Ashley Sullivan
🦬 // PhD candidate in the Aaron Whiteley Lab at CU Boulder. she/her
- A little late to the Panoptes party, but I’m delighted to share that our paper is published! 👁️ www.nature.com/articles/s41...
- Huge shoutout and thanks to my lab mates in the @aaronwhiteley.bsky.social lab and our collaborators in the @benmorehouse.bsky.social lab. This work would not have been possible without you all! 🫶🏻
- Reposted by Ashley SullivanMy pleasure @erinedoherty.bsky.social and @benmorehouse.bsky.social - for me this was the stand-out discovery of the last year in the field
- And thanks to @mfwhite2.bsky.social for this great perspective on both works! www.nature.com/articles/d41...
- Reposted by Ashley SullivanVery excited to see our work appear alongside findings from @aaronwhiteley.bsky.social & @benmorehouse.bsky.social ! www.nature.com/articles/s41...
- Reposted by Ashley SullivanNow online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...
- Reposted by Ashley SullivanThank you to everyone who helped make this story happen! Obligatory meme to summarize: “How I imagine phage facing CBASS and mCpol”
- Reposted by Ashley Sullivan[Not loaded yet]
- Reposted by Ashley SullivanA new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity. www.biorxiv.org/content/10.1...
- Reposted by Ashley SullivanPreprint: “Structural modeling reveals viral proteins that manipulate host immune signaling” Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules Congrats Nitzan Tal! www.biorxiv.org/content/10.1...
- Reposted by Ashley SullivanI am delighted to share that my work in the @aaronwhiteley.bsky.social lab is now on bioRxiv! We used a large-scale genetic screen to begin defining the vast landscape of phage proteins that trigger immune signaling in bacteria. www.biorxiv.org/content/10.1...
- Reposted by Ashley SullivanExcited to share that my work in the @aaronwhiteley.bsky.social lab describing chaperone-mediated phage sensing by a bacterial NLR-related protein is out in @plosbiology.org!
- Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪 plos.io/4koXP60
- Reposted by Ashley SullivanCBASS, CRISPR, and mCpol- oh my! What a satisfying collaboration with @aaronwhiteley.bsky.social 's lab- we uncovered a new cyclic dinucleotide signaling pathway, but it doesn't work how you'd expect! Check out the thread from @aesully98.bsky.social for an overview of the most important findings!
- Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
- Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
- Nucleotide-based signaling is a hallmark of many antiphage systems (CBASS, Pycsar, Thoeris, etc.). Here we investigated Panoptes, a two-gene operon (optSE) that we predicted would similarly use nucleotide second messengers to carry out an immune response.
