Vanderbilt Center for Structural Biology
Vanderbilt Center for Structural Biology - Research dedicated to determining the 3D structure of biological macromolecules at or near atomic resolution.
www.vanderbilt.edu/csb
- 🚨Preprint alert! The @stephanieaw.bsky.social lab shows that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! @vubasicsciences.bsky.social www.biorxiv.org/content/10.6...
- Reposted by Vanderbilt Center for Structural BiologyWe are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!
- While everything feels flash-frozen in Michigan, it's a great time to plan for U-M's 2026 #CryoET Data Processing Workshop! This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data. Apply by March 20: myumi.ch/lsi-cryo-wor...
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- New #research led by the Georgiev lab shows how #AI and #protein language can speed antibody design to thwart novel viruses! Read more about this study: news.vumc.org/2025/11/04/a...
- New work from the Sanders Lab: Pharmacological tools to modulate ordered membrane domains and order-dependent protein function. @kmstefanski.bsky.social @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social
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- Reposted by Vanderbilt Center for Structural BiologyInternship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!
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- Pre-print alert! 🚨 Work from the Chuck Sanders lab and collaborators with first author @kmstefanski.bsky.social. "Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function" www.biorxiv.org/content/10.1... #research #biophysics #protein
- Reposted by Vanderbilt Center for Structural BiologyNew preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...
- Kate Clowes Moster, of the Chuck Sanders lab, is the winner of the 2026 Dr. Anne Karpay Award in Structural Biology! bit.ly/2026-karpay @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social @vandybiomed.bsky.social
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- Congrats to @bpbrown.bsky.social on his single-author paper recently published in @pnas.org! Read more on how he tackles a key roadblock for AI in drug discovery medschool.vanderbilt.edu/basic-scienc... @vubasicsciences.bsky.social
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- Reposted by Vanderbilt Center for Structural Biology¡No olviden solicitar a nuestro premio de viaje para asistir a la conferencia @biophysicalsoc.bsky.social #BPS2026! Vean más detalles de cómo solicitar en el fondo 👇 --- Don't forget to apply to our travel award to attend the #BPS2026 Meeting! See application instructions below 👇
- 🚨🚨🚨ANUNCIO IMPORTANTE 🚨🚨🚨 ¡Tenemos un premio de viaje para asistir a #BPS2026 @biophysicalsoc.bsky.social en San Francisco! Sigue estos pasos: ➡️ Solicita al BPS Travel Award (www.biophysics.org/2026meeting/...) ➡️ Marca la opción para ser considerado para el premio de SoBLa ¡Solicita hoy! ✅
- With a new collaboration called diffUSE, the @stephanieaw.bsky.social lab is helping to advance our understanding of protein motion, leading to a new paradigm in dynamic structural biology. @vubasicsciences.bsky.social medschool.vanderbilt.edu/basic-scienc...
- Congratulations to @dougkojetin.bsky.social!
- Reposted by Vanderbilt Center for Structural BiologyWe thank our sponsor #Pfizer for this amazing opportunity! 🤩🤩🤩
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- Recent computational work on cold-active bidomain cellulase from the @mutexazjy.bsky.social lab published in Protein Science: "Linker‐mediated domain separation enhances cold adaptation in cellulases" @vuartsci.bsky.social @vanderbiltvicb.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
- Cool news from the @stephanieaw.bsky.social lab!
- 🎊Congratulations to CSB researcher Yi Ren on her promotion to Associate Professor of Biochemistry! 🥂
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- It's just around the corner! Register now: medschool.vanderbilt.edu/vicb/2025-st...
- Reposted by Vanderbilt Center for Structural BiologyDeadline extended! Submit your images to the Second Annual CISR Life is Beautiful Image Contest! New deadline is July 18. Open to anyone with CISR-acquired images. More details here. medschool.vanderbilt.edu/basic-scienc...
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- New work from Yang Lab, Link Lab and Yi-Lei Zhao takes a first step toward structural prediction of RiPPs: lasso peptide. nature.com/articles/s41... Access the tool here: lassopred.accre.vanderbilt.edu @vanderbiltvicb.bsky.social
- New findings from the @chazinwalter.bsky.social lab & collaborators suggest that combining 5hmC with olaparib can restore the sensitivity of chemoresistant BRCA1/2-deficient cells. 🎉Congrats to 1st author Suhas Kharat! @vubasicsciences.bsky.social doi.org/10.1016/j.jb...
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- The external speakers are set and ready to navigate the intersection of #AI & #StructBio for the Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology. 🗓️Tuesday & Wednesday, March 17–18, 2026 🏫Campus of Vanderbilt University bit.ly/4ldBOaz
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- New research from the Plate and Meiler labs offers promise for treatment-resistant cystic fibrosis patients. 1st author Eli McDonald has personal reasons for the research. Read more ... medschool.vanderbilt.edu/basic-scienc... @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social
- Meet @prash-singh.bsky.social of the Iverson lab. He’s getting used to the spotlight from his recent @smartereveryday.bsky.social appearance. He’s still the down-to-earth Prash who is always ready to respond to the “call of duty." bit.ly/prash2025 @vubasicsciences.bsky.social #cryoem #research
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- Mark your calendar and spread the word ... @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social @vucellimaging.bsky.social @vandybiomed.bsky.social #structuralbiology #AI #research #cryoem #cryoet #protein
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- Dr. Rong Sun and members of the Qiangjun Zhou lab are redefining synaptic architecture using nanoblocks as key organizing units in the postsynaptic density. Read more ... bit.ly/4jTKTFg @vubasicsciences.bsky.social
- Reposted by Vanderbilt Center for Structural BiologyJoin us for the exciting Cell Dynamics Symposium at Vanderbilt! Poster deadline coming up May 12th. Everyone welcome - please repost!
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- Sanders lab Postdoc @drstefanski.bsky.social lab motto might be “a place for everything and everything in its place.” Outside the lab she likes to wreak a bit of havoc in Smashville! That is, when it doesn’t get in the way of a good book. Meet Katherine…@vubasicsciences.bsky.social bit.ly/42yJzRY
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- Enzyme engineering is entering a new era characterized by the integration of computational strategies. The John Yang lab shows how physics-based modeling will help the field of computational enzyme engineering reach its full potential. Read more ... www.nature.com/articles/s43...
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- Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu
- ⚓️ Celebrate #GivingDay by designating your gift to "The Karpay Award in Structural Biology" and/or "Center for Structural Biology" 🔬🧪 give.vanderbilt.edu/giving-day-2... Who is Dr. Anne Karpay? vanderbilt.edu/csb/karpay-awa
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- ⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬 Give to the CSB: www.givecampus.com/campaigns/57... Give to the Karpay Award: www.givecampus.com/campaigns/57...
- Have you read the new paper from the QiangjunZhou lab? They show that the postsynaptic density in excitatory synapses is organized into heterogeneous nanoblocks, revealing a new layer of synaptic complexity. doi.org/10.1083/jcb.20 #cryoEM #biophysics #neuroscience @vubasicsciences.bsky.social
- Check out @stephanieaw.bsky.social insights in this @nature.com article on the AI-powered drug discovery ...
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- 🚨Preprint alert! The Mchouarab Lab & collaborators use #cryoEM & MD simulations to find out how an ABC multidrug exporter releases it substrate. www.biorxiv.org/content/10.1... @vubasicsciences.bsky.social
- Meet Areetha D'Souza ... vanderbilt.edu/csb/2025/03/...
- "How do we foster excitement in the structural sciences in our students and develop our own approach to mentorship?" This article is a good place to start! pubs.aip.org/aca/sdy/arti... #structuralscience #proteinscience #biochemistry
- 💊 CSB researchers @dougkojetin.bsky.social and John Yang find how small changes in drug molecules can switch PPARγ, a key protein, between active and repressive states. The breakthrough could help design better treatments for metabolic diseases. #NMR #crystallography bit.ly/41Gktif
- CSB Spotlight: X-ray #Crystallography - Paving the way for ‘hypoallergen’ treatments against peanut allergies. Ben Spiller & collaborators recent work show how IgE antibodies’ structural, immunological & functional properties interact with peanut allergens. bit.ly/3Xw1mWO
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- New collaboration from @vubasicsciences.bsky.social and Northwestern University discover new mechanisms that cause irregular heartbeat. 🎉Congrats to 1st author Kathryn Brewer Butcher!! 🎉 Spotlight: bit.ly/4hYxIBC Full paper published in PNAS: pnas.org/doi/10.1073/...
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- New work from the @lpjacksonlab.bsky.social uses a combination of biochemical, biophysical and computational modeling techniques to investigate endosomal trafficking players. Congrats to 1st author @mintuju.bsky.social! bit.ly/4hYry4o @vubasicsciences.bsky.social @vandybiomed.bsky.social
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