerantz labs
- Reposted by dimitristypasOn 9 May 2025, we launched the Artificial Intelligence Methodology in Structural Biology Collection between: Communications Biology, Nature Communications, Nature Structural & Molecular Biology, and Scientific Reports. www.nature.com/collections/... We are looking forward to your submissions!
- Reposted by dimitristypasNSMB is also part of the DNA repair and human disease collection, with Communications Biology, Nature Chemical Biology, Nature Communications, and Scientific Reports. www.nature.com/collections/... NSMB has been a welcoming venue for insightful genome stability studies, hoping to continue to do so.
- Reposted by dimitristypasSuper happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!
- Out today and I feel that I have to explicitly mention this very interesting story by the lab @maltegersch.bsky.social, developing specific inhibitors for the key mitophagy regulator USP30, based on a potential unifying and exploitable facet of USPs. www.nature.com/articles/s41...
- Reposted by dimitristypasI am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
- Many interesting articles recently out @natsmb.nature.com. Here two that piqued my interest: www.nature.com/articles/s41..., another example of insightful work on the mechanisms of early development, www.nature.com/articles/s41..., another example of genomics technique development with XCI insight
- Reposted by dimitristypasCup? Platter? Stained glass? Our imaginations were inspired (even during uncertain times!) by these beautiful molecular complexes: the Erlin and prohibitin complexes implicated in quality control at the ER and mitochondria, respectively. Check them out here: www.biorxiv.org/content/10.1...
- Finally for today, a collaborative effort led by the lab of @zeqiraj.bsky.social discovers molecular glues for BRISC, a deubiquitylating enzyme regulating inflammatory signalling. A delightful read here: www.nature.com/articles/s41... and the authors original thread here: bsky.app/profile/zeqi...
- Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social @antoncalabrese.bsky.social @bioscienceleeds.bsky.social
- Another insightful piece recently out @natsmb.nature.com delineating how Shigella utilises its effector IpaH1.4 to counteract host RNF213-induced LPS ubiquitylation. Very interesting work by the lab of @felixrandow.bsky.social. If you want to, have a go at it: www.nature.com/articles/s41...
- We @natsmb.nature.com recently published an insightful manuscript on ubiquitin-independent proteasomal degradation via the NUB1-FAT10 axis by the lab of Andreas Martin. A very interesting read found here: www.nature.com/articles/s41...
- I am bit late to write about this perspective but I thought I would be remiss not to mention it. In this manuscript, the authors contextualise the importance of accurately intepreting dual-reporter results and propose minimal guidelines to ensure such accuracy.
