Jerelle Joseph
Assistant Professor, Princeton University | biomolecular condensates + computer simulations | https://josephgroup.princeton.edu (she/her)
- How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
- I am very excited to share our pre-print that was just released on the bioRxiv entitled "Biomolecular Condensates Dictate the Folding Landscape of Proteins" doi.org/10.64898/202... Very grateful for @jerelleaj.bsky.social and the members of the Joseph Group for their support on this project! (1/4)
- Out on the #bioRxiv in collaboration with @luciastrader.bsky.social, we probe the molecular basis for thermoresponsive condensation in plants! Work led by Sunita Pathak and @ananyac2000.bsky.social 🥳🥳 www.biorxiv.org/content/10.6...
- Our "Roadmap for Condensates in Cell Biology" is now available on arXiv: arxiv.org/abs/2601.03677 🎉 This article summarizes the interdisciplinary weekly discussions we had at our condensate workshop at KITP in the summer of 2025. Feedback is very welcome!
- Want to learn about how we use computational approaches at different scales to study biomolecular condensates? Check out our latest review, out in Advances in Physics X @juliamaristany.bsky.social @alinaemelianova.bsky.social @rcollepardo.bsky.social www.tandfonline.com/doi/epdf/10....
- Gave my last lecture yesterday. Started celebrating that, for the first time, I managed an entire semester without getting sick. Started feeling sick today 🤒…had a solid run though 😅
- On the cover of #SoftMatter! Our work on condensate microstructure. Cover designed by Daniel Tan☺️ pubs.rsc.org/en/content/a...
- Have not fully stopped but definitely way less now than before 💔
- Reposted by Jerelle JosephVery insightful reconsideration what Stress Granules might actually be good for! Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work. Amazing talk & scholarship by @drummondlab.bsky.social! youtu.be/caAPToh8v0Q
- Is there a way to directly connect microstructural dynamics of condensates to their mechanical response? In his new pre-print, Pablo presents a “condensate Deborah number” that does just that! www.biorxiv.org/content/10.1...
- Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!! Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!! pubs.acs.org/doi/10.1021/...
- Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia! pubs.rsc.org/en/content/a...
- Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
- New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽 www.biorxiv.org/content/10.1...
- @ananyac2000.bsky.social (not sure why your tag got messed up, my bad)! 🥳🥳
- Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester
- On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/
- By simulating ~65 atomistic system’s this work probes the partitioning landscape of four model condensates (varying in their hydrophobic residue content). We find that BOTH characteristics of condensates and small molecules dictate partitioning 2/
- We also find that condensates enriched in hydrophobic residues exhibit stronger selectivity for small molecules. However those rich in polar residues can be selective for higher log P compounds that also have high dipole moments! 3/
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View full threadOur new approach, MAPPS, opens up new opportunities for screening small-molecule-condensate interactions on computers! Read the article here: pubs.acs.org/doi/full/10.10… 6/6
- I second that!!! ♥️
- So grateful to my co-coordinators, @zwickergroup.bsky.social, @jerelleaj.bsky.social, and Frank Jülicher, to all of the participants for sharing their knowledge and contributing to such open and stimulating discussions, and to everyone @kitp-ucsb.bsky.social for making our stay so comfortable. 🙏🙏🙏
- Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
- Reposted by Jerelle Joseph[Not loaded yet]
- Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!
- 📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
- “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions! www.kitp.ucsb.edu/activities/b...
- There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰
- @jerelleaj.bsky.social, master painter 👩🏽🎨 of the blackboard 👩🏽🏫, in action! 🤩 She is amazing at capturing the essence of our complex, meandering (and sometimes contentious) discussions @kitp-ucsb.bsky.social
- This was a big week for the group! Our four seniors graduated and made us very proud. Ethan graduates as a Sachs Scholar, Ian secured several minors, Daniel won the MacCracken Senior Thesis Award from SEAS, and Caroline earned the highest awards in both CBE and Engineering!
- I’m beyond proud of them! And so thankful for the graduate students and postdocs in the group who served as their day-to-day mentors! Looking forward to all they accomplish in the next chapter of their careers! ♥️♥️
- Reposted by Jerelle Joseph@natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!
- See u all in Santa Barbara!!
- It's finally here! After almost 3 years of planning, I'm thrilled to discover the literal and figurative blue skies @kitp-ucsb.bsky.social @jerelleaj.bsky.social, @zwickergroup.bsky.social, Frank Jülicher and I will kick off our program on biomolecular condensates next week!
- Thanks to @natsmb.nature.com for interviewing on our work: “seeing biomolecular condensates with computation” www.nature.com/articles/s41...
- Yesterday was a great day to be at WashU!
- Join our interdisciplinary team developing computational approaches to understand and engineer biomolecular condensates. We’re looking for a postdoc—please apply or share with interested persons! 👩🏽💻💧🧬 puwebp.princeton.edu/AcadHire/app...
- Congratulations to our 4 seniors (Dan, Ethan, Caroline and Ian) on defending their theses today in the #CBE poster session!! We’re so proud! They’re heading off to Rockefeller, Caltech, Fancy Industry job, and UCLA in the fall! 3/4 were the first 3 juniors in the group. *Cue the tears*😭😭
- 📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
- Had the best time at Duke over the last three days! Many many thanks to @gladfelterlab.bsky.social and the entire Center for Quantitative Living Systems for being such amazing hosts!
- The “social” network inside condensates is quite cliquey 🙃🙃 co-lead by undergrad student Daniel Tan w/ postdoc Dilimulati 🥳🥳🥳 Preprint out!! www.biorxiv.org/content/10.1...
- Congratulations to Daniel Tan from our group for winning the #BPS Poster Award Competition!! 🥳🥳🥳 What an achievement!!! Cheers to all the other winners!!
- What a week!
- This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
- Reposted by Jerelle JosephPredicting small molecule partitioning into biomolecular condensates is key for designing drugs that target aberrant condensates. But what drives partitioning at the molecular level? (1/6) 🧵👇
- Second new preprint ‼️ Work led by brilliant postdoc @alinaemelianova.bsky.social (in collab with Pablo Garcia and Daniel Tan) where we leverage multiscale simulations to predict small-molecule partitioning into condensates 💦💊🙌🏽 www.biorxiv.org/content/10.1...
- New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽 www.biorxiv.org/content/10.1...
- New pre- print alert‼️ Fantastic work led by Gable Wadsworth (experiments) and Dilimulati Aierken (simulation)! Excited to probe molecular grammars of nucleic acid LCST behaviors in collaboration with @priya-r-banerjee.bsky.social 🥳🥳
- New preprint in collaboration with @jerelleaj.bsky.social!! We show that the 2’-OH group of ribose sugar plays a crucial role in RNA condensation, while its absence in DNA inhibits phase separation and percolation, a transition linked to condensate arrest. 1/2 www.biorxiv.org/content/10.1...
- Huge congrats to Ethan from our group on being named a Sachs Scholar!!! 🥳🥳🥳 www.princeton.edu/news/2025/02...
- Congratulations to Daniel Tan from our group for winning the #BPS Poster Award Competition!! 🥳🥳🥳 What an achievement!!! Cheers to all the other winners!!
