Michelle Linterman
Programme Leader @malaghan.bsky.social & Associate Group Leader @babrahaminst.bsky.social, working on germinal centres, vaccines and tertiary lymphoid structures.
- Ever wondered what happens if you remove Tfh cells from established germinal centres?
- We did. We wanted to disentangle the role of Tfh cells in GC formation from their ongoing maintenance, so we used a Il21cre iDTR approach to delete Tfh cells from established GCs. Our hypothesis was that the GC would collapse, but it was surprisingly resilient.
- The GCs contracted, because of the lack of Tfh cells to support ongoing B cell proliferation, but then recovered when Tfh cells repopulated the GC. Resulting normal output and affinity maturation.
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View full threadWork led by Louise Webb now out www.science.org/doi/10.1126/... A huge team effort: Helena Carslaw, Jess James, @emae-watson.bsky.social, Silvia Innocentin, Jayalini Assalaarachchi, Sigrid Fra-Bido, Isabel San Martín Molina, @smguillaume.bsky.social , Sam Woolliscroft, Alice Burton & Grant Kennedy
- Thanks for highlighting our work 🙏 Project led by Louise Webb @babrahaminst.bsky.social
- Germinal center responses can recover from transient loss of T cell help, but the sustained reduction in TFH cells impairs recall responses @sciimmunology.bsky.social www.science.org/doi/10.1126/... @babrahaminst.bsky.social @linterman.bsky.social
- Thank you Fiamma. So good to be at LUMC and the NVVI this week. Great science, and great company!
- What a joy to host Michelle @linterman.bsky.social at the LUMC and spend more time together at the #NVVI!! She shared wonderful work on ectopic Germinal Centers in the lung (www.pnas.org/doi/10.1073/...) and a new exciting story that I can't wait to see published soon!!
- Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
- So happy to share that our review in #ImmunolRev is finally out! 😃 We discuss how the immune system builds specialized TLSs across organs and conditions. Huge thanks to @StephanGuillaume, @iannaconelab.bsky.social & @linterman.bsky.social for this collaboration! dx.doi.org/10.1111/imr.70063
- Reposted by Michelle LintermanSave the date! Keystone Stromal Immunology meeting, Feb 2-5, 2026 #KSStromal26 1. Scholarships/Short Talk Abstracts: October 7 2. Early Registration: December 3 (Save $200!) 3. Poster Abstracts: January 12, 2026 (11:59 MST) Please share! And reach out if you have any questions. Can't wait!
- It was great to be back at the @babrahaminst.bsky.social this week to spend time with the team talking about our science, and even managed a (very well timed) paper celebration! Amazing Tfh/GC themed brownie from Jess James.
- Thank you @immunologyking.bsky.social & @maurogaya.bsky.social for organising the #EMBObarrierTissues meeting in Basel this week. Great science, great people, great atmosphere ❤️
- Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...
- @pallettlab.bsky.social showing exciting new data on liver TRMs @linterman.bsky.social with great insights into lung GC B cells (yes actual lung GC!) @carlanowosad.bsky.social showing such pretty confetti GCs along with an amazing analogy for LN organisation and concerts in stadiums 😅 🤩👏
- Beautiful talk from @mahimaswamy.bsky.social at #EMBObarrierTissues. Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes | bioRxiv share.google/UroEHTZJI7tk...
- Fantastic @embo.org young investigator lecture on lung B cell responses from @maurogaya.bsky.social #EMBObarrierTissues
- Thank you Cris 🙏 Credit to Alyssa Silva Cayetano and Theresa Pankhurst for leading these research projects
- Amazing talk by Michelle @linterman.bsky.social at @iuis-online.bsky.social 2025 on ageing and immune responses to vaccines, shedding light on how understanding these mechanisms can guide the development of better immunization strategies
- Absolutely fantastic to have @labliston.bsky.social visiting the @malaghan.bsky.social this week. Beautiful talk on harnessing the power of Tregs to promote tissue repair, as well as many scientific discussions, an award ceremony at @nzparliament.bsky.social and multiple runs up our hills!
- A pleasure to have you in Aotearoa New Zealand to celebrate science!
- Great event at @nzparliament.bsky.social for Medicines New Zealand, with lots of exciting innovations in medical research on display. Thanks to @linterman.bsky.social from @malaghan.bsky.social for the invite!
- Fantastic to have Johanne Jacobsen at @malaghan.bsky.social this week presenting her beautiful work on germinal centre T cells, in all their complexity.
- Finally, after moving halfway across the world to beautiful Aotearoa New Zealand, our (Italian) espresso machine has arrived. Even better that we can get tasty beans from Acme who also make a special @malaghan.bsky.social blend that supports our research ❤️ lnkd.in/gbWi6RuW
- Great to have the @jimmunol.bsky.social special collection, “Aging's impact on the immune system” out. academic.oup.com/jimmunol/pag...
- Reposted by Michelle LintermanHighlights of 2024: unleashing the power of NK cells—cancer's worst nightmare onlinelibrary.wiley.com/doi/10.1111/...
- Reposted by Michelle Linterman🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues
- Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...
- Can't wait! I'm really looking forward to this meeting, so many amazing talks. Thanks @maurogaya.bsky.social @immunologyking.bsky.social @embo.org for organising ❤️ #EMBOBarrierTissues
- Dr. Michelle Linterman from the Malaghan/Babraham Institutes 🇳🇿🇬🇧 will be presenting her work on "Function and maintenance of lung germinal centres". Check her recent study on how lung B cells undergo affinity maturation: pubmed.ncbi.nlm.nih.gov/40168127/ @linterman.bsky.social #EMBOBarrierTissues
- Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...
- Thank you for the @thelisterinstitute.bsky.social support for this project! We couldn't have done it without you.
- A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...
- Reposted by Michelle LintermanLung B cells in ectopic germinal centers undergo affinity maturation www.pnas.org/doi/10.1073/... @linterman.bsky.social @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social
- Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
- Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
- Lung germinal centres are smaller and less densely packed with cells that those in lymph nodes, but despite this @sanmarti92.bsky.social @smguillaume.bsky.social and @wsfoster.bsky.social were able to show they still showed light and dark zone polarisation.
- @smguillaume.bsky.social used single cell sequencing to show that after NP-KLH/house dust mite treatment, lung germinal centre B cells were able to acquire high affinity B cells, although this was not as fast as in the lymph node germinal centres.
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View full threadFrom analysis of clones from the lung and the lymph node, it was clear that lung B cells may directly seed local lung memory B cell responses, which @smguillaume.bsky.social was able to show in vivo by blocking lymphocyte egress from lymph nodes with FTY720.
- Thanks to @zanivanlab.bsky.social , Max Mazzone and the Forbeck Research Foundation for a fantastic Forum on Harnessing stroma immune interactions for anti-cancer therapy. I learnt a huge amount from the participants and all the discussion. www.forbeckforums.org/forums/harne...
- Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...
- Thanks for highlighting our work. Credit goes to @wsfoster.bsky.social and Edith Marcial-Juárez for bringing this together
- Thanks for the shout out. Credit to William Foster and Edith Marcial-Juárez for leading on this review.
- Terrific #ImmunoAgeing Review @jimmunol.bsky.social from @linterman.bsky.social & friends @babrahaminst.bsky.social "Thanks for the #Memory" #Bcells #GerminalCenter #Immunity #Infection #Vaccination #Antibodies
- Reposted by Michelle LintermanAre you ready for it? "Highlights of 2024: γδ T cells and bad blood" A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis. And it may also contain a few Taylor Swift references. More than 50 in fact. Thank you so much @immunolcellbiol.bsky.social for playing along!
- Really nice @eurjimmunol.bsky.social paper from Karina Silina & @marieszh.bsky.social labs on the IFN-Lymphotoxin-Cxcl13 axis in forming tertiary lymphoid structures in the lung doi.org/10.1002/eji....
- Reposted by Michelle LintermanPostdoc Theresa Pankhurst is redefining leadership! As a Kia Niwha Leader Fellow, she is exploring leadership through the lens of Māori history, culture, and perspectives. “Leadership takes many forms,” she says—and she’s proving it every day 🙌 #IWD2025 @linterman.bsky.social @malaghan.bsky.social
- Really looking forward to this FEBS workshop on Immunology, Metabolism and Ageing. Sep 08 – 11, 2025 │ Matrei am Brenner, Austria immunologymetabolismageing2025.febsevents.org
- Reposted by Michelle LintermanHappy #FluoresenceFriday and happy Valentine's day ❤️ We love the @linterman.bsky.social for sharing this image of a mouse lymph node 📸 Emily Watson
- Reposted by Michelle LintermanInvest in your potential with our Career Enhancing Grants 🙌 These grants are here to support you in navigating the world of #immunology and reaching new heights in your #career 🚀 Apply now! bit.ly/3QedNDL Deadline: 27 March
- Reposted by Michelle LintermanFiamma Salernos latest manuscript available online. Some more science to follow
