Ben Kleinstiver
Associate Professor @ Mass General Hospital & Harvard Medical School
Genome editing / Protein eng. / Molecular medicine 🇨🇦🧬
Kayden-Lambert MGH Research Scholar '23-28
- An inspirational panel this morning with none other than baby KJ himself - highlighting the stories of heroes @ahrensnicklas.bsky.social & @kiranmusunuru.bsky.social ( hosted by @jasonmast.bsky.social). Crescendo: KJ's Dad on watching 🏈 with his son: "This is what we thought we would never get". ❤️👏
- Congrats to @connorjtou.bsky.social on being named a 2025 #STATWunderkind. His enthusiasm in the lab is contagious and he thrives on doing really hard things. Really well deserved recognition for an innovator and emerging leader in our field! 👏 🙌 @mgbresearch.bsky.social @harvardmed.bsky.social
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- Optimization of a bespoke base editor to treat a severe pediatric vascular disease! 🫀🧬 Our manuscript describes: 1️⃣ Engineering a target-specific BE🧬 2⃣ A *must avoid* bystander edit that occurs with WT SpCas9 BEs! 🙅♂️ 3⃣ Extension of lifespan after in vivo editing! 🐁✅ www.nature.com/articles/s41...
- Reposted by Ben KleinstiverExciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...
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- Less than one day to celebrate a major win for science, before returning to our regularly scheduled programming of destruction of the American scientific enterprise and capitulation..
- Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org
- Reposted by Ben Kleinstiver1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
- Reposted by Ben KleinstiverGenomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new work @arcinstitute.org, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
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- An incredible collaborative effort led by @kiranmusunuru.bsky.social @ahrensnicklas.bsky.social @urnov.bsky.social & others. Congratulations to @rachelsilverstein9.bsky.social who designed the Cas9 enzyme that went into this drug. Wishing K.J. & his family all the best 🙏
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- Reposted by Ben KleinstiverYesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
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- In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...
- Major kudos to Cas9 engineer extraoirdinare @rachelsilverstein9.bsky.social who bravely led this project from her Harvard BBS Program rotation until now. A massive collaborative effort including contributions from Nahye Kim @ann-sophiekroell.bsky.social @russelltwalton.bsky.social & many others.
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- Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥 We're hiring graduating seniors who are seeking ~2 years of post-bac research experience. If you're interested in gaining experience in next gen medicines, please reach out and apply! Link 👇
- Reposted by Ben KleinstiverBluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
- If you're unsure whether advocacy or protest to save life-saving research matters, an important message here starting at 33:00. Together we can prevent devastating healthcare & economic impacts, and save science that doesn't see red or blue.. We need your support! ✊🧬🔬🧑🔬 youtu.be/cw0F8G4-dMw?...
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