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- 🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🧬What happens when #Yeast lose their peroxisomes? New #metabolomics study reveals they affect more than just fatty acid breakdown, but also influence lipid synthesis & polyamine homeostasis-expanding our view of peroxisome function #YeastResearch #SGD #OpenScience www.yeastgenome.org/reference/S1...
- 🧬 Overcoming glucose preference: Newly evolved #Yeast strain efficiently co-ferments glucose and xylose from plant biomass, producing ethanol with better redox balance and reduced xylitol formation 🧪 #YeastResearch #SGD #SustainableFuels www.yeastgenome.org/reference/S1...
- ⚡ Unconventional zinc finger binding! Newly solved structure shows #Yeast Fzf1 transcription factor uses non-canonical DNA binding strategy with its 5 zinc fingers; unusual binding pattern controls key stress response genes like SSU1 and YHB1 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🧬 Meet Sni445, a newly discovered #Yeast ribosome assembly factor! Ynl050c/Sni445 recruits specialized snoRNPs (snR4 & snR45) that guide precise rRNA acetylation during ribosome synthesis. Another piece of the puzzle solved! 🧪 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🧬 20 years ago, discovery of the EGO complex in #Yeast revolutionized understanding of nutrient signaling. New review explores how Rag GTPases link amino acids to TORC1 growth control, establishing blueprint for cross-species nutrient sensing 🔬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🔬 Study uncovers critical balance in #yeast mRNA export: Elevated Mex67-Mtr2 exporter levels in nuclear ribonucleoprotein particles impairs export efficiency, showing precise, not maximal, levels are needed for proper cellular function 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🔬 New #yeast paper! Eukaryotic ribosome assembly follows unique pathway distinct from bacteria: Rlp7 depletion experiments show foot structure factors are essential for proper rRNA domain compaction and r-protein incorporation 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🥊 Knocking out MNN11 glycosyltransferase in #yeast = ⬆︎ taxadiene synthase expression & boosts taxadiene yield. New #YeastResearch shows endogenous glycosylation modifications can limit heterologous protein function in #pharmaceutical precursor production. 🧬 #SGD www.yeastgenome.org/reference/S1...
- 🧬 New #YeastResearch shows Tif35 (eIF3g) recognizes specific RNA sequences - GUCG boxes - and boosts production of heat shock proteins during stress, revealing how #yeast cells selectively increase translation of protective genes when needed #SGD www.yeastgenome.org/reference/S1...
- 🔬Study reveals how #Yeast regulates mitochondrial DNA copy number: Mrx6 forms complex with Mam33 to modulate Lon protease Pim1 substrate specificity, controlling degradation of key mtDNA maintenance proteins Rpo41 and Cim1 www.yeastgenome.org/reference/S1... #YeastResearch #SGD #MitochondrialBiology
- 🧬 New #YeastResearch provides insights into chromosome segregation: Research shows Cdc5 & Cdc14 orchestrate timely resolution of sister chromatid intertwines by coordinating spindle elongation with DNA linkage removal through Top2 regulation #SGD www.yeastgenome.org/reference/S1...
- 🔬Surprising finding: Perturbing 2′-O-methylation at Gm1271 affects both ribosomal ac4C sites despite being spatially close to only one; reveals unexpected crosstalk in rRNA modification networks that correlates with altered translation fidelity #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🧬Novel flow cytometry method tracks fluorescent wt vs unlabeled mutant mtDNA inheritance in heteroplasmic #Yeast. Cells selectively eliminate defective mito genomes through local bioenergetic monitoring, even under non-respiratory conditions #SGD #YeastResearch 🔬 www.yeastgenome.org/reference/S1...
- 🧬 #YeastResearch on DNA mismatch repair: Study reveals Mlh1-Pms1 endonuclease directly catalyzes mispair excision through nicked-strand-specific cleavage. Research explains the universal requirement for Mlh1-Pms1 in preventing cancer-causing mutations. #SGD www.yeastgenome.org/reference/S1...
- New #YeastResearch into spliceosome assembly unlocks 🧬therapeutic potential for cancer & neurodegenerative diseases! Study reveals how conserved residues control spliceosome active site remodeling, identifying hotspots for structure-based drug design. www.yeastgenome.org/reference/S1... 🔬 #SGD
- New insights into ncRNA quality control! Research shows #yeast cells use mRNA guard proteins Npl3, Gbp2, Hrb1 and novel factor Lhp1 to monitor U6 snRNA maturation, while faulty RNAs are degraded to protect spliceosome function. 🧬 #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- 🔬New #YeastResearch: Comprehensive RNA-seq analysis looks at 🧬 expression changes in "a" mating type cells treated with α-factor. 957 DEGs were identified: 448 ⬆︎, 509 ⬇︎. This dataset includes novel candidates potentially involved in mating responses! www.yeastgenome.org/reference/S1... #SGD #APOYG
- How’s the #yeast community closing out 2025? SGD is saying a heartfelt farewell, revealing new Resource links, announcing a simple way to support the #Database you rely on, and more. Read our December newsletter: www.yeastgenome.org/blog/sgd-new... #SGD #science
