Journal of Clinical Investigation
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
- Unraveling TIME: CD8+ T cell- and CXCL11-driven endocrine resistance in breast cancer: doi.org/10.1172/JCI2... Tim Kong & Cynthia X. Ma provide a Commentary on Fabiana Napolitano: doi.org/10.1172/JCI1...
- The fingertip has notable regenerative capacity, yet the underlying mechanisms—especially the role of lymphatics—have been debated Benjamin Levi & team now find reducing lymphatic vessels in a mouse amputation model accelerates bone breakdown & enhances regeneration: doi.org/10.1172/JCI1...
- Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation
- Behind the Scenes: First author Neda Vishlaghi takes a closer look at the mouse digit tip before amputation.
- Could curbing inflammation prevent the progression of TP53-mutant clonal hematopoiesis to myeloid blood cancers? Yan Liu, @oawlab.bsky.social & team find mutant p53 in mice promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment: doi.org/10.1172/JCI1...
- Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment
- Current methods for tracking cognitive decline in Alzheimer’s disease are invasive and expensive Zhaoyuan Gong & team now report on axonal density index as a biomarker detected by diffusion MRI for predicting dementia risk & monitoring AD progression: doi.org/10.1172/JCI1...
- It’s about TIME (tumor immune microenvironment) for breast cancer Here, Carlos L. Arteaga & team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: doi.org/10.1172/JCI1...
- CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer
- Exploring the biology of metastatic hormone-sensitive prostate cancer: on the road to precision medicine In this Review, Alice Bernard-Tessier & @mishabeltran.bsky.social discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI2...
- Over 100 years ago, platelets were observed to interact with neutrophils in blood clots Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
- Immobilized IgG-containing immune complexes require platelets to recruit neutrophils during inflammation
- Rhythms of risk: the intersection of clocks, cancer, and chronotherapy In this Review, Rebecca M. Mello et al. highlight the promise of integrating circadian biology into precision oncology: doi.org/10.1172/JCI1...
- A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
- Behind the Scenes: Long-time collaborators and first and second authors, Dr. Zheng Zhong and Dr. Xinang Cao—a spouse team—explore nature in the Yellow Mountains of China!"
- Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer
- CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models Antonio Carlos Tallon-Cobos & team present a new ependymoma model and demonstrate a promising immunotherapeutic approach for this pediatric brain cancer: doi.org/10.1172/JCI1...
