BaumjohannLab
Research on T and B cells in immunity and autoimmunity in the lab of Dirk Baumjohann at University Hospital Bonn & Cluster of Excellence ImmunoSensation @immunosens.bsky.social #TfhCells #GCs #ImmuneOrganoids
https://BaumjohannLab.de
- Reposted by BaumjohannLabEver wondered what happens if you remove Tfh cells from established germinal centres?
- Reposted by BaumjohannLabThrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...
- Reposted by BaumjohannLabFinally, my PhD project is published! 🎉 I am thankful to all the collaborators who made this possible! www.nature.com/articles/s41... @natcomms.nature.com #dendriticcells #immunesynapse #centrosome
- Looking forward to two exciting talks by @carovinuesa.bsky.social and Dirk Elewaut in the EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET t-cells.eu
- Reposted by BaumjohannLab@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
- Reposted by BaumjohannLab🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...
- Reposted by BaumjohannLab🎉 The new yEFIS website is now live! 🌐 We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/
- Reposted by BaumjohannLab@biorxivpreprint.bsky.social Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses www.biorxiv.org/content/10.6...
- Reposted by BaumjohannLab@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social www.biorxiv.org/content/10.1...
- Reposted by BaumjohannLabThe Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network. During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
- Reposted by BaumjohannLab@natrevimmunol.nature.com Guidelines for T cell nomenclature www.nature.com/articles/s41...
- Reposted by BaumjohannLab🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
- Reposted by BaumjohannLabRegistration is open for the Spring School on Immunology, hosted by DGfI March 15–20, 2026 | Ettal, Bavaria 🎓 An intensive training course for PhDs, postdocs & clinician scientists Apply by 15 Nov 2025 → loom.ly/LxBXUfI @dgfi-org.bsky.social
- Reposted by BaumjohannLabICYMI: Engineering and biofabrication of early cancer models
- Reposted by BaumjohannLab@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses www.biorxiv.org/content/10.1... @thelundlab.bsky.social @nyulangone.bsky.social @carlanowosad.bsky.social
- Reposted by BaumjohannLabWhat mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)? In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13. www.biorxiv.org/content/10.1... 1/n #Nephsky 🧪
- Reposted by BaumjohannLab🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
- Reposted by BaumjohannLabArai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
- Reposted by BaumjohannLabLooking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
- Reposted by BaumjohannLabAsthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here: www.biorxiv.org/content/10.1...
- Reposted by BaumjohannLab
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program. Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin. 👉 Apply now: www.mdc-berlin.de/career/jobs/... - Reposted by BaumjohannLabThanks @10xgenomics.bsky.social for the shout out and for making your data publicly available Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go (Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
- How do cytokines tune immune helpers? Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity. 🔗 www.nature.com/articles/s41... #Immunology #SpatialBiology
- Reposted by BaumjohannLabTemporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
- Reposted by BaumjohannLabA small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
- Reposted by BaumjohannLabThe Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to: Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance”
- Reposted by BaumjohannLabBREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize
- Reposted by BaumjohannLabIf the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
- Reposted by BaumjohannLabHappy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...
- Reposted by BaumjohannLabAmyotrophic lateral sclerosis is associated with autoimmune CD4 T cell recognition of C9orf72 & release of IL-5 and IL-10, w/ IL-10 correlating with longer survival www.nature.com/articles/s41... @nature.com @lji.org @settelab.bsky.social @columbiauniversity.bsky.social
- Reposted by BaumjohannLab🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights. 🔗 www.biorxiv.org/content/10.1...
- Reposted by BaumjohannLabWe’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...
- Reposted by BaumjohannLab🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
- Reposted by BaumjohannLabGreat to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
- So happy to share that our review in #ImmunolRev is finally out! 😃 We discuss how the immune system builds specialized TLSs across organs and conditions. Huge thanks to @StephanGuillaume, @iannaconelab.bsky.social & @linterman.bsky.social for this collaboration! dx.doi.org/10.1111/imr.70063
- Reposted by BaumjohannLabProgression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation www.science.org/doi/10.1126/...
- Reposted by BaumjohannLabFor our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by BaumjohannLabWe are seeking a Postdoctoral Researcher to join our group at the University Hospital Bonn / DZNE. The project will focus on spatial omics approaches to study how lipid transport and the immune system shape neurodegeneration. DM me here
- Reposted by BaumjohannLabCongratulations to Carola García de Vinuesa on receiving the 2026 FEBS | EMBO #WomenInScience Award! She is recognized for advancing the understanding of autoimmune diseases and for her impact within the #LifeSciences community, in particular in public engagement: www.embo.org/press-releas... 🧪
- Reposted by BaumjohannLabNew content online:
- Reposted by BaumjohannLab🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
- Reposted by BaumjohannLabLoss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by BaumjohannLabTissue-specific clonal selection and differentiation of CD4+ T cells during infection biorxiv.org/content/10.1101/202…
- Reposted by BaumjohannLabOur study in Science Translational Medicine sheds light on a new function of follicular regulatory T cells as unexpected allies in neuroinflammation. Grateful to our team members and collaborators. | www.science.org/doi/10.1126/...
- Reposted by BaumjohannLabCommon origins of autoimmune diseases and lymphoid malignancies #immunology
- Reposted by BaumjohannLabFoxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells biorxiv.org/content/10.1101/202…
- Reposted by BaumjohannLabStem-like peripheral helper T cells seed effector peripheral helper T cells in rheumatoid arthritis @sciimmunology.bsky.social www.science.org/doi/10.1126/...
- Reposted by BaumjohannLabThis week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover! scim.ag/3UqRrA6
- Reposted by BaumjohannLabOnline Now: T’s to the rescue: Expanding the follicular T cell universe in follicular lymphoma
- Reposted by BaumjohannLab🚨 #Job alert! The group of Johannes Brägelmann at the Medical ClinicIII at the University Hospital in Bonn is offering 2 PhD positions: 1) PhD in Cancer Immunology Link: www.immunosensation.de/opportunitie... 2) PhD in Spatial Cancer Biology Link: www.immunosensation.de/opportunitie... Apply now!
- Reposted by BaumjohannLabT’s to the rescue: Expanding the follicular T cell universe in follicular lymphoma www.cell.com/cancer-cell/... @cp-cancercell.bsky.social PREVIEW of www.cell.com/cancer-cell/...
- Reposted by BaumjohannLabDid you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)
- For a quick summary, read the Research Briefing here: www.nature.com/articles/s41...
- Reposted by BaumjohannLabGerminal centre formation is resilient to CD69 deletion on Tfh onlinelibrary.wiley.com/doi/10.1111/...
