Bohdana Hurieva🇺🇦
PhD student @soreklab.bsky.social at Weizmann Institute of Science
Evolution of immune systems 🌱🦠
- Reposted by Bohdana Hurieva🇺🇦Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity! www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection. www.nature.com/articles/s41... www.nature.com/articles/s41...
- Incredible tool for structure-guided MSAs - happy to see it’s out!
- FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
- Reposted by Bohdana Hurieva🇺🇦FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
- Reposted by Bohdana Hurieva🇺🇦We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap A thread 🧵
- Reposted by Bohdana Hurieva🇺🇦🧬 Metabolic arms race continues! We discovered a new NAD⁺-depleting bacterial immune system aRES and phage enzymes that overcome it. Our preprint is out: www.biorxiv.org/content/10.6...
- New layers to the NAD+ immune arms race - it’s a never ending fight!🦠🧪 I was very happy to contribute to this story. Congratulations Ilya for an amazing discovery!!🎉
- 🧬 Metabolic arms race continues! We discovered a new NAD⁺-depleting bacterial immune system aRES and phage enzymes that overcome it. Our preprint is out: www.biorxiv.org/content/10.6...
- Reposted by Bohdana Hurieva🇺🇦My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring! mirdita.org
- Reposted by Bohdana Hurieva🇺🇦I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx
- Reposted by Bohdana Hurieva🇺🇦The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪 www.weizmann.ac.il/plants/voichek
- Reposted by Bohdana Hurieva🇺🇦NLR-like immunity in bacteria A new study from the Alex Gao lab. The scope of this work is incredible!!! www.biorxiv.org/content/10.6...
- Reposted by Bohdana Hurieva🇺🇦Happy to share that I’m opening my lab at the Weizmann Institute of Science! We’ll study systems-level regulation of bacterial defense, driven by RNA-protein interactions shaping cell fate. Now recruiting PhD students & postdocs tinyurl.com/4yfa55vd Please reach out and share!
- Reposted by Bohdana Hurieva🇺🇦Feeling festive? Why not deck the halls with @cvrinfo.bsky.social's papercraft #VirusSnowflakes and celebrate the science of viruses and the fight against viral diseases. Download for free: cvr-engagement.co.uk/virus-snowfl... #scicomm #sciart #decorations
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- New Thoeris systems reveal a deep connection between bacterial TIR-produced immune signals to plant and human immunity🦠🌱🧍♀️ It was a great honor to contribute to this project! Congratulations to @erezyirmiya.bsky.social and Azita Leavitt!!🎉🥂
- I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life. www.biorxiv.org/content/10.6...
- Reposted by Bohdana Hurieva🇺🇦🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...
- Very excited to join the upcoming meeting this May!🦠🧫
- Check this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed) sisb2026.rockefeller.edu
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- Reposted by Bohdana Hurieva🇺🇦🧬🛡️How are new immune mechanisms created? We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org. 👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors! doi.org/10.1073/pnas...
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- Great structural study expanding on the role of NAD-cleaving sirtuins in humans
- Reposted by Bohdana Hurieva🇺🇦📣 New preprint from us at phagefoundry.org 📣 A solid machine learning framework & to predict strain-level phage-host interactions across diverse bacterial genera from genome sequences alone. Avery Noonan from the Arkin Lab led this massive effort www.biorxiv.org/content/10.1...
- Reposted by Bohdana Hurieva🇺🇦NEW pub in @science.org 🥳 Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life? For over 15 years, #phylogenomic studies have been divided. We provide new evidence suggesting that... 🔗: www.science.org/doi/10.1126/...
- Reposted by Bohdana Hurieva🇺🇦Congratulations to Sorek lab alumnus Nitzan Tal, who won the prestigious 2025 Science & SciLifeLab prize for the best PhD thesis in Systems Biology! 💫 Read her Prize Assay, published in the journal Science today www.science.org/doi/10.1126/... @nitzantal.bsky.social
- Reposted by Bohdana Hurieva🇺🇦Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
- Reposted by Bohdana Hurieva🇺🇦Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis www.nature.com/articles/s41... this project was led by @omernadel.bsky.social and is a joint work between the labs of @bejalab.bsky.social, Debbie Lindell and Oded Kleifeld from @biologytechnion.bsky.social
- Reposted by Bohdana Hurieva🇺🇦📖Latest from the lab: Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n www.nature.com/articles/s41...
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- Reposted by Bohdana Hurieva🇺🇦An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
- Reposted by Bohdana Hurieva🇺🇦After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
- Amazing discovery by @ostermanilya.bsky.social - two systems that can detect methylated mononucleotides after genome degradation! Watching Ilya decipher this mechanism was a masterclass of scientific detective work - and I was happy to contribute a bit with a phylogenetic perspective🔎
- Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇 www.biorxiv.org/content/10.1...
- Reposted by Bohdana Hurieva🇺🇦Hi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79). Update time ! Send me a message to 1) add your lab or others 2) Correct info docs.google.com/spreadsheets... #Phagesky #Microsky
- Reposted by Bohdana Hurieva🇺🇦Last year it was discovered that a single bacterial NLR-like protein can recognize multiple, structurally unrelated phage proteins (Béchon et al, Kibby et al) Now, a new study shows the same for a plant NLR. Another example how principles of immunity remain conserved from bacteria to eukaryotes
- A wheat NLR conferring broad-spectrum resistance against powdery mildew by recognizing two structurally diverse AVR effectors. Interested? Check out our newest preprint: www.biorxiv.org/content/10.1...
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- Reposted by Bohdana Hurieva🇺🇦🚨 Systems Virology Journal Club – 8th Series! 🚨 #BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
- Reposted by Bohdana Hurieva🇺🇦Perfect timing in the field for a beautiful review on NAD+ in bacterial immunity by @hugovaysset.bsky.social and @audeber.bsky.social @cp-molcell.bsky.social #MicroSky www.cell.com/molecular-ce...
- Reposted by Bohdana Hurieva🇺🇦We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social rdcu.be/eLbaZ
- Reposted by Bohdana Hurieva🇺🇦A little late to the Panoptes party, but I’m delighted to share that our paper is published! 👁️ www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Viral AlphaFold Database (VAD) is live in Science Advances ~27,000 predicted viral protein monomers & homodimers Conserved folds across bacteria, archaea & eukaryotic viruses New toxin–antitoxin system KreTA uncovered Vast “functional darkness” remains uncharted www.science.org/doi/10.1126/...
- Reposted by Bohdana Hurieva🇺🇦Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦Very important paper and resource. Bryophyte genomes expanded by one order of magnitude. www.nature.com/articles/s41...
- Reposted by Bohdana Hurieva🇺🇦MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n 📄 www.nature.com/articles/s41... 💿 mmseqs.com
- Reposted by Bohdana Hurieva🇺🇦hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
- Reposted by Bohdana Hurieva🇺🇦Phage "satellites" that produce capsids but have no genes to produce tails have puzzled scientists for a long time. These are abundant as prophages in bacteria, but it was unclear how they can infect without tails Now, Penadés & co show that they hijack tails from other phages. Incredible!
- Thrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...
- Reposted by Bohdana Hurieva🇺🇦Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
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- Reposted by Bohdana Hurieva🇺🇦Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...
- Reposted by Bohdana Hurieva🇺🇦How can we understand the earliest events in evolution of eukaryotic immunity? @yao-li.bsky.social reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense www.biorxiv.org/content/10.1...
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- Reposted by Bohdana Hurieva🇺🇦Preprint: De-novo design of proteins that inhibit bacterial defenses Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications Congrats Jeremy Garb! tinyurl.com/Syttt 🧵
- Reposted by Bohdana Hurieva🇺🇦📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...
- Reposted by Bohdana Hurieva🇺🇦An inspiring read! academic.oup.com/genetics/adv... A beautiful historical perspective on Ester Lederberg's legacy from @ccwendling.bsky.social & @zacharybailey.bsky.social
- Reposted by Bohdana Hurieva🇺🇦New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...
