Hiten Madhani
Gene regulation in health and disease | Professor/Vice-Chair @UCSF Dept. of Biochemistry and Biophysic | via Stanford, UCSF and MIT | https://madhanilab.ucsf.edu
- Meanwhile in China…
- We're launching a research lab at SMART. Shenzhen Medical Academy for Research and Translation is a newly established institute with long-term funding mechanisms for internal and external investigators. At full capacity SMART aims to support up to 400 labs. www.scmp.com/news/china/s...
- Reposted by Hiten MadhaniBREAKING: Over 680 members of the National Academy of Sciences, Medicine, and Engineering have endorsed articles of impeachment against RFK Jr. (1/2 🧵)
- Reposted by Hiten MadhaniMy weekly update on NIH funding. This is for all projects. The breakdown for competing and non-competing awards will follow. 1/4
- Not good. I don’t understand why dems acquiesced on this.
- Reposted by Hiten MadhaniBhattacharya, a moment ago: "What you've been seeing in the press is that there have been funding cuts. There haven't been funding cuts. What there has been is a change in agency priorities." Our year in numbers begs to differ www.nature.com/immersive/d4...
- Reposted by Hiten MadhaniImportant update: a federal judge has ruled that Russ Vought & OMB were breaking the law & must tell the public exactly how they are spending (or not spending) funds appropriated by Congress. I wrote this law years ago to ensure transparency and accountability.
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- Reposted by Hiten Madhani🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved! 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- Reposted by Hiten MadhaniWe could have 4 JWST’s or a science mission at every planet. The NIH could be funded for two years. Or 1.5 years or so of USAID funding, if it still existed. This is how they’re spending our tax dollars. This is our money.
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- If you are looking for a distraction, this seems cool. Sticky ends++. If it works as advertised, seems like it could be a game-changer. www.nature.com/articles/s41...
- Reposted by Hiten MadhaniI am excited to offer a postdoctoral research position in my lab in Oxford studying the distribution of small RNAs during plant sexual reproduction. shorturl.at/7Goxt Reposts appreciated! Obligatory cat video to brighten your day. :-)
- Reposted by Hiten MadhaniRead the Save HHS open letter! www.savehhs.org/letter-we-wi...
- Reposted by Hiten MadhaniIt's time to identify those 23 people and begin the pressure on them. This administration will not stop, even if the courts order it. That much is clear.
- Reposted by Hiten MadhaniCalifornia just joined the World Health Organization. I love it.
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- Reposted by Hiten MadhaniThe language on multiyear funding (MYF) is ineffective. Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%. This is incredibly harmful to the US research workforce - especially early career.
- Reposted by Hiten MadhaniYES! A step in the right direction. After a horrendous year for science & the #NIH, it is imperative to protect it from political interference. NIH's success is due to decisions based on science, not political ideology. Science does not belong to politicians. 🧪 degette.house.gov/media-center...
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- Reposted by Hiten Madhani🧪IMPORTANT! This graphic explains how science all over the US is funded. Congress approved a 2% increase in the #NIH budget for FY 26. Buried in the bill- Shift of ~40% of grants to MYF. This will still result in a 35% DECREASE in the NUMBER of grants funded per yr. Russel Vought is behind this.
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- Reposted by Hiten MadhaniHouse Appropriations minibus bill funding NIH is out now. - $400M increase - Multiyear funding of new awards capped at 2025 levels. - No line item for BRAIN Initiative text here: docs.house.gov/billsthiswee... Screenshots from Dem summary and Sec 240 (multiyear funding text).
- Beautiful day for a ride!
- 49ers game off to a great start — if you are a Hawks fan…
- Reposted by Hiten MadhaniExplain to Congress how important it is to keep multiyear funding of NIH grants in the funding bill. This protects against Russell Vought's trick, which is to make this year's NIH budget cover multiple years of research in advance. Tell your Congresscritter. US Capitol switchboard: 202-224-3121.
- I need to find a better hobby. Any suggestions?
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- Reposted by Hiten MadhaniCongressman Aderholt from Alabama is the chair and he is apparently willing to help OMB here, adding report language (which is toothless) rather than including this in the law. If you are from Alabama, please contact his office and your Senators and share your thoughts. 2/3
- Reposted by Hiten MadhaniThe appropriations bill that includes NIH is being finalized. The Senate bill includes a bipartisan amendment from Senators Capito (WV) and Baldwin (WI) limiting multi-year funding of grants. The House version does not and OMB has issued a veto threat if the House includes such language. 1/3
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- Reposted by Hiten MadhaniA reminder as Congress finalizes NIH appropriations: the bill must limit multiyear funding (MYF), Vought's way of cutting the NIH budget without cutting the budget. MYF will devastate the research workforce. @safa-science.bsky.social wrote this in July. Still relevant: substack.com/@scienceandf...
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- Reposted by Hiten MadhaniJUST IN: Judge Mehta rules that Trump/Russ Vought's termination of environmental grants during the shutdown — targeted solely at states that voted for Kamala Harris — violated the 5th Amendment's Equal Protection clause and orders them restored. www.documentcloud.org/documents/26...
- Nice day for a ride!
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- Nice view!
- Interesting paper in Nature on the genetics of multicellularity in marine yeasts. The senior author was a postdoc on our floor at UCSF :) www.nature.com/articles/s41...
- "NIH leadership turmoil adds to politicization concerns" www.science.org/doi/10.1126/...
- No cavaties! Surprising given all the holiday treats I was forced to eat out of politeness.
- Nice day for a ride (to the dentist)!
- Reposted by Hiten MadhaniWe are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
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- New Year’s Eve stroll in the rain rewarded with a mutant duck sighting. Happy New Year to genetics and non-genetics friends alike! Let’s hope for a better year than 2025 (it’s a low bar)!
- Reposted by Hiten MadhaniBREAKING: The National Institutes of Health has agreed to evaluate grant applications that were wrongfully frozen due to the Trump administration’s ideological purge of biomedical research.
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- Reposted by Hiten MadhaniMore on the continuing purges at #NIH. Now 13 out of 27 institute directors have been gotten rid of. This is not normal. @jonathanwosen.bsky.social www.statnews.com/2025/12/27/n...
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- Nice paper from @robertife.bsky.social on how metabolism-induced H4K16 acylations correlate with (and may cause) chromatin opening through disruption of tail-acidic patch internucleosomal interactions. www.cell.com/molecular-ce...
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- Nice evening to visit friends with a view!
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- Reposted by Hiten MadhaniDoing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it. PhD students: choose someone you like to talk to!
- Reposted by Hiten Madhani⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
- Reposted by Hiten MadhaniThis could have been an email.
- Nice day for a ride!
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- Grantflation. If only the budget was coupled to the science CPI. grants.nih.gov/grants/guide...
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- Reposted by Hiten MadhaniHow to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...
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- Unfortunately I am…
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- Reposted by Hiten MadhaniFantastic seminar on 'chromatin regulation and evolution' by @hitenmadhani.bsky.social at @ucriverside.bsky.social Loved how he started with the classic Linaria vulgaris epigenetics example 🌱
- Cloudy (but nice) day for a ride!
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