Patrick Pausch
Research Professor & Group Leader at Vilnius University, LSC-EMBL - CRISPR, Gene Editing and Microbiology
- Reposted by Patrick Pausch🔔HIRI has opened a new call to recruit Group Leaders. If you are interested in opening an RNA Biology and Infection lab, join us! Deadline: February 15. More info here 👇
- Reposted by Patrick Pausch🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...
- Reposted by Patrick PauschWe are looking for a junior group leader in RNA biology to join us in Würzburg at the @helmholtz-hiri.bsky.social ! A generous funding package, a great collaborative environment, and a beautiful city are all included :) Deadline for application is Feb 15; more information below 👇
- Reposted by Patrick PauschTo those American academics out there who have chosen to remain silent/mostly silent about the horror going on in the USA these days at every corner of the federal government, please start speaking out and fighting back.
- Reposted by Patrick PauschGreat opportunity to join the lab of @patrick-pausch.bsky.social ! www.linkedin.com/feed/update/...
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- Reposted by Patrick PauschThis work constructed a large library of 406 vectors that individually express nearly every protein from 6 phages. We hope this resource will be broadly useful to the field and have deposited a version at Addgene (ID 249629). It should be available soon!
- Reposted by Patrick PauschI’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Patrick PauschPreprint out: We characterise PUA-Cal-HAD, a widespread bacterial antiphage defence family. An infection cue switches a preassembled complex into an immune filament that drains dNTPs via a coupled two-enzyme cascade, and phage DNA mimics can block filament assembly (anti-polymerisation).
- Reposted by Patrick Pausch📢 We are hiring 📢 1st round of recruiting for our ERC project BacImmune-Decode! @erc.europa.eu We are looking for a postdoc for wet-lab work on regulation of phage defence systems in bacteria using high-throughput microbial genetics. Check it out: lnkd.in/es7AE968 #Hiring #Postdoc #Microbiology
- Reposted by Patrick PauschHappy to share our recent preprint: "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" www.biorxiv.org/content/10.6... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
- Reposted by Patrick PauschOur paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
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- Reposted by Patrick PauschLooking for a POSTDOC to work on jumbo phages (those with large genomes and fascinating cell biology), using our latest ASO technology (Gerovac M et al. 2025 Nature) to define RNA export mechanisms as well as to help to advance phage therapy. Here's the job ad.
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- Reposted by Patrick Pausch✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- Reposted by Patrick PauschPhages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out tinyurl.com/bdcfrejh
- Reposted by Patrick Pausch📢 We have multiple open PhD positions to study bacterial immune systems using cutting-edge cryo-EM, microbiology, and biochemistry in our group! Join us and uncover how bacterial defenses eliminate predators and engineer next-gen biotech tools. 🔥 Apply by Jan 8, 2026 Details: phd.pages.ista.ac.at
- Reposted by Patrick PauschCheck this out for the 2026 SISB (phage defense) meeting in NYC. Mark your calendar! (and note the Zoom option, if needed) sisb2026.rockefeller.edu
- Reposted by Patrick Pausch🚀New preprint from our lab! I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡 Continue reading (🧵)
- Reposted by Patrick Pausch🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
- Reposted by Patrick PauschIT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
- After 5 years of waiting, the new #CRISPR classification by Makarova et al. is out @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Patrick PauschUse antisense oligomers to silence phage genes and discover new biology. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de print: www.nature.com/articles/s41... highlight: www.nature.com/articles/s41... briefing: www.nature.com/articles/d41...
- Reposted by Patrick Pausch🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of: 🔵 RNA Biology 🔵 RNA Medicine 🔵 RNA Technology Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale... Find an overview in this thread. 🧵👇 (1/6)
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- Reposted by Patrick PauschI'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
- Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...
- Reposted by Patrick PauschAre you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab! For more information and how to apply, see below 👇 Please RT!
- 📢 The #HIRI is looking for a #postdoc & a #PhD student to join the research group of @jenshoer.bsky.social. His lab focuses on understanding the molecular mechanisms of #phages with #RNA genomes during infection, host takeover & anti-phage defense. 🧫🦠 More info: www.helmholtz-hiri.de/en/jobs-tale...
- Reposted by Patrick PauschGenome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria. doi.org/10.1101/2025...
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- Reposted by Patrick PauschPlease RT: We have an opening for a junior group leader position in „Phage Biology & Biotechnology“. www.fz-juelich.de/de/karriere/... Interested candidates are encouraged to contact me via email for further details. @spp2330.bsky.social; @mibinet.bsky.social
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- Reposted by Patrick PauschTwo group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
- Reposted by Patrick PauschNow online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...
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- Reposted by Patrick PauschNo Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @uni-wuerzburg.de @helmholtzhzi.bsky.social published now in @nature.com
- Reposted by Patrick PauschLooking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
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- Reposted by Patrick PauschExcited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
- Reposted by Patrick Pausch🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
- Reposted by Patrick PauschI am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
- Reposted by Patrick PauschA new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity. www.biorxiv.org/content/10.1...
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- PhDs, Postdocs and young PIs listen up! Next to connecting young scientists, we organised an engaging Night Science 💫 workshop (by @itaiyanai.bsky.social and Martin Lercher), and an epic social event at one of Vilnius’ best venues 🍻 .
- This year's EMBO Young Scientists’ Forum (EYSF) will take place in Vilnius, LT from 24–26 Sep 2025. The EYSF brings together scientists across #Europe for #networking and scientific exchange – Apply now! 🧪 Abstract submission by 1 Aug Registration by 15 Aug meetings.embo.org/event/25-eysf
