Jeremy Schmit
Statistical mechanics & biophysics theorist. Emergent properties in biomolecules. Systems biology curious. Father, former athlete. Kansas State University Physics. Occasional appearance of Legos.
- Reposted by Jeremy SchmitMultidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...
- Reposted by Jeremy SchmitPhysicist Leo Szilard, in a short science fiction story from 1948, describing how to retard science by making the funding application longer and harder than the proposed research - now called the ‘Szilard point’
- Reposted by Jeremy SchmitExcited to share the first paper from my group with Gianluca Teza (MPI-PKS) and Attilio L. Stella (U Padova)! “Coarse-Graining via Lumping: Exact Calculations and Fundamental Limitations” shows when lumping is exact and when it fails even without approximations. arxiv.org/pdf/2512.11974
- Finally!
- I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
- Very cool work. I also thought about Hwa's growth laws while reading the thread. Quantitative curves are great to stimulate chin scratching!
- 1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size! www.biorxiv.org/content/10.6...
- Reposted by Jeremy SchmitHere’s the thing, emerging scientists aren’t going to flee to do science elsewhere…they just won’t do the science. We will lose at least one, if not two generations of knowledge if we don’t get this shit sorted out immediately.
- Reposted by Jeremy SchmitThe US is funding fewer grants compared to the past. The money is given in one lump sum instead a yearly infusion from a multi-year funded grant. This leads to more competition, less $ and time to do research. Not a win-win situation. 🧪🎁🔗 www.nytimes.com/interactive/...
- Reposted by Jeremy Schmit"I, at any rate, am convinced that He is not playing at dice." Einstein sent a letter to Max Born #OTD in 1926, in which he gave his oft-quoted objection to the probabilistic interpretation of the wavefunction in quantum mechanics. 🧪 ⚛️ You may be surprised by where this is headed. (1/n)
- Reposted by Jeremy SchmitWe're back for our final seminar of 2025 with talks from @alexholehouse.bsky.social and Birthe Kragelund! 1 pm EST or 7 pm European time. If you're not already signed up, head on over to idpseminars.com to register!
- New publication! How to read the curves in biomolecular phase diagrams! A collaboration between the Schmit Group and Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social. 1/7 pubs.acs.org/doi/10.1021/...
- Multi-component condensation has a lot in common with salts, which have simple power-law phase boundaries. The exponent in the power law comes from the salt’s dissociation constant, the so-called “solubility product”. 2/7
- Biomolecular phase diagrams rarely show power law boundaries. We show that the solubility product power law still works, but it is hidden by two opposing effects. 3/7
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View full threadA lot of complexity comes from thinking in terms of two-phase dilute/dense equilibrium. A three-state monomer/oligomer/dense framework is much easier. The monomer/oligomer and monomer/dense equilibria are easy to understand (and calculate) and the oligomer/dense comes along for free. 7/7
- Reposted by Jeremy SchmitOut now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia! pubs.rsc.org/en/content/a...
- Reposted by Jeremy SchmitExcited to share our paper: “Historical and Experimental Evidence that Inherent Properties Are Overweighted in Early Scientific Explanation” I’m grateful to Zach Horne & my dear advisor @andreicimpian.bsky.social to let me be part of this project, it was a great experience! doi.org/10.1073/pnas...
- Reposted by Jeremy SchmitBiomolecular phase boundaries are described by a solubility product that accounts for variable stoichiometry and soluble oligomers biorxiv.org/content/10.1101/202…
- "What does this curved line mean?" Like palm reading for your phase boundary. Plus, when is your condensate actually an oligomer (or vice versa)? A new preprint from the Schmit Group, in collaboration with Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social www.biorxiv.org/content/10.1...
- Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
- Reposted by Jeremy SchmitWhat nanometer structure-function relationships exist in your favorite condensate? We hope you will try to measure it! Congrats to Kris, @evdokiiap.bsky.social, Abby, Archish, Gandhar, and @schmitbiophysics.bsky.social . 4/4
- Reposted by Jeremy SchmitIn lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
- Nanometer condensate organization in live cells derived from partitioning measurements biorxiv.org/content/10.1101/202…
- Reposted by Jeremy SchmitHere is a thread on a paper we published on Dec 30th: doi.org/10.1038/s414... In this collaborative work, we looked at the structure of proteins behind Huntington’s disease. HD is an inherited neurodegenerative disease, with patients having a mutated form of the huntingtin gene. (1/..)
- Hoping the demise of the clock app drives me to discover more cool science here.
- When the turkey is supposed to be the centerpiece but your 12yo steals your thunder.
- Reposted by Jeremy SchmitCutting NIH funding to improve federal cash flow is like cutting the wings off an airplane to make it lighter.
- Shopping for summer 2025 conferences. Pitch me your favorites in: Biological LLPS Amyloids Self-assembly Soft condensed matter Physics Chromatin Systems biology Other???
- Reposted by Jeremy Schmit
