Doug Kojetin
Structural biology, biophysics, biochemistry, molecular and cellular pharmacology | nuclear receptors | NMR | Vanderbilt University, Department of Biochemistry | kojetinlab.org
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- Reposted by Doug KojetinIntroducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯 When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep) #sfn2025 #sfn25
- Happy to serve! 🧲 #NMR
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- Reposted by Doug KojetinToday #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants. We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15. Even if this ends up being temporary, it’s time we don’t have.
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- Reposted by Doug KojetinHere @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu
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- Reposted by Doug KojetinBudget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
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- Reposted by Doug KojetinTV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2
- Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/
- Reposted by Doug KojetinNext Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!
- Reposted by Doug KojetinSome new language appeared in the HHS Grants Policy Statement last week. It doesn't apply to NIH grants (yet) 1/n
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- Reposted by Doug KojetinCongrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."
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- Reposted by Doug Kojetin⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬 Give to the CSB: www.givecampus.com/campaigns/57... Give to the Karpay Award: www.givecampus.com/campaigns/57...
- Reposted by Doug KojetinGroundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
- Sunday morning elliptical workout entertainment thanks to @stephanieaw.bsky.social @fraserlab.bsky.social
- Reposted by Doug KojetinWe are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
- Fast, fair, and PAID peer review! WTG @danielgorelick.bsky.social 🙌
- …and treatments for bladder cancer!
- 💊 CSB researchers @dougkojetin.bsky.social and John Yang find how small changes in drug molecules can switch PPARγ, a key protein, between active and repressive states. The breakthrough could help design better treatments for metabolic diseases. #NMR #crystallography bit.ly/41Gktif
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- Now published! Read our newest story! doi.org/10.1038/s414...
- Reposted by Doug KojetinATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...
- Reposted by Doug KojetinI maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!
- Reposted by Doug Kojetin😳🤯. Dr. Laurer was the coauthor of the memo yesterday acknowledging that the NIH funding freeze was illegal and directing staff to resume issuing grants.
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- Reposted by Doug KojetinThis is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...
- Application deadline extended to Feb 14, 2025! Do you know any undergraduate students interested in structural biology? Check out this summer program at Meharry Medical College in Nashville TN!
- Reposted by Doug KojetinTrainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify
- Reposted by Doug KojetinCool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...
- Reposted by Doug KojetinIt’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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- Reposted by Doug KojetinOn changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
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- Reposted by Doug KojetinPREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
- CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays biorxiv.org/content/10.1101/202…
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- Reposted by Doug KojetinExtremely disappointed to see HHMI decide to kill their Inclusive Excellence program, including terminating the current IE3 awards to over a hundred institutions effective this year in the middle of a 6-year grant. I was hoping HHMI (and other private funders) would continue to lead the way.
- Reposted by Doug KojetinHere’s why we need to study & fund developmental biology: to understand, prevent & treat birth defects. Infants can’t speak, so we must be their advocates
- Birth defects are the #1 cause of death in the first year of life (🧵). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5 wisqars.cdc.gov/pdfs/leading...
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- So awesome that Mitch Lazar is visiting Vanderbilt as part of our Apex Lecture Series (scientists who are influencing the trajectory of their fields) to talk about REV-ERB #nuclearreceptors !
- Reposted by Doug KojetinI’m putting together a post on what’s going on in the trenches in various parts of the NIH. Anyone who would like to share experiences (anonymously!) can reach me at Dblowe.18 on Signal
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- In The Pipeline blog featuring estrogen receptor papers with contributions from @nrimpact.bsky.social members @docfanning.bsky.social and @nelsonlab.bsky.social #nuclearreceptors
- Reposted by Doug KojetinMore from inside NIH: Per a source with knowledge, for all internal research (of which there is like $10 billion worth or so), ALL purchasing shut down as of yesterday. That means gloves, reagents, anything involved with lab work, which means a lot of that work will stop.
