Simon Cleary
Research group leader and lecturer in pharmacology at King's College London: kcl.ac.uk/people/simon-cleary
Studying lung immunology with new imaging techniques to enable improvements in respiratory medicine.
- Reposted by Simon ClearyToo much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...
- Useful article addressing an often-overlooked way in which research impacts the environment:
- 'This initiative encourages staff to delete unnecessary data and improve data management, thereby lowering the environmental impact of data storage. We present a roadmap with 11 quick tips (Fig 1) for organizing a data cleaning challenge within any organization.' journals.plos.org/ploscompbiol...
- Reposted by Simon ClearyGood news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...
- Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!
- Excited to share our new work on the role of CD39 polymorphism in promoting in situ pulmonary thrombosis in Sickle Cell Disease. Thanks all mentees and collaborators. @versitiresearch.bsky.social www.nature.com/articles/s41...
- Reposted by Simon Cleary"Does this handle survival plots too?" asked @load-dependent.bsky.social Yes it does! See below for RECOVERY. Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).
- Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
- Reposted by Simon ClearyTumor-draining Lymph nodes - Online event next week! follow the link to register On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer: events.cancer.gov/dcb/tdln #TLDNForums
- Reposted by Simon ClearyAbsolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
- Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response. www.crick.ac.uk/news/2025-12...
- This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods
- Reposted by Simon ClearyPlease check out our job post @biologists.bsky.social! We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens! bit.ly/3La9idq
- Enjoyed learning about the importance of Batf3 for IL-17-producing γδ T cell responses that protect neonates during influenza infection! Congrats Pedro and colleagues!
- Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...
- Reposted by Simon ClearyAre you an emerging clinical academic leader in respiratory medicine? Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career! Get in touch if you’d like to discuss. www.cam.ac.uk/jobs/assista...
- Fun revisiting this study and looking at the eLife peer review system for this postLight:
- Insightful ‘postLight’ just uploaded by @simoncleary.bsky.social 👀 Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @elife.bsky.social #postLight: prelights.biologists.com/highlights/m...
- Love these 3D renderings of the extracellular matrix cages surrounding megakaryocytes! bsky.app/profile/wcla...
- Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!
- 🔬 Is seeing believing? Discover how cutting-edge imaging and multi-omics are transforming our understanding of immune cell interactions and spatial immunobiology. Don’t miss this parallel session at #BSI25! Secure your place: bit.ly/3IkxWq8
- Reposted by Simon ClearyOutstanding PhD fellowship call OPEN for excellent students. lacaixafoundation.org/en/doctoral-... This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels). If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
- Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week! Great line-up of speakers. Send an email if you would like to meet at or around the conference.
- Reposted by Simon ClearyWe are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP. www.kcl.ac.uk/jobs/131447-...
- 'B' frequently happens and would grind my gears if it weren't so funny.
- Great to hear good news on reproducibility!
- CD44 is involved in cell adhesion, migration & signaling. It is key in inflammation and immune diseases & cancer. Good news: most commercial CD44 antibodies are highly specific and work well for: • Western blot • Immunofluorescence • Flow cytometry Full report: zenodo.org/records/1562...
- Reposted by Simon ClearyDelighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....
- Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:
- Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...
- Reposted by Simon ClearySome good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵
- Reposted by Simon ClearyIt’s official! 🎉 Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social ! 🔗 elifesciences.org/articles/104... I’m thrilled to share this story with you in a short thread 👇
- Reposted by Simon ClearyBioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
- Reposted by Simon ClearyFor this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
- PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues! Please forward to any suitable undergraduates/MSc students/research assistants. Info: kcl-mrcdtp.com/project/enha...
- Reposted by Simon ClearyPleased to see this out now in @jem.org 🔬 We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.
- William J. Branchett, Anne O’Garra @crick.ac.uk et al. reveal that type I signaling early during M. #tuberculosis infection favors #neutrophil swarming and limits CD4+ T cell–#macrophage interactions in #TB lesions, impeding TB disease control. rupress.org/jem/article/...
- Reposted by Simon Cleary🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4
- Reposted by Simon ClearyNew postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...
- PhD opportunity: please contact me if you know someone with a strong interest in respiratory science who would like to apply for a Sir David Jack PhD scholarship. Details here: www.bps.ac.uk/membership-a... Course fee waivers possible for outstanding international students.
- Reposted by Simon ClearyThrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight
- 🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽 📖 Read our paper here: doi.org/10.1126/sci... 🎬 Watch a summary: youtu.be/MttCA3GGWEM 🧵 Or keep reading for the key points! 🔑 1/19
- Reposted by Simon ClearyVav-Cre has been transformative for the field, but it is a pain in the a** of a line to work with. Has anyone made a better pan-hematopoietic line? Which one? How specific is it?
- Reposted by Simon ClearyNeeding some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?
- Reposted by Simon ClearyNew postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk Closing date 7th August. Please do consider applying! my.corehr.com/pls/coreport...
- Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways: rdcu.be/ewCMo Congrats Chou Chou, Hasina Outtz Reed and colleagues!
- Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury. rdcu.be/ewDHm
- Reposted by Simon ClearyVery excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo. CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...
- Reposted by Simon ClearyI’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
- Reposted by Simon ClearySpread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...
- Reposted by Simon ClearyOur Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social thorax.bmj.com/content/earl...
- Public access link: rdcu.be/er3Iq
- Interested in new ways to study interactions between cancers and the immune system? If yes, have a read of this article on mine and Longhui Qiu's recent work, featured in Nature Reviews Cancer's Tools of the Trade series: rdcu.be/er3Iq
- Reposted by Simon ClearyFor #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....
- Reposted by Simon ClearyMy PhD student isolated some liver endothelial cells and got this brilliant image showing the gradual transition of health EC to full EndMT in a very satisfying circle. #fluorescencefriday #fibrosis
- Reposted by Simon ClearyNeed help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help! www.eurobioimaging-access.eu/nodes/uk-node
- 🔬𝐔𝐊 𝐄𝐮𝐫𝐨-𝐁𝐢𝐨𝐈𝐦𝐚𝐠𝐢𝐧𝐠 𝐍𝐨𝐝𝐞 𝐬𝐞𝐜𝐮𝐫𝐞𝐬 £𝟏.𝟖𝐌 from @ukri.org This will: -Democratise access to cutting-edge biological and biomedical imaging -Support 200+ researchers yearly -Boost open science Thanks to BBSRC and MRC for this major upgrade! 🚀 Congrats to the entire UK Node team 👏 Link in replies⬇️
- Reposted by Simon ClearyVery excited about this paper that came online today! InterpolAI can predict missing image data from light microscopy to H&E to MRI for improved volumetric imaging and image analysis.
- Can a deep learning model know your data well enough to predict missing parts? InterpolAI accurately interpolates synthetic images between pairs of authentic images to “repair” tissue damage and reduce stitching artifacts across diverse modalities. @deniswirtz.bsky.social bit.ly/453o1i1
- Reposted by Simon ClearyYou did scRNA-seq of the lung, but can't decide on stromal annotation? Or trying to pick up Xenium probes? We got you! We wrote a review of stromal heterogeneity in the adult lung delineated by recent single-cell genomics studies. journals.physiology.org/doi/full/10....
- Reposted by Simon ClearyAngiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in @natcardiovascres.nature.com by Marle Kraft et al. rdcu.be/enhST
- Reposted by Simon Cleary🚨 We did it! Our latest work—led by my lab and the @lloydlab.bsky.social is now published in Nature Immunology! 🎉 Using single-cell spatial transcriptomics, we provide the first map of the airway wall. 🔗 www.nature.com/articles/s41... #spatialbiology #asthma #mastcells #lungimmunology
- Reposted by Simon Cleary*Paid internship opportunity* @biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and @focalplane.bsky.social If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇
- Amazing imaging and useful research from @daniyaljafree.bsky.social !
- Failing to Filter: Microvessel abnormalities highlighted in polycystic kidney disease – promising targets for therapy 📷 Daniyal Jafree et al @ucl.ac.uk Institute of Child Health Kidney Development and Disease lab @dmmjournal.bsky.social ➡️ bpod.org.uk/archive/2025...
- Our work featured on the cover of this month's J Exp Med!
- Our May issue is here! rupress.org/jem/issue/22... Cleary et al. (doi.org/10.1084/jem....) developed a new intravital technique for imaging pulmonary lymphatics. The cover depicts a 3D projection of a whole lung lobe with lymphatics (purple) and smooth muscle (white) labeled.
- Reposted by Simon ClearyOne week left to apply! Join my lab in beautiful Vienna for your #PhD studying #metastasis.
- 🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org
- Reposted by Simon Cleary🚨 Exciting news for #UKCellMicro2025! The meeting is now supported by the EMBO Young Investigator Programme We’re thrilled to have their backing for this year’s meeting. 🌟 🔗 Full details & programme: www.ukcellmicro.org #CellMicro #ECR #EMBO
- Reposted by Simon ClearyFancy an academic job in London? Apply below and come join us at our amazing institute! 👏🧪🧠 #PainResearch #PainScience
- The Wolfson SPaRC (Sensory, Pain and Regeneration Centre) is recruiting! Two posts available at Lecturer, Senior Lecturer or Reader position. Take a look! @kingsioppn.bsky.social #TranslationalResearch #SpinalCordandBrainRepair #HearingLoss #ChronicPain #Migraine www.kcl.ac.uk/jobs/111846-...
- Reposted by Simon ClearyThrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal! doi.org/10.1242/dmm.... We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)
- Excellent study putting together important pieces of the puzzle of why lymphatic endothelial cells resemble puzzle pieces! 🧩
- • Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵 www.nature.com/articles/s41... Laymen video: www.nature.com/articles/d41...
- Reposted by Simon ClearyWe are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare - any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...
- Nice news feature on Cathi Conrad's identification of a reservoir of functional haematopoietic stem cells in human lungs! www.ucsf.edu/news/2025/02/429531/how-our-lungs-back-bone-marrow-make-our-blood
- Awestruck by these cage-like structures that regulate escape of megakaryocytes from bone marrow into blood vessels. Congratulations to authors of this study, which I see is now also available as a reviewed preprint at eLife: elifesciences.org/reviewed-preprints/104963v1
- The megakaryocyte: trapped in a cage of its own making 𐂺 In this #preprint, @wclairemasson.bsky.social & colleagues report the discovery of novel structures controlling megakaryocyte protrusion events. Excellent #preLight from @simoncleary.bsky.social ⬇️ 👀 prelights.biologists.com/highlights/m...
- Reposted by Simon ClearyIntravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social doi.org/10.1084/jem....
- Check out our movie featured as Biomedical Picture of the Day! 'Bluetorial' in preparation!
- Captured in living mice: immune cells migrating in the lymphatic vessels of lungs and other tissues as they go about their business surveilling in cancer & inflammation settings 📹: @simoncleary.bsky.social & Longhui Qiu et al @ucsfmedicine.bsky.social in @jem.org ➡️: bpod.org.uk/archive/2025...
- Reposted by Simon Cleary🚨 We have TWO exciting open positions in our lab! 🚨 We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as: 🔬 Research Assistant www.kennedy.ox.ac.uk/jobs/researc... 💻 Bioinformatics Postdoc www.kennedy.ox.ac.uk/jobs/bioinfo... 📢 Please share!
- UK academics: If you know a talented undergraduate from a disadvantaged background who is interested in imaging research, encourage them to apply for these funded summer placements:
- Applications are now open for our Summer Studentships! ☀️🔬🦠 We’re looking for undergraduates to do paid research for 4-6 weeks this summer. See the projects on offer and check the participation eligibility requirements on our website. ⬇️ www.rms.org.uk/community/ne...
- A role for the druggable kinase TNIK in promoting vascular leak in inflammation! Grateful to have had the opportunity to contribute to this study: science.org/doi/10.1126/sciadv.adk6583
- Reposted by Simon Cleary1/x Online now: Our work on platelet aging and inflammation in @bloodjournal.bsky.social led by superstar PhD student Afra Anjum: ashpublications.org/blood/articl...
- Reposted by Simon ClearyNeutrophils (red) and Platelets (cyan) chasing each other in the murine ischemic stroke brain... (1/2 reduced speed)
