Adrian Bracken
Epigenetics & Chromatin Biology | Polycombs in Development & Disease | Cancer Genetics | Professor of Chromatin Biology, Trinity College Dublin | www.brackenlab.com
- Reposted by Adrian BrackenJust one week to go until Edith Heard will be joining us for the All-Ireland Chromatin Consortium webinar on 'The Epigenetic Dynamics of X Inactivation in Development and Disease' 🧬 Registration link: us06web.zoom.us/webinar/regi...
- After a short break in our webinars we are delighted to be back up & running this month! First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬 Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬 Registration details 👇
- Reposted by Adrian Bracken@adrianbracken.bsky.social we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October! Please share this with your followers to let them know you will speaking, and to register & submit today to join us 🔗 bit.ly/4rC6B45
- Reposted by Adrian BrackenSynovial sarcoma is driven almost exclusively by a single oncofusion – SS18-SSX For years, the assumptions on disease mechanisms were simple: ➡️ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity Our new study shows that assumption was wrong 🧵👇 www.biorxiv.org/content/10.6...
- Reposted by Adrian BrackenAfter a short break in our webinars we are delighted to be back up & running this month! First up, on Jan 30th we will be joined by @lucas.farnunglab.com from @harvardmed.bsky.social 🔬 Shortly after, on Feb 13th we will be hosting @heardlab.bsky.social from @crick.ac.uk 🧬 Registration details 👇
- Reposted by Adrian BrackenTwo alternative isoforms of PRC2 accessory subunit AEBP2 modulate developmental Polycomb functions in opposite ways - with broadly-expressed AEBP2L acting as an intrinsic inhibitor in somatic cells @adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues www.embopress.org/doi/full/10....
- Reposted by Adrian BrackenWe are delighted that @genesdev.bsky.social have selected our (w/ @adrianbracken.bsky.social) Weaver syndrome paper artwork as the November cover! This piece was made by my incredibly talented niece, Gina 'Dna Vinci' Ronan. @ucddublin.bsky.social @tcddublin.bsky.social @ucd-sbbs.bsky.social
- 1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. 👉 surl.li/cgwqcq A thread 🧵
- 2/ 🧵🌍 Firstly, a huge thank you to first authors Marlena Mucha, Zhihao Lai, Nicholas McKenzie, Francesca Matra. This was a joint effort with @davidovichlab.bsky.social with wonderful collaborations with labs at Radboud, NKI, USC & Garvan Institute 🙏🧵
- 3/ PRC2 is a chromatin repressor complex essential for development and deregulated in disease. While several accessory proteins enhance PRC2, no endogenous inhibitor in somatic cells had been identified — until now! ⚡️
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View full thread16/ 📖 Again, please check out the full paper here: surl.li/cgwqcq Huge thanks again to all collaborators and co-authors who made this project possible! 🙏
- Reposted by Adrian BrackenAbsolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see👇
- 🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma
- Reposted by Adrian Bracken🧵1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!👇 #CancerResearch #Epigenetics #Chromatin #Lymphoma
- Reposted by Adrian Bracken2/ Firstly, this was a fantastic collaborative effort that would not have been possible without super-talented co-first author @dr-chromatin.bsky.social, and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social.
- Reposted by Adrian BrackenDelighted that our work on EZH2 dominant negativity in Weaver syndrome is now out in Genes & Development! This exciting work on chromatinopathies 🧬 was in collab with @adrianbracken.bsky.social and spearheaded by Orla Deevy. @ucddublin.bsky.social @ucd-sbbs.bsky.social www.ucd.ie/newsandopini...
- Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
- Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
- Reposted by Adrian Bracken🧬🧪Exciting chromatin research conference hosted by @aicc-ireland.bsky.social in May! The deadline for poster/talk abstracts is April 28, see details in the post below.
- We are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today! Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters! allirelandchromatinconsortium.ie/annual-meeti...
- Reposted by Adrian BrackenWe are very excited to launch the registration for our 2025 symposium on 'Chromatin, Epigenetics and Transcription' today! Join us at @tcddublin.bsky.social on May 28th for this event featuring keynote, new PI and PhD/postdoc talks and posters! allirelandchromatinconsortium.ie/annual-meeti...
- Reposted by Adrian Bracken1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...
- Reposted by Adrian BrackenLooking forward to welcoming @peterlewislab.bsky.social from @uwmadison.bsky.social for our March webinar on 'Dissecting the Biochemical Complexes Governing Gene Silencing' on March 28th! Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
- Reposted by Adrian BrackenWhat a week it has been for our @uniofgalway.bsky.social committee members @jgahan.bsky.social and @thecocodium.bsky.social. Congrats on the grant successes from @researchireland.bsky.social and @wellcometrust.bsky.social respectively! Keep an eye out for job ads from them soon 👀
- Reposted by Adrian BrackenComing up this month on Feb 28th- we will be joined by @arnausebe.bsky.social from the @crg.eu for his webinar on 'The origin and early evolution of animal regulatory genome architecture'. Registration details here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
- Reposted by Adrian BrackenJust a few days left to submit your abstract for our #Epigenetics2025 conference in Belfast! genetics.org.uk/events/epige...
- Reposted by Adrian BrackenJoin us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb! Don't miss this chance to share your research & network with experts in the field. genetics.org.uk/events/epige...
- Reposted by Adrian BrackenCongratulations to all authors on this very interesting work! Regarding EZH1, it aligns well with what our group and Danny Reinberg's group have proposed based on structural and functional data.
- Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
- Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
- 🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
- Reposted by Adrian BrackenOur first 2025 webinar is coming up in a few weeks - Jan 31st! Mark your calendars! @davidlabmsk.bsky.social will join us for her webinar on 'Turning back the clock: Targeting a new metabolism-epigenetic axis in T-cells.' Registration: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
- Join us for Luciano Di Croce’s webinar tomorrow. Registration links below 👇
- Our final webinar before Christmas 🎅 is coming up! We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'. Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
- Reposted by Adrian BrackenOur final webinar before Christmas 🎅 is coming up! We will be joined by Luciano Di Croce for his webinar on 'Dissecting Dynamics of Chromatin Function in Cell Differentiation and Cancer'. Register here: us06web.zoom.us/webinar/regi... @activemotifusa.bsky.social
