RSC Chemical Biology
A gold open-access journal focused on innovative chemical biology tools and their application in exploring and manipulating molecular biological processes.
🌐 Website: rsc.li/rscchembio Published by @rsc.org
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- 🧬 Can simple chemical modifications lead to brighter FIT-PNA probes for RNA sensing? In this Advance Article MK Gupta, S Maree, and E Yavin investigate the impact of incorporating γ-PNA monomers next to the BisQ fluorophore in FIT-PNA probes. 🔗 Read the full story: doi.org/10.1039/D5CB...
- We are sponsoring the RSC CBBG Forum with poster prizes from #OBC, #ChemicalScience, #RSCChemBio and #RSCMedChem! Poster Abstract deadline 6th February, so register now! 📆6th March 📍Cardiff University 🔗https://www.rsc.org/events/detail/82568/2026-rsc-chemical-biology-and-bio-organic-group-cbbg-forum
- This #WorldCancerDay @rsc.org is showcasing some exciting innovative cancer research published across our journals in 2025. One article on immunocytokine-constructs comes from Editorial Board member Sander van Kasteren 🔗The article: doi.org/10.1039/D5CB... 🔗The collection: pubs.rsc.org/en/jour...
- ⏱️"Does sod1 encode a #molecularclock?" Researchers at Baylor University investigate in this #openaccess Advance Article from #RSCChemBio 🔗Read the full story here: doi.org/10.1039/D5CB...
- 📢#RSCChemBio are pleased to sponsor poster prizes at the GDCh Biochemistry 2026 conference! 📆 16-18th March, 2026 📍 Hotel Melchior Park, Würzburg, Germany 🔗 www.gdch.de/biochemistry... Abstract submission deadline and early registration fee end today 28th January, so get registered now!
- 🦠 In their new #RSCChemBio article, Gianmarco Gasperini and his team report on their development of a novel selective conjugation strategy based on cytoplasmic protein glycoengineering! 👉 Read more about how this approach is advancing the design of glycoconjugate vaccines.
- ✨ From our newest #RSCChemBio themed collection, Zachary Rabinowitz and Seyedeh Alaleh Anvar introduce their hydrolase-targeting probes! 📢 Read more about their use of quinone-methide chemistry towards developing and tuning these probes here: doi.org/10.1039/D5CB... #FlourescentProbes
- New from King and Wakarchuk University of Alberta: examine the role of glycans in actinobacterial growth and physiology. This thought provoking review hopes to spark interest in developing new ways to probe these protein O-mannosylation in actinobacteria. Read the full story: doi.org/10.1039/D5CB...
- 📢New Advance Article: Stierhof et al. demonstrate that biosynthetic crosstalk between native and introduced biosynthetic gene clusters results in rare #NaturalProducts with complex chemical scaffolds🦠 📰Read the full story: doi.org/10.1039/D5CB... Antibiotikaforschung @uni-saarland.de
- First issue of 2026 is now online and #openaccess! In this issue: G-clamp based RNA-binding molecular probes, bacteriophage small molecule inhibitors, translation-enhancing peptide screening platforms, bioluminescent D-luciferin analogues and much more! 📰Read the full issue here: lnkd.in/eYSvHxtp
- 📢New Advance Article: Interested in a #CellFree protocol for subunit-specific protein labelling? Researchers at CNRS Biologie present a new protocol for producing deuterated or methyl-labelled complexes using cell-free technology. ➡️Read the full story: doi.org/10.1039/D5CB...
- 📢 #RSCChemBio is sponsoring two poster prizes at the EMBO-EMBL Chemical Biology Workshop 2026! 📅 8 - 11th September 2026 📍 EMBL Heidelberg, Germany 🔗 www.embl.org/about/i... Submit your abstract by 2nd June 2026 to a part of the event! EMBO #ChemicalBiology
- 📢New research from B Richichi et al presents Tris-BODIPY-OH as a universal scaffold for glycosylated #FluorescentProbes showing improved affinity for target lectins useful for studying lectin trafficking in vitro, in vivo and for #bioimaging applications 👉Get the full story
- Can enzyme activation convert selective kinase inhibitors into targeted prodrugs? Hinshaw, Gray et al. develop AKR1C3-activated prodrugs designed as targeted CDK11-inhibitors with potential to reduce cytotoxicity and improve the therapeutic window. ➡️ Get the full story:
- How can #GenomeMining accelerate the discovery of phosphonate #NaturalProduct producers?🦠 New research from @leibniz-dsmz.bsky.social and @unituebingen.bsky.social highlights actinomycetes as a rich source of novel bioactive phosphonates. 👉Read the full article here doi.org/10.1039/D5CB...
- Can we broaden the scope of core backbone engineering in proteomimetics? 🔎New research from WS Horne et al explores backbone variants of villin headpiece, demonstrating both core residues and solvent-exposed sites are fair game in developing proteomimetics ➡️Read it here:
- Exciting results in this Advance Article from researchers @unimont.bsky.social👇 How does a late-stage modification with salicylaldehyde tags enhance peptide affinity for nuclear factor-kappa B essential modulator (NEMO)? 👉Read the full article to find out:
- 📣New from @byronpurse.bsky.social et al at @sdsuresearch.bsky.social A nucleobase analogue that lights up only when it pairs right: DEAtC turns on fluorescence through G-templated tautomerism, switching from a dark T-like form to an emissive C-like tautomer. Read it here
- We are delighted to share news of an upcoming themed collection on biocatalysis across RSC Chem. Biol., @catalysisscitech.rsc.org, @rscadvances.rsc.org, @reactchemeng.rsc.org to celebrate the careers of Prof. Nicholas Turner and Prof. Sabine Flitsch of @manchester.ac.uk blogs.rsc.org/cb/biocataly...
- 📢2025 RSC Chemical Biology Emerging Investigators collection is now published online. This collection features invited contributions from early career researchers who are making significant contributions to the field of chemical biology. ➡️Read the full collection here: rsc.li/cbemi25
- ✨New advance article! Johansson et al. introduce FLORENCE, Fluorescence labelling in recoded E.coli with non-canonical chemical entities, a SMT labelling method based on genetic code expansion offering an alternative to HaloTag and SNAP-tag systems. ✨Read the full story
- 📢New from P Chaiyen et al. 🧪Introducing a one-pot synthesis of bioluminescent D-luciferin analogues that show enhanced light intensity, red-shifted #bioluminescence, and greater light stability - all advantageous for future monitoring applications! 👉Read the full story:
- Our final #RSCChemicalBiology newsletter of the year is now on the blog! 🧬✨ Catch up on award winners, research highlights, community events, themed collections, and upcoming conferences. Read the full update: blogs.rsc.org/cb/2025/12/0... Subscribe to our e-alerts here: www.rsc.org/publishing/j...
- We are pleased to sponsor Poster Prizes at the 34th GP2A Medicinal Chemistry Conference with @rscmedchem.rsc.org & @rscpharmaceutics.rsc.org 📅26-28 Aug 2026 📍Department of Chemistry and Molecular Biology, University of Gothenburg 👉Visit gp2a.org/index.php/gp... #GP2A #MedChem @omc-gu.bsky.social
- 📢Latest article out now! M Michel et al. used synthetic purine analogues to profile the nucleobase landscape of OGG1 looking for catalysts of the Schiff base cleavage, identifying two series that increased enzyme turnover and enhanced DNA damage repair. 👉Full story here:
- Reposted by RSC Chemical BiologyProfessor Kenneth Lo (City University of Hong Kong) joins as the new External Organiser for #RSCPoster 2026! His leadership will spark global collaboration, scientific discovery, and impactful conversations across the research community. Stay tuned for updates — #ChemSky
- 🔎How does seeding by proIAPP influence amyloid fibril structure in type 2 diabetes? Find out in the latest #openaccess Advance Article from Dylan Valli and Michal Maj at Uppsala University @uu.se ➡️Read the full story here:
- Reposted by RSC Chemical Biology[Not loaded yet]
- Reposted by RSC Chemical Biology[Not loaded yet]
- How does Nanchangmycin inhibit Zika virus infection?🦟 Find out in this new research from Emmanuelle Thinon et al. describing the "Affinity-based protein profiling of the antiviral natural product nanchangmycin". 👉Read the full story here: doi.org/10.1039/D5CB... #proteomics #openaccess
- #RSCChemBio Issue 12 is now online and #openaccess! In this issue: photoresponsive molecular tweezers, probing the role of LytG in cell wall metabolism, peroxidase-based proximal protein labelling, and much more! 📰Read the full issue here: pubs.rsc.org/en/journals/...
- 🧬New article out now! K Onizuka, F Nagatsugi et al introduce novel RNA-binding molecular probes by conjugating thiazole orange derivatives to G-clamp for applications in Fluorescent Indicator Displacement (FID) assays. ➡️Read the full paper:
- 📣Present your research at the 29th Enzyme Mechanisms Conference (4 – 8 Jan 2026) 🧪RSC Chem. Biol. is proud to sponsor a poster prize! 📅Poster abstracts due by 29th November 2025 – submit now! ➡️www.enzymemechanisms... #enzyme #ChemicalBiology
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- 📰 New article from Jani Bolla, Carol Robinson et al. from @ox.ac.uk Evaluating the feasibility of peptidiscs for native mass-spectrometry analysis and structural characterisation of membrane proteins and their assemblies. 👉 Read more at: doi.org/10.1039/D5CB...
- Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enzymes in their native environment. 👉 Read the full paper here: doi.org/10.1039/D5CB...
- Fresh from Yogo Sakakibara et al.! "Comparative aptamer profiling reveals cell surface remodeling under oncogenic signaling — including the unexpected surface appearance of a mitochondrial protein." 👉Read the full article here: doi.org/10.1039/D5CB...
- New in RSC Chemical Biology: Convergent construction of N-terminally modified CCL5 chemokines for photoaffinity receptor pull-down using cross-aldol bioconjugations by Martin Fascione et al., from @york.ac.uk Read the full paper here👉 doi.org/10.1039/D5CB...
- New research by Weijun Shen, Muyu Xu et al. at Shenzhen Bay Laboratory: "Cell-based high-throughput screening using a target–NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein" Read the full paper here👉 doi.org/10.1039/D5CB...
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- Reposted by RSC Chemical Biology[Not loaded yet]
- New from @llparker100.bsky.social et al. from @uminnpress.bsky.social Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays Read the full paper👉 doi.org/10.1039/D5CB...
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- Fresh from RSC Chemical Biology: Hao et al. from the Chinese Academy of Sciences: Structural basis of SIRT2 pre-catalysis NAD+ binding dynamics and mechanism Read more 👉 doi.org/10.1039/D5CB...
- Reposted by RSC Chemical BiologyIn honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆 Free to read until the end of November 👉 pubs.rsc.org/en/jour...
- New from Christopher Coxon et al., from @edinburgh-uni.bsky.social "19F NMR-tags for peptidyl prolyl conformation analysis" Fluorinated tags + 19F NMR = fresh insights into proline cis/trans isomerism, a key player in protein folding + interactions. Read the paper 👉 doi.org/10.1039/D5CB...
- Excited to support #ChemBioParis2025 this October 6 in Paris! Our Executive Editor, Anna Rulka + Associate Editors Claudia Höbartner and Zaneta Nikolovska-Coleska are attending—come say hi! Let’s connect and talk science and publishing! 🔗 chembioparis2025.com #ChemicalBiology #ICBS #ECBS
- 🧬 New study reveals how biosensors + crystallography can detect ligand-induced shape changes in ACh binding proteins—models for ion channels. A powerful toolkit for studying weak or fast interactions! Read here: doi.org/10.1039/D5CB... #RSCChemicalBiology #StructuralBiology #Biosensors
- 🦠 Can resistant bacteria protect their neighbours? A new paper reveals how β-lactamase activity, membrane permeability & antibiotic type shape antibiotic sheltering in microbial communities. Read it here: doi.org/10.1039/D5CB... #RSCChemicalBiology #AntibioticResistance #BetaLactamase
- RSC Chemical Biology was proud to support the next generation of researchers at the 21st Annual Tri-Institutional Chemical Biology Symposium! Congratulations to all the winners!
- Congratulations to Johannes Broichhagen (@broichhagenj.bsky.social) & team—winners of RSC Chemical Biology’s Outstanding Early Career Researcher Award for cleavable dyes to track GPCR trafficking & signalling! 📖 Read the paper here: doi.org/10.1039/D4CB...
- 🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation. Read here: doi.org/10.1039/D5CB... #RSCChemicalBiology #mRNA #RNAStability
- RSC Chem. Biol. & Molecular Omics are sponsoring the EMBL’s The Epitranscriptome (28–30 Oct)! 🗓️ Today (16 Sept) is the last day to register for on-site attendance – be part of it in person! (Virtual registration open until 13 Oct.) 👉 www.embl.org/about/i... #Epitranscriptome
- 🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery. doi.org/10.1039/D5CB... #PhageDisplay #ChemicalBiology #ClickChemistry
- 🚨 New paper on enhancing NIR-PIT for cancer treatment! SiPc-1, a silicon phthalocyanine analogue, targets HTLV-1-infected cells with selective toxicity. Find out how this breakthrough could shape the future of ATL treatment 👉doi.org/10.1039/D5CB... #RSCChemicalBiology #NIRPIT #CancerResearch
- 🧬 Explore our new collection Biomolecular Technologies! Guest edited by Sheel Dodani & Ariel Furst, it showcases advances in engineered small molecules, nucleic acids & proteins for biocatalysis, biosensing & synthetic biology. 🔗 Read now: rsc.li/cbbmt25
- 🧠 New bioconjugation trick for tracking serotonylation — no tryptophan needed! 📝 New work from Qingfei Zheng et al. 📄 "Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation" 🔗 Read the full paper:
- 🚨 Breakthrough in targeting cancer-related protein aggregation: "Random peptide mixtures of tryptophan and lysine suppress the aggregation of a cancer-related mutant of the Axin protein" by Assaf Friedler et al. 🔗 Read the full article:
