Dorentina Humolli
PhD student studying phage-host interactions at ETH Zürich | Lab of Molecular Phage Biology
- Reposted by Dorentina Humolli🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
- 🚀New preprint from our lab! I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡 Continue reading (🧵)
- First the link to the preprint: www.biorxiv.org/content/10.1...
- Phages are major players in microbial ecosystems but most of their genes have no known function. This ”viral dark matter” has been hard to study because we have lacked scalable ways to link phage genes to what they actually do.
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View full threadHuge thanks to @aharms485.bsky.social who made this work possible. It has been a privilege to tackle something this ambitious together. And big thanks to all co-authors Jessica Ransome, @damienpiel.bsky.social , @veeninglab.com for their amazing contributions!
