Fiamma Salerno
Molecular Immunologist || T & B cell enthusiast || RNA-binding protein lover
Tenure-track group leader @LUMC Leiden
- Reposted by Fiamma SalernoEver wondered what happens if you remove Tfh cells from established germinal centres?
- What a joy to host Michelle @linterman.bsky.social at the LUMC and spend more time together at the #NVVI!! She shared wonderful work on ectopic Germinal Centers in the lung (www.pnas.org/doi/10.1073/...) and a new exciting story that I can't wait to see published soon!!
- mTOR regulates translation of cytokines through AU-rich elements within their 3′UTR! Great new work from the @monikawolkers.bsky.social lab!
- 👇See our newest study: What was supposed to be a control experiment uncovered a new function of mTOR: 3’mediated translation control in primary human T cells, mediated through DDX21. AU-rich elements are required for this effect. Happy reading! authors.elsevier.com/a/1mDFf3vVUP...
- Reposted by Fiamma SalernoGerminal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis @sciimmunology.bsky.social @martint-babraham.bsky.social www.science.org/doi/10.1126/... @babrahaminst.bsky.social
- 🚨 New paper alert!! RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells. A new mechanism showing how post-transcriptional control keeps our immune cells in check! #RNA #Bcells #GenomeStability www.science.org/doi/10.1126/...
- special thanks to all my collaborators! in particular to my former supervisor @martint-babraham.bsky.social
- This is great!
- Exciting news for the RNA research community! The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130... #RNA #bioinformatics #RNAstructure #modomics
- I am deeply honored and humbled to receive the 2025 KNAW Early Career Award from the Royal Netherlands Academy of Arts and Sciences! 🌟 This recognition means a lot, especially as a scientist working on fundamental immunology. Grateful to everyone who has supported and inspired me along the way! 🙏🏼
- Happy to share the first pre-print of the lab! 📢 💡Do you want to know how CD4 T cells decide their fate? We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation. www.biorxiv.org/content/10.1...
- Reposted by Fiamma Salerno@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Fiamma SalernoThrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...
- Reposted by Fiamma Salernoit is finally out! 👇 our #ML pipeline SONAR, which can predict the protein abundance in #immune cells. Using sequence features present in the #RNA. With @bnicolet.bsky.social Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social www.science.org/doi/epdf/10....
- Congratulations to you all! It's a pleasure to see this beautiful work online 🎉 ZFP36-family of RNA-binding proteins enables Treg cells to enforce immune homeostasis. www.nature.com/articles/s41...
- We celebrate the first birthday of the lab! 🎂 Stay tuned for the great science we have in the pipeline 🎉
- Always great to be at the EMBL! Looking forward to a full day of exciting science! #EMBLRBP
- Reposted by Fiamma SalernoAmazing stuff from @marvintanenbaum.bsky.social! Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex... #RNAsky #RNABiology
