Dr. Sedona Murphy
Group leader @mpi-mg, Berlin
Chromatin tracing, epigenetics, development. Equity and advocacy in academia.
- Reposted by Dr. Sedona Murphywww.nature.com/articles/s41... happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
- Reposted by Dr. Sedona MurphyTerrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains
- How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...
- Reposted by Dr. Sedona MurphyNew Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
- Reposted by Dr. Sedona MurphyPreprint alert: Jiangyuan Liu developed a new workflow for chromatin loop calling across Hi-C datasets, e.g., during differentiation. Most loops are shared between datasets/cell states. Important work for all interested in chromatin loops and how to identify them! www.biorxiv.org/content/10.6...
- Reposted by Dr. Sedona MurphyNow online in Cancer Discovery @aacrjournals.bsky.social: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by Michael Lee, Yuannyu Zhang, Jian Xu, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social
- Reposted by Dr. Sedona MurphyJoin our virtual seminar! @sedonamurphy.bsky.social presents cutting-edge research on 3D genome organisation & epigenetic memory in development, moderated by @stefanschoenfelder.bsky.social 📅 Jan 8, 4pm UK 💻 Zoom Register: us02web.zoom.us/webinar/regi... #3DGenome #Epigenetics #ChromatinBiology
- Reposted by Dr. Sedona MurphyActivator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
- Reposted by Dr. Sedona MurphyAs usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-... Know of a relevant event that’s missing? Please reply below
- Reposted by Dr. Sedona MurphyExcited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...
- Reposted by Dr. Sedona MurphyOur preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- Reposted by Dr. Sedona MurphyVery happy to share the published version of our study on the benefits of sodium sulfite + trolox (SST) as oxygen scavenger for #DNA-PAINT - now out in Small! Thanks to the reviewers for helpful comments and again congrats, Becky, on your PhD's first paper!! tinyurl.com/54m2pt9c
- Reposted by Dr. Sedona MurphyExcited that SpaceBar is now out in Nature Methods!🥳 We combined clone tracing with spatial transcriptomics to untangle what drives gene expression in tumors: a cell's identity or its neighborhood? Most genes were driven by location, but some showed strong clonal patterns. rdcu.be/eVhpc
- Reposted by Dr. Sedona MurphyAfter a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...
- Reposted by Dr. Sedona MurphyLovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
- Reposted by Dr. Sedona MurphyCan one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.
- CUT&ID for simultaneous profiling of protein-DNA and protein-protein interactions biorxiv.org/content/10.64898/20…
- Reposted by Dr. Sedona Murphy🧬 Are you interested in synthetic biology, CRISPR-Cas9 genome editing and cutting-edge genomics? Apply by 07.01.2026 to join Stefan Mundlos’ lab @stemundi.bsky.social at the MPIMG. #IMPRS-BAC #gradschool! @nataliabenetti.bsky.social 👉 www.molgen.mpg.de/5124667/Mund...
- Reposted by Dr. Sedona MurphyThrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...
- Reposted by Dr. Sedona Murphy@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
- Reposted by Dr. Sedona MurphyMapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
- Reposted by Dr. Sedona MurphyWe just released IRIS (7+yrs project), a tech we believe will transform cell biology by pairing high-resolution cell images with matched #scRNAseq, letting us interpret cellular form by its molecular ground truth. Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al. shorturl.at/zgY8Z
- Reposted by Dr. Sedona MurphyAre you a #devbio postdoc planning to go on the job market in 2026? Then this is the initiative for you! Offering training, networking, mentoring and profile-raising components, Development's PI Programme can give you that extra support you might need while navigating this challenging time...
- Apply for our Pathway to Independence (PI) programme, supporting postdocs in #devbio and #stemcell research during the transition to their first group leader position: www.biologists.com/grants/devel... Application deadline: 2 February 2026.
- Reposted by Dr. Sedona Murphy🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then! www.science.org/doi/10.1126/...
- Reposted by Dr. Sedona MurphyBah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
- Reposted by Dr. Sedona MurphyWant to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD? Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool! 👉 www.molgen.mpg.de/5094682/Fuey...
- Reposted by Dr. Sedona MurphyNow online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
- Reposted by Dr. Sedona MurphyPigeons may be able to sense magnetic fields via electric currents in their inner ears. scim.ag/4p1a4rU
- Reposted by Dr. Sedona MurphyWe are hiring! Interested? Apply here: go.mbl.edu/AS1887
- Reposted by Dr. Sedona Murphy🔬 Hot #PhD topic: Single-molecule fluorescence and super-resolution microscopy! Use quantitative nanoscale imaging to map nuclear organization. Apply by Jan 7 to join Johannes Stein’s Lab @jmstein.bsky.social & #IMPRS-BAC #gradschool! 👉 www.molgen.mpg.de/5098010/stei...
- Reposted by Dr. Sedona MurphyI'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...
- Reposted by Dr. Sedona MurphyCheck out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...
- Reposted by Dr. Sedona MurphyWe are excited to participate this year again in the VBC summer school! If you want to work with me and my amazing student Maria, apply!
- The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Christa Buecker from Max Perutz Labs Vienna is recruiting! Please share training.vbc.ac.at/summer-school/
- Reposted by Dr. Sedona MurphyWe are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below: (TLDR; low-affinity motifs matter as pioneers!)
- Reposted by Dr. Sedona MurphyTo probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
- Reposted by Dr. Sedona MurphyLast reminder: We’ll see you bright and early at 9:30 AM EST on the 25th to kick off #chromatin2025! Fantastic lineup of speakers with discussion to follow each talk. Don’t forget to register for this virtual meeting if you haven’t yet: bit.ly/chromatin-2025
- Reposted by Dr. Sedona MurphyMajor new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Dr. Sedona MurphyIMPRS-BAC #gradschool: Our new groupleader @sedonamurphy.bsky.social has an open PhD project in her lab. Topic: Spatial feedback between epigenetic regulation and chromatin regulation. Apply by Jan 7, 2026! 👉 www.molgen.mpg.de/5091778/Murp...
- Reposted by Dr. Sedona Murphy☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness. bit.ly/49iFC7C
- Reposted by Dr. Sedona MurphyGreat career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology. More: www.imp.ac.at/career/open-...
- Reposted by Dr. Sedona Murphy𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
- Reposted by Dr. Sedona MurphyWe recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...). We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
- Couldn’t ask for better colleagues as a new group leader ☺️
- We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute! Read more about their work: --> www.molgen.mpg.de/2025-10-31-n... All three are recruiting in the IMPRS PhD Call! --> www.molgen.mpg.de/IMPRSPhDproj...
- Reposted by Dr. Sedona MurphyOur latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
- Reposted by Dr. Sedona MurphyAnd we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
- 📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
- Reposted by Dr. Sedona Murphy1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. 👉 surl.li/cgwqcq A thread 🧵
- Reposted by Dr. Sedona Murphy@lucianomartelotto, not on Bluesky, on a new Spatial RNA imaging method, PRISM. www.nature.com/articles/s41... Now added to #SingleCell #Spatial #Method bit.ly/scmethodstable
- Reposted by Dr. Sedona Murphy1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
- Reposted by Dr. Sedona Murphy
Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49... - Reposted by Dr. Sedona MurphyThrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...
- Reposted by Dr. Sedona MurphyMy lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...
- Reposted by Dr. Sedona MurphyThe Skok Lab is recruiting an experienced computational scientist to lead single-molecule epigenomic and 3D genome analysis. We integrate long-read sequencing with Hi-C/Hi-ChIP, scmulti-omics, and machine-learning to explore chromatin topology, and gene regulation.
- Reposted by Dr. Sedona MurphyLooking forward, I am launching my lab in the @mitkochinstitute.bsky.social and IMES at @mit.edu, and will continue studying how the unique regulatory landscape of ecDNA enables tumor evolution. We're looking for creative scientists to push this frontier - if you're interested, get in touch!
