Patrick Murphy
Associate Professor @Cornell #Genetics #Epigenetics #Chromatin #Zebrafish #Development #Reproduction #EvoDevo #Bioinformatics #ZGA #StemCells #Regeneration #GoBills #BillsMafia
blogs.cornell.edu/murphylab/
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- Reposted by Patrick MurphyI cannot emphasize this enough, if you're cold-emailing me applying to my lab I would so much rather get the bulleted broken list of genuine interests than whatever letter ChatGPT spits out in its stead If you're training with me, I'm working with you not an LLM. I want to see who you are!
- Reposted by Patrick MurphyGreat advice received as a postdoc: Do the easiest thing. I was 3 years into my postdoc and juggling projects w/nothing concrete = career crisis I went to my advisor Paul Sternberg for help. He asked what was going on & what mutant had the strongest phenotype. "Clone the easiest one." It worked.
- Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...
- Fire Ring Danio
- Reposted by Patrick MurphySo excited to finally share my recent work on sex differences in crossing over using mice from diverse genetic backgrounds! www.biorxiv.org/content/10.6...
- Reposted by Patrick MurphyAbsolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
- Maybe I should teach this and an alternative “modern” perhaps even “Gen Z” definition of epigenetics next semester.
- Reposted by Patrick MurphyA tiny trial in New York has shown that personalized mRNA vaccines can provoke massive, lasting immune responses against pancreatic cancer, even as sweeping federal cuts now threaten the fragile labs required to produce them. theintellectualistofficial.substack.com/p/a-breakthr...
- I still receive email inquires about postdoc jobs in my lab, with generic cover letters from applicants who don’t seem to be genuinely interested in our research… please save everyone time and read this article before emailing PIs: network.febs.org/posts/consid...
- Any recommendations on getting a journal editor to respond to an email? Desk rejection is taking longer than peer review these days, and I don’t seem to get any response emails back from editors.
- Reposted by Patrick MurphyExcited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...
- After my first semester teaching Genetics to 250+ Cornell undergrads, I’m surprised to find that the classroom has become my happy/safe space…
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- Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
- Check it out: New tech can unlock mysteries of genome’s hidden half news.cornell.edu/stories/2025...
- Imagine thinking you’re the smartest person in a room full of brilliant scientists. This is the confidence/ignorance of anti-vaxxers, empowered by their leader RFKjr.
- Soliciting recommendations for 3D printers and lab supply blue prints. Please share and RT.
- Reposted by Patrick MurphyTE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
- Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...
- New lab photo, featuring chromatin!
- Something to add to my reading list. www.biorxiv.org/content/10.1...
- If you want to be truly inspired, take some time and read the beautiful mechanisms described in one of Steve’s discussion sections. He’s a master, a technician, and an artists all wrapped into one. One of my idols.
- Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. www.brandeis.edu/rosenstiel/r... (Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
- It’s like nails on a chalkboard everytime I hear a scientist pronounce nuclear as ‘nuc-you-lar’ instead of ‘new-clear’ or when I hear ‘A-tack-seq’ instead of ‘attack-seq’… arrgghhh
- New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!! CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
- The frig in my basement has a magic gene editing drawer.
- Big day for the new Cornell version of the Murph lab. Our first gel… woohooo!!!! Science Baby!!!
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- The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis - Journal of Biological Chemistry www.jbc.org/article/S002...
- Check out the new chalk art outside the lab at Cornell!
- Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
- TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...
- Congrats Shan. It was wonderful to participate in the graduation ceremony with you! @urochester.bsky.social
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- Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.
- Congrats!!
- 🎉Congratulations to our @idajentoft.bsky.social, postdoc in the @pauligroup.bsky.social on being awarded a HFSP fellowship! The funding will support her research into the molecular mechanisms that regulate translation during embryonic diapause. More about the project: www.imp.ac.at/news/article...
- Having an awesome time at the Tri-Repro meeting @pennmedicine.bsky.social @pennepigenetics.bsky.social with my good bud @themodzlab.bsky.social
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- Had a wonderful time visiting the Genetics Department at the University of Georgia. Great food! Great conversation! Great company! and Excellent weather! Thanks for the invite @gollmg.bsky.social
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- Congrats Brandon! So proud of your accomplishments.
- We all know the story of Henrietta Lacks, but there are countless other examples when biomedical research advanced with a little regard for morals or ethics - often at the expense of poor, disadvantaged, or minority individuals. This book has been enlightening. A good read for current scientists.
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- PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
- ... Brandon, as shared student between my lab and @mitchelloconnell.bsky.social, has identified major biases in ChIP-Seq datasets, which prohibit the study of heterochromatic loci and repetitive elements in several mammalian cell types... 2/n
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- Reposted by Patrick MurphyWe did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...
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- WTF!!! This is a for real disaster!! He needs to be stopped. We can’t have this anti-science lunatic leading HHS.
- 🤦♂️ shit.
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- ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer www.biorxiv.org/content/10.1...
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- This is great news from one of my favorite trees - that was nearing extinction. Breeding programs established variably resistant backgrounds in which resistance-associated alleles could be identified, using next gen strategies. Putative targets for future engineering.
- Bud stage? #Zebrafish
- Reposted by Patrick MurphyHere is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine. @socdevbio.bsky.social
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- Of course, RFK is part of the long standing attack on medicine by pseudo scientists and snake oil salesman.
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- Reposted by Patrick MurphyReminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
- Reposted by Patrick MurphyDisruptions to the NIH impact more than just science; they will hit all Americans in our wallets. I spoke yesterday with Becky Fogel from @kutnews.bsky.social about the important role NIH-funded research plays in the economy. 🧵 1/n www.kut.org/education/20...
