Alex Holehouse
Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
holehouselab.com
- Reposted by Alex HolehouseIDPSeminas is back again TOMORROW! Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com. Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!
- Reposted by Alex HolehouseLast chance to submit your abstract for 'Cellular mechanisms driven by phase separation'! Let's tackle emerging questions in cellular organisation, adaptation, and robustness together 🧬🦠 #EESPhaseSeparation 19 – 22 May 2026 Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
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- “So is it cold in St. Louis during the winter, or does it stay pretty warm?” Yes.
- Reposted by Alex HolehouseI am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]
- WorkDay is the hardest, most complex puzzle game I've ever played. Graphics are terrible, gameplay is clunky, characters are numerous but never actually useful or interesting, but the difficulty is 11/10. Truly l33t.
- Reposted by Alex HolehouseThe @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for their research accomplishments. APPLY by sending your nomination packet to idpsubgroupbps@gmail.com by Dec 15th! Find all information at: www.biophysics.org/awards-fundi...
- Reposted by Alex HolehouseYou can do this right now: Think of a person who wrote a paper you love, whose work influenced or helped you, or has made your professional life better. Search up their email address. Shoot them a quick email of thanks. It means so, so much. This is a rough time of year, share some joy.
- Reposted by Alex HolehouseWe're back for our final seminar of 2025 with talks from @alexholehouse.bsky.social and Birthe Kragelund! 1 pm EST or 7 pm European time. If you're not already signed up, head on over to idpseminars.com to register!
- Love this; inspired by early experiences and cemented by the incomparable @jiwasa.bsky.social at an incredible workshop she and @theroglab.bsky.social organized in '22, I've become thoroughly convinced that - at least for me - developing figures from scratch is a key part of scientific inquiry.
- Brief interruption to science: For the four folks reading this who may be interested, death metal band Emperor is touring the US next spring. If you care, you care 🤘.
- Reposted by Alex HolehouseNew preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
- Reposted by Alex HolehouseHow to tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠 Bringing together scientists from diverse fields to foster new discoveries in condensate biology. Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl 📅 19 – 22 May 2026
- Reposted by Alex HolehouseThe First Annual Virtual WALII Symposium: Exploring Life Without Water is ONE WEEK AWAY! 🗓️💧 Register now to join us on November, 18! www.walii.science/virtual-symp...
- The fact that if you search for something on Google with a typo, it suggests a correct spelling (good!), and you select that spelling to search (also good!), but then click on the search bar, it RETAINS THE WRONG SPELLING is among the most bizarre UI/UX decisions I've seen in many years.
- Reposted by Alex HolehouseA university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
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- Reposted by Alex HolehouseHumbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
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- Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully. Will stay for the foreseeable future!
- Reposted by Alex HolehouseI'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se
- Last week, Washington University made the perhaps questionable decision to award me tenure.
- There are many people to thank, but firstly, the folks who got me here: @rohitpappu68.bsky.social for mentorship, advice, support, and freedom while I was a graduate student and postdoc in his lab, and for all the advice and support after I left.
- Reposted by Alex HolehouseJoin us for the first inaugural WALII Virtual Symposium on Tuesday, Nov 18, 2025! Abstract submissions for a contributed talk are NOW OPEN! Selected speakers will be chosen in Oct. & will present 10-12 min. talks followed by 3-5 min. of Q&A. Visit: walii.science/virtual-symp...
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- Reposted by Alex Holehouse1/14 Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵 Free article: go.nature.com/4oRUC1q
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- Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out: eeik.fa.us2.oraclecloud.com/hcmUI/Candid... Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
- Reposted by Alex Holehouse🚨🚨IDPSeminars is BACK 🚨🚨 Season 19 (!) gets underway next week with @rohitpappu68.bsky.social and Meredith Jackrel! Date: Thur. Sept 4th Time: 1 pm EST [USA] / 7 pm CET [Europe] If you've previously signed up, you should be good to go, otherwise, please sign up at idpseminars.com
- Our 4th generation protocol book has arrived!!
