Broad Institute
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
- On Tuesday, February 24 at 6PM ET join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26
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- Congratulations to @zhangf.bsky.social for being inducted into the National Inventors Hall of Fame!
- Join us on Tuesday, February 24 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26
- Our genes play a role in determining the microbial community living in our mouths, according to a new study that analyzed over 12,500 oral microbiome profiles. Researchers found interactions between human & bacterial DNA that could influence dental health.
- A new gen-AI model, called DNA-Diffusion, creates short DNA sequences capable of turning genes on or off in specific cells. The researchers hope that the technology could one day be part of gene therapies to treat disease.
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Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! www.cell.com/cell-genomic... #fibrosis #lung #ILD - Reposted by Broad InstituteFirst stop on our Field Trip tour is Dr. Feng Zhang's lab at the Broad Institute. You may already be familiar with Dr. Zhang’s work if you’ve ever heard of CRISPR… but how do you follow up a hit like that? That’s a story big enough to tell in person. youtu.be/_UimlaolxiA?...
- New study shows a human genetics-to-medicines pipeline that worked in finding new drug candidates for Crohn’s disease. The molecules mimic the effects of a gene variant that protects against chronic inflammation.
- Reposted by Broad InstituteIn 2021 @janewit-thekidgene.bsky.social joined our lab & decided to define the prevalence & clinical correlates of known genetic forms of nephrotic syndrome among an unselected group of adults. 5 yrs later, we're excited to share what he found; a 🧵 kidney-international.org/article/S008...
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- Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.
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- Reposted by Broad InstituteOut today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)
- Study by @ragoninstitute.bsky.social, @mitkochinstitute.bsky.social, @broadinstitute.org team - including @constantine-sci.bsky.social, @drshay.bsky.social, and @shaleklab.bsky.social - suggests a high-fat diet puts liver cells in a state that makes them more susceptible to cancer-causing mutations
- Our immune system declines with age. Now the lab of @zhangf.bsky.social has found a way to overcome this decline by temporarily programming liver cells to improve T cells’ ability to fight infection.
- Broad and @mgbresearch.bsky.social scientists discovered a potential new drug target for Friedreich’s ataxia, a rare but devastating genetic disorder.
- Reposted by Broad InstituteDrs. Matthew Meyerson and Heidi Greulich from the @broadinstitute.org sit down and discuss how they and Bayer scientists developed the first FDA-approved #CancerDrug to come from a Broad scientific discovery. 🤝 Learn more about their academic-industry alliance: bit.ly/4ruQNRl
- Congratulations to the recipients of the 2025 BroadIgnite Awards: Pierre Ankomah, Fabio Cunial, Jordan Doman, Ana Gonzalez Ramos, Sarah Pierce, Avanthi Raghavan, and Jackson Weir! Learn how BroadIgnite helps early-career scientists drive biology forward: broad.io/BI2025.
- LAST CALL! Nominations close Friday, December 5 for the 2026 Merkin Prize in Biomedical Technology 🏆. Nominate: merkinprize.org The 2025 Merkin Prize was awarded to the pioneering scientists behind CAR T-cell therapy. Learn more: youtube.com/watch?v=YM9R... Video credit: HPN Health
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- Nominations are open for the $400,000 Merkin Prize in Biomedical Technology! Do you know a team or individual whose novel device or method has improved diagnosis, treatment, or prevention of human disease? Nominate them today. Deadline: Dec. 5, 2025 merkinprize.org
- Broad scientists Matthew Meyerson and Heidi Greulich discuss the challenges and lessons learned in developing a new lung cancer medicine from Bayer Healthcare Pharmaceuticals that is based on Broad genetic discoveries. @danafarber.bsky.social
- Reposted by Broad InstituteThe @fda.gov approved sevabertinib for HER2-mutant non-small-cell lung cancer, supported by a multi-year research collaboration with colleagues at the @broadinstitute.org. Learn more: bit.ly/49Q2vjd
- The US FDA approved the first cancer drug based on Broad discoveries. Developed by Bayer Healthcare Pharmaceuticals through its research alliance with Broad, this drug is approved for a type of lung cancer that previously had few treatment options. @danafarber.bsky.social
- A team at the Broad Institute co-led by Sarah Pierce, Steven Erwood, and David Liu has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.
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- We're thrilled that Sentinel, a pandemic prevention and response program jointly led by @sabetilab.bsky.social and Christian Happi of the Institute of Genomics and Global Health (IGH), Redeemer’s University in Nigeria, is the Award Recipient for @macfound.org’s #100andChange!
- Join us in Cambridge, MA (or online) on Wednesday, November 19 at 6PM ET for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
- The 2026 Merkin Prize is now accepting nominations! The Prize is a $400,000 award for transformative technologies and pioneering innovators. The Merkin Prize recognizes: 🔹 Real-world impact 🔹 Innovation 🔹 Teams and individuals Nominate by December 5, 2025: merkinprize.org
- On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25
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- Reposted by Broad InstituteWe’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...
- Broad has launched the Biology of Adversity Project, led by @jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
- Broad has launched the Biology of Adversity Project, led by @jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
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- A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.
- Reposted by Broad InstituteExcited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis. www.nature.com/articles/s41...
- Reposted by Broad InstituteRegional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...
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- Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org
- A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.
- Reposted by Broad InstituteWe’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....
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- Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR
- Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.
- Leading epigenetics researcher and longtime Broad member @jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.
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- In her new role as an alliance manager, former drug discovery scientist Gail Guo keeps research projects moving forward for the Broad-Bayer Oncology collaboration. Learn more about her evolving role in a new #WhyIScience Q&A.
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- In a Broad Q&A, Broad scientists Kristin Ardlie and Brad Bernstein talk about AlphaGenome, artificial intelligence, and how foundational datasets like ENCODE and @GTEx are fueling biomedical science in the AI age.
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- Tomorrow, August 14 at 6 PM ET, join us in Cambridge, MA – or tune in online – for a Broad Discovery Series talk with @soumya-boston.bsky.social: "Arthritis, autoimmunity, and how the genome works." Register: broadinstitute.swoogo.com/DiscoverySeries25
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- Next week! Join us on Thursday, August 14 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @soumya-boston.bsky.social, “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySeries25
- New findings show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen.
- Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA, or online, for a Broad Discovery Series talk with @soumya-boston.bsky.social: “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySer...
- Scientists find new factors linked to poor outcomes in the most common lung cancer type cancer, hinting at how certain chemical exposures may contribute to lung cancer risk in people who have never smoked.
- The Omics for Assessing Signatures for Integrated Safety (OASIS) consortium, launched by Broad, @hesiglobal.bsky.social & scientific partners, with @malifesciences.bsky.social support, is sharing data using cell-based omics tools to reduce reliance on animals in drug & agrochemical safety testing.
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- Using an image-based screening method, Broad and Boston University researchers found potential new drug targets for reducing Ebola infection severity, uncovering human genes that, when silenced, impaired Ebola’s ability to replicate. broad.io/Ebola-News-0724
- Partnership between David Liu, @jacksonlab.bsky.social, and rare disease group RARE Hope leads to first use of prime editing for a brain disease that reduced symptoms, extended lifespan in mice, offering hope for other rare genetic diseases. #Science #PrimeEditing
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- We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succeeding Eric Schmidt. We also welcome Aviv Regev as a new member of the Board.
- Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA – or online – for a Broad Discovery Series talk with @soumya-boston.bsky.social : “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySer...
- Reposted by Broad InstituteDr. Ramnik Xavier and Dr. Christopher Smillie from the @broadinstitute.org analyzed individual cells from the intestinal tissue of #Crohns disease patients, measuring gene activity and mapping the cells’ location: bit.ly/4nwuf0s 📃 @natgenet.nature.com: go.nature.com/45UEWDH
- Reposted by Broad InstituteVery excited to share our latest work in @NatureGenet with the Smillie lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation...(cont.) www.nature.com/articles/s41...
- New spatial maps of a key complication of Crohn’s disease reveal the cells and genes involved and lay the foundation for better treatments.
- Gene editing pioneer David Liu discusses baby K.J. Muldoon, the first person treated with a customized gene editing therapy, what made K.J.'s treatment possible, and how on-demand treatments for rare genetic diseases could one day become routine. #GeneEditing #Science
- Being a neuroscientist in a lab focused on protein trafficking in the kidney has given Giulia Monti a unique perspective on Alzheimer’s disease. Learn about the potential paradigm shift she sees in Alzheimer’s disease research in a new #WhyIScience Q&A: broad.io/WISGiulia
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- Reposted by Broad Institute🚨Interested in which genes are the true effectors behind the scenes of the #gwas results? 🚨 This new publication in Nature Genetics, a collaboration between @broadinstitute.org @ebi.embl.org @opentargets.org focuses on approaches to predicted effector gene reporting tinyurl.com/98yxy4hf (1/3) 👇
- Broad and Bayer extend their 10-year cardiovascular research collaboration by 5 more years, with aims to identify joint precision cardiology targets, leverage the established human cardiomyocyte platform, and discover novel therapeutic approaches. www.broadinstitute.org/node/5558906
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- A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social
- A new pipeline could help scientists discover unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. broad.io/CITADel-news @mit.edu @tuftsmedschool.bsky.social
- Researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia.
- Reposted by Broad InstituteThis collection describes a range of methods allowing access to neuronal and non-neuronal cell types, opening the door to targeting the nervous system in ways that were previously unimaginable 🧠 Check out our BRAIN Armamentarium Consortium🧵 www.cell.com/consortium/b...
- Reposted by Broad Institute🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...
- Reposted by Broad InstituteI am deeply honored and humbled to have received the 2025 Merkin Prize in Biomedical Technology along with my long term mentor and colleague Carl June, and Isabelle Rivière, and Michel Sadelain, w/ collaborative work of many scientists, clinicians, & patients. www.broadinstitute.org/news/2025-me...
- Carl June (@upenn.edu), Bruce Levine (Penn), Isabelle Rivière (Takeda), Michel Sadelain (@columbiauniversity.bsky.social) have been awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing CAR T-cell therapy for cancer.
- A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. @mgbresearch.bsky.social @targetcancer.bsky.social
- Eating disorders run in families and have a strong heritable component, especially anorexia nervosa, but the genetics underlying these conditions are not fully understood. A new direct-to-patient effort could help scientists develop better diagnostics & treatments. @hsph.harvard.edu
- We’re thrilled that base editing, developed by researchers in the lab of Broad member David Liu, is having such a profound impact in the clinic. Congratulations to former Broad postdoc @kiranmusunuru.bsky.social & @childrensphila.bsky.social on their groundbreaking work. www.nejm.org/doi/full/10....
