Nature Reviews Cancer
Nature Reviews Cancer is a monthly review journal for researchers working on cancer. We, the editors, highlight the most exciting topics in cancer research.
nature.com/nrc/
- 🥳 Our 7th most downloaded #REVIEW in 2025: Recent advances in therapeutic cancer vaccines #cancervaccines @NatResCancer #NRCtop10of2025
- In a recent Science Immunology paper, He et al. show that treatment with the chemotherapy carboplatin reshapes cardiac-resident macrophage populations, protecting against later heart disease. Check out this #researchhighlight for more deets! 👇
- 🥳 Our 8th most downloaded #REVIEW in 2025: Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection #cfDNA #liquidbiopsy @NatResCancer #NRCtop10of2025
- On #WorldCancerDay 🎗️💕 , we celebrate being #UnitedByUnique. In this #COMMENT, Mansouri, Zadeh et al. outline a framework to embed patients & the public into basic research, strengthening communication, equity and real‑world impact. 👇 📖 dlvr.it/TQlvx5
- 🥳 Our 9th most downloaded #REVIEW in 2025: The immune microenvironment of colorectal cancer #TME #colorectalcancer @NatResCancer #NRCtop10of2025
- 🚨 #REVIEW #PROGRESS 🚨 Fucosylation—the attachment of the dietary sugar L‑fucose to glycoproteins & glycolipids—is frequently altered in cancer. Bitaraf et al. outline its role in tumour progression and therapeutic response. 📖 👇
- 🥳 First up in #NRCtop10of2025: #10) Ageing, immune fitness and cancer #ageing #aging #ageingandcancer #agingandcancer @NatResCancer #NRCtop10of2025
- Get ready... 🚨 Starting Monday, we're counting down the top 10 most downloaded #REVIEW articles of 2025! 🚨 Don't miss it! 🎉 #NRCtop10of2025
- Our February issue is live now! ❄️ 💘 It features #REVIEWS on: - m6A RNA modifications - The role of concomitant medications on ICI efficacy - Neutrophil extracellular traps - Transcriptomic deconvolution 👇 dlvr.it/TQfqS0
- #JournalClub🚨 Pablo Siliceo & Alfredo Rodríguez discuss histoCAT, a method that offers interactive spatial analysis to reveal tumour tissue architecture and cell–cell interactions, highlighting the growing power of #SpatialBiology. 📖⬇️ dlvr.it/TQfjPk
- #Comment🚨 Cat tumour viruses mirror human oncogenic viruses. Beatty & Tu argue that comparative oncology in cats could accelerate prevention and treatment strategies for viral cancers. 📖⬇️ dlvr.it/TQdk2t
- #COMMENT 🚨 To preserve tumour architecture, cellular heterogeneity & the dynamic crosstalk that influences cancer, Fong and colleagues advocate for coordinated, cross-disciplinary and sustained efforts to promote the widespread adoption of tumour explants. 👇 📖 dlvr.it/TQZPW7
- #REVIEW 🚨 The fibroinflammatory microenvironment of PDAC influences progression & therapy response. @marasherman.bsky.social et al. outline the complex interplay between the stromal elements & present ways to develop better therapeutic strategies. 👇 📖
- #REVIEW 🚨 #AI agents perform complex tasks with minimal human oversight. This Review by @jnkt.bsky.social et al. discusses how AI could transform oncology & the challenges to address for efficient & safe use. 👇 📖
- Weekend reading 🚨 A comprehensive #Review on the dual role of the #cGAS–#STING pathway in cancer, emphasizing its involvement in both tumour suppression and promotion, which might underlie the limited clinical success of cGAS–STING targeting in cancer therapy. 📖👇
- ICYMI 🚨 #ResearchHighlight on a study published in @Nature demonstrating that strong oncogenic driver mutations undergo negative selection unless they occur in a permissive tissue context. 📖👇
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- Why not sign up to this fantastic meeting organized by Cancer Grand Challenges on #Cancer and the host at the Royal Society, London 17-19th June. Our Chief Editor @annaedart.bsky.social will be there! 👇
- ICYMI: #ResearchHighlight By incorporating lectins that target tumour-associated carbohydrate antigens, Zhou et al. engineered bispecific antibodies that induce effective T cell activation & tumour regression in various cancers. 📖 👇
- 🚨 #PERSPECTIVE 🚨 Reardon et al. explore how integrating machine learning into next-generation sequencing (NGS)-based molecular diagnostic workflows can enhance precision oncology. 📖 👇
- Happy 2026! Our first issue of the year is live! ❄️ It features articles on: - Identifying & targeting EMT tumour states - Metabolic cell death for therapy - Epigenetic regulation of T cell exhaustion - FLASH radiotherapy 👇 📖 https://bit.ly/4jp37...
- #Review🕯️🕯️🕯️ Luo, Kharas & Jaffrey explore how m6A RNA modifications regulate RNA stability, translation, splicing & immune responses in cancer and discuss challenges & opportunities for targeting the m6A machinery for cancer therapy. @kharaslab.bsky.social 📖 ⬇️
- ICYMI: #ResearchHighlight A study published in Science shows that liver zonation shapes hepatocellular carcinoma #HCC development, revealing metabolic vulnerabilities in liver cancer. @haozhulab.bsky.social
- In this recent #Comment, Sheila Mansouri, Gelareh Zadeh & Co outline the need for patient and public involvement and engagement (PPIE) ambassadors into basic cancer research pipelines. 📖 ⬇️ https://bit.ly/48UH3...
- #Review 🕯️🕯️🕯️ The ability of #macrophages to eliminate cancer cells is controlled by phagocytic checkpoints. Veillette&Co discuss targeting these checkpoints for cancer therapy and outline strategies to address therapeutic efficacy concerns. 📖⬇️
- Concomitant medications can influence ICI outcomes & represent a modifiable prognostic factor. Now, Young & colleagues explore immunomodulatory effects of common drugs + supplements & propose strategies to integrate this knowledge into clinical care.
- #REVIEW 🚨 Tumor heterogeneity shapes progression and treatment, yet bulk expression data fails to capture this. Now Dai et al. outline deconvolution methods that resolve cell-type-specific signals to maximize bulk transcriptomic data.
- Weekend reading 🕯️🕯️ In this #Review, Tang, Wang, Kroemer and Kang outline the regulatory mechanisms of #macropinocytosis, its implications for treatment strategies and potential as a target for enhancing therapeutic efficacy in oncology. 📖⬇️
- Check out this #ResearchHighlight 👀 A recent study reveals that the endoplasmic reticulum (ER) stress response in leukocytes plays a key role in mediating peripheral nerve damage caused by paclitaxel. 📖⬇️
- ICYMI 🚨 Although ferroptosis is emerging as a therapeutic vulnerability in cancer, clinical translation has faced hurdles. In this #Review, Wahida & Conrad review its biology, immunogenicity & steps towards clinical translation 📖 👇
- ICYMI 🚨 Neurotoxicity impacting the central & peripheral nervous systems is an adverse effect of cancer therapies. In this #Review, Karschnia et al. outline the mechanisms that underlie the clinical symptoms & the need for interventions to treat it. 👇
- ICYMI 🚨 In this #Review, Kennel & Greten highlight the role of immune cells in CRC development, progression & metastasis. They emphasize the need for novel strategies to enhance immunogenicity & CRC patient stratification to improve outcomes. 👇 📖
