Pradeep Natarajan
Cardiologist, genetics researcher.
Massachusetts General Hospital | Harvard Medical School | Broad Institute of Harvard & MIT
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- Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @broadinstitute.org @mgbresearch.bsky.social
- New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com My comments in @nytimes.com nytimes.com/2025/07/21/h...
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- Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
- An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
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- Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score www.ahajournals.org/doi/10.1161/...
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- Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
- Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
- Reposted by Pradeep Natarajan📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this
- Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy. Register us02web.zoom.us/meeting/regi... @drmarthagulati.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social .
- Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
- A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
- The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS... @mgbresearch.bsky.social @harvardmed.bsky.social
- End of an era icelandmonitor.mbl.is/news/news/20...
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- Reposted by Pradeep NatarajanOut today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!
- 📣New from @hilarycmartin.bsky.social & co! 📄Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity
- The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social Please sign up and share! ourhealthstudy.org @romitb.bsky.social
- Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv
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- Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
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- Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
- Interact with all of the results in the Pleiotropy Atlas (PLATLAS)! platlas.cels.anl.gov
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- Reposted by Pradeep NatarajanInterested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥 We're hiring graduating seniors who are seeking ~2 years of post-bac research experience. If you're interested in gaining experience in next gen medicines, please reach out and apply! Link 👇
- Delighted to share our American Heart Association Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
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- Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w A. Patel demonstrates how successive integration of scores can improve accuracy & stability www.nature.com/articles/s41... @naturecomms.bsky.social
- So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social
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- Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social
- Reposted by Pradeep NatarajanFantastic Cardiology Grand Rounds on advances in polygenic risk scores from field leader Pradeep Natarajan @pnatarajanmd.bsky.social, introduced by our own Hattie Chung @hattaca.bsky.social
- Punxsutawney Phil is only 35% accurate(!) but Staten Island Chuck is 85% accurate www.noaa.gov/heritage/sto... Unlike Punxsutawney Phil, Staten Island Chuck predicts *early* Spring www.cbsnews.com/newyork/news... #GroundhogDay
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- Delighted to share our study by S. Urbut with A. Fahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events www.ahajournals.org/doi/10.1161/... @broadinstitute.org @mgbresearch.bsky.social
- Reposted by Pradeep Natarajan🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal, 👉 gvascstudy.org 👈
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- Essay emphasizes the need for food and nutrition policies that make it easier for people to purchase & consume a healthier diet www.nytimes.com/2024/12/16/o... @nytimes.com
- Genotype-first identification of Wilson’s Disease in the Estonian Biobank. 17 identified and only 8 previously diagnosed. Very high prevalence of neurodegenerative symptoms for those with WD genotypes www.nature.com/articles/s41...
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- Good opportunity for improved clinical decision support to enhance alignment between doctors and insurers to avoid exhausting back-and-forth www.statnews.com/2024/12/12/a... @statnews.bsky.social
- Very nice viewpoint from @dranulala.bsky.social who walks the walk www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social #JACCAdv
- Topline of ph3 BROADWAY exploratory 1y analysis: Among those with ASCVD or HeFH with insufficient LDL-C-lowering, oral obicetrapib (CETPi) v placebo ↓ LDL-C 33%, ↓MACE 21%, ↓coronary heart death 20%, ↓all-cause mortality 17%. ir.newamsterdampharma.com/news-release... [1/2]
- Polygenic predisposition to prolonged QTc among individuals with a normal baseline QTc predicted those having QTc prolongation after sotalol 80mg www.ahajournals.org/doi/abs/10.1... @ahajournals.bsky.social
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- Reposted by Pradeep Natarajan👀🎉 Check out our new PRIMED (Polygenic Risk Methods in Diverse Populations) Consortium starter pack! go.bsky.app/RFJRsTt
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- HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!! Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
- US Senate poised to vote on the bipartisan HEARTS Act aimed to ensure school preparedness for cardiac arrest newsroom.heart.org/news/u-s-sen... @ahascience.bsky.social
- Google's new quantum computer reportedly can compute a mathematical task that the world's current top supercomputer could not complete in 10 septillion years (exceeds the age of the universe) www.nytimes.com/2024/12/09/t... @nytimes.com
- Intriguing but very small numbers - potentially high risk for diabetes for those with HFE C282Y homozygotes (genotype for hereditary hemochromatosis) but with normal ferritin or transferrin saturation. Oddly no signal when these are high. www.bmj.com/content/387/... @bmj.com
- Among mice continuously administered AngII/Epi, a fibroblast activation protein (FAP) vaccine mitigated cardiac fibrosis www.ahajournals.org/doi/epdf/10....
- The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway). New study shows even greater (10% ↓odds) for AAA. www.ahajournals.org/doi/full/10....
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- Among pregnant/postpartum persons who received unusual/unreportable cfDNA for fetal aneuploidy, 1 in 2 had occult cancer! Most variants were CNVs across multiple chromosomes www.nejm.org/doi/full/10....
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- Reposted by Pradeep NatarajanApplications are now OPEN for the 2025 Human Genetics and Genomics GRC and GRS!! 🎉 🧬 📅 GRS: July 5-6, 2025 📅 GRC: July 6-11, 2025 📍 Portland, Maine @calliao.bsky.social and I are co-chairs for the GRS, with Shamil Sunyaev and @eimearekenny.bsky.social as the GRC chairs 👀 Links to apply below 👇
- Topline of SURMOUNT-5: ph3b open-label among adults with overweight/obesity + related conditions & w/o T2D, Zepbound (tirzepatide) led to 47% relative greater weight loss than Wegovy (semaglutide) - 20.2% (50.3lb) v 13.7% (33.1lb) over 72w investor.lilly.com/news-release...
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- Reposted by Pradeep NatarajanWelcome to my new Bluesky account! 🌟 We’re dedicated to unlocking the mysteries of kidney disease using cutting-edge science. Join us on a journey of discovery as we share what we do, how we do it, and the resources available at susztaklab.com! 🧵👇
- Reposted by Pradeep NatarajanStanford Hematology is recruiting a physician-scientist in heme malignancies, details below, pls share, pls reach out with Qs, I’m excited to grow our amazing Division! @stanforddeptmed.bsky.social
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- Reposted by Pradeep NatarajanThis is really horrific. These single cell reference atlases are widely used as is to train all kinds of models! This is one of the reasons I've constantly harping about uniform reprocessing & extremely careful QC of large atlases. 1/
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- Join us Dec 17 7p EST for a free webinar by me on 'Tips for Preventing Heart Disease' from @americanheart.bsky.social MA moderated by A. Bhatt register: heart.zoom.us/webinar/regi... series: www.heart.org/en/affiliate...
- On #GivingTuesday2024, consider supporting our efforts to discover and understand reasons why heart disease and diabetes are common among South Asian individuals 💜 ourhealthstudy.org 🙏 because.massgeneral.org/campaign/our...
- Fantastic to see the state of California commit $9.25M over 4y to extend All of Us' engagement efforts throughout California allofus.nih.gov/news-events/...
- Very nice summary of our study led by @artschuermans.bsky.social A. Pournamdari & with @mchonig.bsky.social www.massgeneralbrigham.org/en/about/new... @mgbresearch.bsky.social
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- Great collaborative work spearheaded by M. Ardissino showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
- Our review led by @jsdron.bsky.social of the contributions of the Global Lipids Genetics Consortium (www.lipidgenetics.org) journals.lww.com/co-lipidolog...
