Michelle Percharde
Transposons, chromatin, development. Group leader @ the MRC LMS in London and UKRI FLF. Mum of 2, she/her. Www.perchardelab.com
- 🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....
- Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
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- Yes true! Or where they part of the problem… 🤣
- I’m not sure it’s a good thing 😂 I miss papers with 3 figures and one finding. Poor person who has to present journal club on this paper!
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- Thank you Rob! 🇬🇧
- Very excited to be part of this prestigious programme, thank you @embo.org !
- Congratulations to LMS group head @mpercharde.bsky.social who has been selected as one of this year’s EMBO Young Investigators! 🌟 The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields. @embo.org
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View full threadExcellent news, congratulations Michelle!
- Thank you Deborah!
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- Thanks Antoine!
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- Thanks Abby!
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- Thank you!
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- Thank you for your support Lila!
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- 🥰🥰🥰 thank you. Looking forward to more TEtime together ;)
- 🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
- Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
- ☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness. bit.ly/49iFC7C
- Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem... Looking forward to seeing you there!
- 🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
- Come be our head of bioinformatics at @mrc-lms.bsky.social ! Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
- Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
- Great to see this out in final form. Congrats Abby!
- 🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
- The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT! lms.mrc.ac.uk/work/vacanci...
- LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔
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- I feel like the clusters of pistachios (?) are significant here hmmm
- We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
- Good things come to those who wait! 😅 congratulations @lab-turner.bsky.social on this exciting work and what a day for @bryonyleeke.bsky.social 💪🏼
- The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...
- Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.
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- I love GRCs..they feel friendly and much more accessible previously as a postdoc and even now as a mid-(still early??) career PI than many meetings. And looking forward to the GRC epigenetics one in Aug!
- Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25. lms.mrc.ac.uk/work-and-stu...
- 💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
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- Very nice, congratulations! I remember seeing and liking this story at ICTE. Of course you didn’t have to convince me that TEs can play important roles in development… 😍
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- Can’t wait! 😍
- 1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
- Very cool story, I remember really enjoying the talk at ICTE!
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- “Success” - Interpol
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- You’ve read 3 books already???! I’ve barely read a menu
- But they seem like such a good idea at the time…
- how many have you got? #phdlife #academicchatter
- doi.org/10.1126/scia... very happy to have contributed with @bryonyleeke.bsky.social to this fascinating study from Jesus Gil’s lab @mrc-lms.bsky.social. SMARCA4 inhibition leads to repeat element dysregulation, cGAS/STING activation and enhances immune cell clearance of senescent cells
- 🧪Degrading SMARCA4 helps the immune system eliminate zombie cancer cells, reducing tumour size in mice! This new approach, published yesterday in Science Advances, was developed as a collaboration between the LMS, @imperialcollegeldn.bsky.social and @umontreal.ca
- Tell me you're a science parent without saying anything...thanks for the new calculator @alexisbarr.bsky.social
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- I’m just so mature as well as being old
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- +1 for @genesdev.bsky.social too - has got lost a bit in recent years with all the CNS subsidiaries…
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- Woooooahhhh…can I be an affiliated CNRS researcher 😂
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- Very cool! Is there a LINE1 in rDNA of any other species?
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- Best of the monkey islands. You fool! You’ve given cheese to a lactose-intolerant volcano. Run for your liiiiiiffffffe!
- The @mrc-lms.bsky.social is recruiting for Programme Leader Track (PLT) group leaders - come work with us! Supportive and collaborative colleagues, fascinating mechanistic science, generous funding and facilities, and a new building with nice views of London 😍 shorturl.at/VuVxX
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- oooo I love hot chip 🤣 🎶
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- Well…I haven’t been very productive recently
- Sarah j Maas books - ACOTAR series and others. Although beware they are addictive and will then steal all of your spare time…
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- Come back soon Fabian! It was great hosting you @mrc-lms.bsky.social and I enjoyed our TC chats about PGCLCs
- I love a good reporter! TE reporters for capturing distinct hESC states. Looking forward to reading #TEsky
- The latest paper from the Di Stefano lab showing the power of using transposable elements as reporters of different human pluripotent states! www.embopress.org/doi/full/10....
- Heading home after the @embl.org PhD symposium #biologyoutsidethebox - real pleasure to talk a bit on our work #beyondthedogma on TEs & also share about being a women in science. Loads of cool talks from v.diverse topics! #dinosaurDNA . Thanks for the invite!!
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- Ah I’ve missed these!
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- “Assassin bugs”?? Damn. Mice are so boring
- Welcome Cedric! #TEsky
- What better place than the city of lights to make my transposition to 🦋. Look at all that blue sky!
- Welcome to the good site!
- Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
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- Oh yes I love this paper but missed the MERVL CRISPRa! Thanks a lot; will take a look.
