Michael Honigberg
Cardiologist and researcher at Mass General / Broad Institute / Harvard Med. Preventive cardiology, women’s health, genomics. honigberglab.mgh.harvard.edu
- 📣 We’re hiring! My team at Mass General Brigham / @broadinstitute.org is growing: • Postdoc (PhD; human 🧬 & multi-omics) • Research fellow (clinical trials & epi; 2-yr) • Computational associate Join a collaborative, high-impact 🫀 precision medicine team. DM or email mhonigberg@mgb.org
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- The lab's first sim pub of #ESC2025 is now online in @jaccjournals.bsky.social #JACC! jacc.org/doi/10.1016/... Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study 👇 (1/X)
- (2/X) CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers We + others have shown that CHIP also associates w/ ⬆️ CVD risk But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
- Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs Honigberg lab is rapidly growing 📈 👇 @mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
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- The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes journals.lww.com/greenjournal...
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- Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
- Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
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- Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP) overall and across levels of HDP genetic risk www.jacc.org/doi/10.1016/... #CardioObstetrics #CardioSky
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- Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social www.nature.com/articles/s41... Full text link: rdcu.be/ef9VW @mgbresearch.bsky.social @mgbwomenheart.bsky.social
- Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social professional.heart.org/en/education...
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- Important trial of CAC scoring-guided CVD prevention (CAUGHT-CAD) out in @jama.com today: jamanetwork.com/journals/jam... In Australians w/ intermediate CVD risk (+ FHx) w/o clear statin indication, CAC score-guided prevention yielded reduced progression of total and non-calcified plaque over 3 y
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- Reposted by Michael HonigbergGuardian story about Federal Register issue is up. www.theguardian.com/us-news/2025...
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- The White House has ground NIH operations to a halt. E.g., the NHLBI’s CCHS study section, which evaluates large patient-oriented cardiovascular research proposals, was cancelled at the last minute this week. This is bad for science, scientists, patients/the public, and the economy.
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- Great in-depth review in this year's @ahajournals.bsky.social #Circulation Go Red for Women 💃 issue on HTN during & after 🤰 from the @accintouch.bsky.social CVD in Women Committee & Cardio-OB/Repro Health Section led by Malamo Countouris and Zainab Mahmoud 👇 www.ahajournals.org/doi/full/10....
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- Reposted by Michael HonigbergEast & South Asian-Specific BP Trajectories & CVD #CardioSky #cvPrev #Hypertension www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @pnatarajanmd.bsky.social @mchonig.bsky.social @romitb.bsky.social @somijemmacho.bsky.social @psatishmd.bsky.social @drmonalidesai.bsky.social
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- In our latest led by Maria Pabon (MGB/BWH) now in Circ Res, we sequenced RNA from venous endothelial cells from 🤰 w/ or w/o preeclampsia We 👀 evidence that an aminopeptidase, METAP1, drives EC dysfunction in preeclampsia www.ahajournals.org/doi/10.1161/... #CardioObstetrics @mghcvrc.bsky.social
- Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social
- Reposted by Michael HonigbergHUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!! Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
- So so incredibly proud of 🇧🇪’s finest @artschuermans.bsky.social for this incredibly well-deserved recognition as the @ukbiobank.bsky.social Early Career Researcher of the Year for 2024! ⭐️ Lots of high-impact work so quickly - and lots more to come CC @broadinstitute.org @pnatarajanmd.bsky.social
- Reposted by Michael HonigbergVery nice summary of our study led by @artschuermans.bsky.social A. Pournamdari & with @mchonig.bsky.social www.massgeneralbrigham.org/en/about/new... @mgbresearch.bsky.social
- What does the circulating proteome teach us about common heart diseases? Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions. Mentored (supremely) by @mchonig.bsky.social and @pnatarajanmd.bsky.social nature.com/articles/s44... (1/x)
- Reposted by Michael HonigbergNew paper out in @ScienceMagazine! In 8 studies (multiple platforms, methods, time periods) we find: misinformation evokes more outrage than trustworthy news, when it does it's shared more + ppl are less likely to read before sharing. w/ @killianmcl1 @Klonick @mollycrockett 🧵👇
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- Excited to share our latest in Nature Cardiovascular Research led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky Open access paper here: www.nature.com/articles/s44... Great thread from Art below 👇
- What does the circulating proteome teach us about common heart diseases? Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions. Mentored (supremely) by @mchonig.bsky.social and @pnatarajanmd.bsky.social nature.com/articles/s44... (1/x)
- Reposted by Michael HonigbergWhat does the circulating proteome teach us about common heart diseases? Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions. Mentored (supremely) by @mchonig.bsky.social and @pnatarajanmd.bsky.social nature.com/articles/s44... (1/x)
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- Maria Pabon of BWH cardiology presenting her work on biomarkers in 🤰 and postpartum cardiometabolic trajectories at #AHA24 #cardioobstetrics #cardiosky #medsky
- Fantastic thought provoking cardiometabolic and 🫀 prevention research at this morning’s featured oral abstract session #AHA24 @ahascience.bsky.social #CardioSky #MedSky
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- Great YIA presentation by ⭐️ Kelvin Supriami at #AHA24 of our data integrating @MGHHeartHealth cor angio data + Lp(a) Very ⬆️ Lp(a) (>=175 nmol/L) associated w/ repeat angiography, ISR, revasc, & mortality after cath, + need for PCI after CABG, indept of baseline athero burden #CardioSky #MedSky
- SUMMIT @ #AHA24 N=731 w/ obesity + HFpEF (EF >=50%) + enrichment factors randomized to tirzepatide vs placebo, >50% 🙋♀️!, most w/ low BNP, med f/u 104 wks Co-PEP: (1) worsening HF or CV 💀 (2) KCCQ Tirzepatide ➡️ HR 0.62 for worsening HF/CV 💀, driven by worsening HF www.nejm.org/doi/full/10....
- BPROAD at #AHA24 sim pub in NEJM N=12,821 Chinese adults >=50 y with T2D randomized to 🎯 SBP <140 vs <120 mmHg, 45% 🙋♀️, median 4.2 y f/u PEP: composite MI, CVA, HF, CV death Intensive BP control ➡️ HR 0.79 (95%CI 0.69-0.90) Results differ from those of ACCORD (2010) www.nejm.org/doi/full/10....
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