Martin Loose
Interested in protein self-organization. We rebuild the bacterial cell division machinery and small GTPase networks in vitro. https://looselab.ist.ac.at
- Reposted by Martin LooseExcited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
- Time to say goodbye 👋 After finishing his paper and defending his thesis, Marko is starting a new chapter as a postdoc at @cemess.bsky.social (Uni Wien). We’ll miss having you around! Congrats and all the best!
- Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings! Preprint: www.biorxiv.org/content/10.1...
- Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings! Preprint: www.biorxiv.org/content/10.1...
- We examined ~4,600 FtsZ sequences and found that charge segregation in the disordered CTL appears to correlate with cell width across species: FtsZ from wider bacteria tends to have more uniform charge distribution in the linker, whereas high charge segregation is mostly found in skinny cells.
- In vitro, increasing the charge segregation in the linker increased filament curvature and decreased Z-ring size! Treadmilling dynamics were unaffected.
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View full threadFeedback and comments are very welcome!
- Reposted by Martin LooseOur fully-funded PhD program is open for applications! Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity. Apply now: phd.ista.ac.at
- The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)! More info here: apply.ista.ac.at/comp_structu...
- here is the correct link: ista.ac.at/en/job/tenur...
- Reposted by Martin LooseThrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....
- We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...
- *salary is € 1,523* gross/month!
- Reposted by Martin LooseWe're hiring a postdoc! Join our ActinID project to explore an uncharacterized actin-binding protein. - Background in cell and/or structural biology? - Eager to bridge both fields? Get in touch if you're curious or have questions! #cellbiology #cryoEM #cryoET #actin ista.ac.at/en/job/postd...
- One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...
- This project was initiated and led by fantastic postdoc Benjamin Springstein, @huepfkiesel.bsky.social in a collaboration with the labs of Florian Schur (cryo-EM) @schurlab.bsky.social at @istaresearch.bsky.social and Daniela Megrian (phylogenetics) from @ipmontevideo.bsky.social
- By combining structural, evolutionary, in vitro reconstitution and cell biology approaches we uncovered a new cytoskeletal system - called CorMR - that evolved from a ParMR system.
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View full threadWe’re excited to share this story and would love your feedback!
- Looking for a student or postdoc! Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy? Help us uncover new protein-protein interactions — from in silico to in vitro. Join us at @istaresearch.bsky.social 👉 looselab.org 🧬💡🔬🎡
- Very cool findings from Paula, Andrea et al.! Excited that my student Roman could contribute! See Andrea’s thread below for more details:
- It has been coming a long way... happy to share our latest work with you: www.biorxiv.org/content/10.1... Here, we show the importance of septal fortification by the Class A Penicillin Binding Protein, PBP1b, in E. coli and provide a molecular mechanism for this function. (1/12).
- Reposted by Martin Loose
- Reposted by Martin Loosewho doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021 Movie S2 from journals.plos.org/plospathogen... #MicroSky
