
Design principles of lipid nanoparticles for RNA delivery
Nature Reviews Bioengineering, Published online: 02 February 2026; doi:10.1038/s44222-026-00401-1Lipid nanoparticles can serve as carriers for RNA therapies, enabling efficient encapsulation, cellular uptake and controlled protein expression. This Review explores their design principles, key components, physicochemical properties and therapeutic potential, highlighting how formulation parameters influence delivery performance.