Turner Lab
Account of the Turner lab at the Francis Crick Institute in London. We study sex chromosomes and their impact on health and disease. Rotating curation by lab members.
crick.ac.uk/research/labs/james…
- Reposted by Turner LabMore marsupial fun from @lab-turner.bsky.social. Congrats @sermenchero.bsky.social
- Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Turner Lab[Not loaded yet]
- Paper alert! 🚨 Something new from us, and this time it's not sex chromosome related 😱 All led by @sermenchero.bsky.social who used the opossum as a model to understand developmental heterochrony. Transcriptional and morphological progression of dev programs are decoupled www.cell.com/developmenta...
- Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...
- Reposted by Turner LabYou can also read a research briefing about the paper here: www.nature.com/articles/d41...
- Reposted by Turner LabWe are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training. The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social. #job #internship; see info below...
- We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
- In eutherian (placental) mammals, the early embryo “wipes” its epigenome, but we don't know why. Many things happen early in placental mammalian embryos, and all in very quick succession: the embryo genome activates, pluripotent stem cells appear, and the placental precursor cells are formed
- We are excited to share our latest preprint led by Ruta Meleckyte and Waz Varsally! www.biorxiv.org/content/10.1... We generated a set of human isogenic induced pluripotent stem cells (hiPSCs) that are autosomally identical but differ in sex chromosome composition: XX, XY or monosomic X
- Reposted by Turner LabRegistration and abstract submission for YEN 2025 is officially open! We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025. Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
- We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬 What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬 www.science.org/doi/full/10....
- This work was only possible because of the amazing facilities at @crick.ac.uk and our wonderful collaborators.
- Great summary of our latest paper studying the role of Y genes in spermatogenesis. ⬇️
