Michelle Percharde
Transposons, chromatin, development. Group leader @ the MRC LMS in London and UKRI FLF. Mum of 2, she/her. Www.perchardelab.com
- Reposted by Michelle PerchardeNew preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
- 🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....
- Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
- Very excited to be part of this prestigious programme, thank you @embo.org !
- Congratulations to LMS group head @mpercharde.bsky.social who has been selected as one of this year’s EMBO Young Investigators! 🌟 The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields. @embo.org
- Reposted by Michelle PerchardeCongratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: embo.org/press-releases/twen…
- 🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
- Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
- Reposted by Michelle Percharde📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below
- ☕ @katerinakraft.bsky.social @sedonamurphy.bsky.social @mattjones.bsky.social et al. identify extrachromosomal DNA(ecDNA)-interacting elements (EIEs) enriched for #TransposableElements in #ColorectalCancer. EIE 14 integrated within ecDNA acts as an enhancer to promote cancer fitness. bit.ly/49iFC7C
- Reposted by Michelle PerchardeRegister now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025! Spaces are limited, register here: www.symposia.org.uk/courses/stem...
- Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem... Looking forward to seeing you there!
- 🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
- Reposted by Michelle PerchardeWe are launching 11 new #PhD opportunities today! If you would like to contribute to the research at the LMS apply today! #medicalscience #lifescience
- Reposted by Michelle PerchardeWe have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...
- Are you interested in doing a #PhD in #cancerresearch? 🧪🧑🔬👨🏽🔬👩🏿🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Find cancer cures for #youngpeople? Applications for our fully funded 4-year PhD programme starting in Autumn 2026 are open! bit.ly/4mHbPIH #uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick
- Reposted by Michelle PerchardeWorld’s first AI-designed viruses a step towards AI-generated life. #Nature Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria. www.nature.com/articles/d41...
- Come be our head of bioinformatics at @mrc-lms.bsky.social ! Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...
- Reposted by Michelle Perchardeit appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
- Reposted by Michelle PerchardeJoin the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!
- Reposted by Michelle PerchardeA new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
- 🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
- Reposted by Michelle PerchardePaper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
- The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT! lms.mrc.ac.uk/work/vacanci...
- Reposted by Michelle PerchardeThis should almost have an international reach: about what the rainbow flag means for queer people, by Oslo Pride.
- LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔
- Reposted by Michelle PerchardeI love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬
- Reposted by Michelle PerchardeIn this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation: doi.org/10.1242/dev....
- The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...
- Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.
- Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25. lms.mrc.ac.uk/work-and-stu...
- Reposted by Michelle PerchardeI am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal haematopoietic processes and haematological cancers. www.nature.com/articles/s41...
- Reposted by Michelle Percharde🚨🚨#Hiring! 3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG 📆 Apply by 23rd May 2023 🔗Details below @sebioldev.bsky.social Please RT!🙏
- Reposted by Michelle PerchardeBarbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.
- Reposted by Michelle PerchardeNew preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
- Reposted by Michelle PerchardeJoin our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
- Reposted by Michelle PerchardeChromatin & transcription meeting is back again. Register your interest here www.biochemistry.org/events-and-t...
- Reposted by Michelle PerchardeOnly a couple of months left until our official QMUL Centre for Epigenetics Launch Conference! We will have an amazing list of guest speakers, including Michelle Percharde @mpercharde.bsky.social from MRC LMS, UK. Spaces are limited.
- Reposted by Michelle Percharde
- The de-extinction company Colossal Biosciences wants to bring back the mammoth, and it’s starting with a woolly mouse. Read more here: buff.ly/xKPLn1c
- Reposted by Michelle PerchardeThey have created Schrödinger’s NIH employee 2/2
- Reposted by Michelle PerchardeThis is my science jobs feed. Do you have an opening in your Lab or Department? Did you come across a cool job opening? Just type #sciencejobs for post to appear on the feed. #neuroskyence #academicsky #womeninstem #medsky 🧠 🧪 🧬 🪰 🌱 bsky.app/profile/did:...
- Reposted by Michelle PerchardeExcited to announce new editorial leadership with Professor Andrew Dillin as Editor-in-Chief and Dr. Eric Sawey as Executive Editor, expanding the journal’s scope to include exciting new areas of molecular and cellular biology. bit.ly/genesdevpr
- Reposted by Michelle PerchardeWe are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.
- But they seem like such a good idea at the time…
- how many have you got? #phdlife #academicchatter
- Reposted by Michelle PerchardeIt’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
- doi.org/10.1126/scia... very happy to have contributed with @bryonyleeke.bsky.social to this fascinating study from Jesus Gil’s lab @mrc-lms.bsky.social. SMARCA4 inhibition leads to repeat element dysregulation, cGAS/STING activation and enhances immune cell clearance of senescent cells
- 🧪Degrading SMARCA4 helps the immune system eliminate zombie cancer cells, reducing tumour size in mice! This new approach, published yesterday in Science Advances, was developed as a collaboration between the LMS, @imperialcollegeldn.bsky.social and @umontreal.ca
- Tell me you're a science parent without saying anything...thanks for the new calculator @alexisbarr.bsky.social
- Reposted by Michelle PerchardeThe international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring? Apply before Feb 15th 📌
- Reposted by Michelle PerchardeNew research from Steve Cutty and @alexisbarr.bsky.social published in the British Journal of Cancer shows the protein p21 promotes survival in lung cancer cells strengthening the rationale for targeting p21 as a cancer treatment. This work was also funded by @cancerresearchuk.org
- The @mrc-lms.bsky.social is recruiting for Programme Leader Track (PLT) group leaders - come work with us! Supportive and collaborative colleagues, fascinating mechanistic science, generous funding and facilities, and a new building with nice views of London 😍 shorturl.at/VuVxX
- I love a good reporter! TE reporters for capturing distinct hESC states. Looking forward to reading #TEsky
- The latest paper from the Di Stefano lab showing the power of using transposable elements as reporters of different human pluripotent states! www.embopress.org/doi/full/10....
- Reposted by Michelle Percharde[This post could not be retrieved]
- Heading home after the @embl.org PhD symposium #biologyoutsidethebox - real pleasure to talk a bit on our work #beyondthedogma on TEs & also share about being a women in science. Loads of cool talks from v.diverse topics! #dinosaurDNA . Thanks for the invite!!
- Reposted by Michelle PerchardeNice to see our latest review published in @natrevmcb.bsky.social today – a collaborative exploration of mammalian extraembryonic development with @cwhanna.bsky.social for an invaluable epigenetic focus. @srinivas-lab.bsky.social www.nature.com/articles/s41...
- Reposted by Michelle PerchardeVery happy to share the latest preprint from the lab. We find that during cell competition, winners induce an increase in proline metabolism in loser cells, and this drives their elimination through repression of the integrated stress response. biorxiv.org/cgi/content/...
- Reposted by Michelle PerchardeInterested in a #postdoc in Edinburgh working on #interdisciplinary #epigenetics and having this view on your morning commute? Upcoming opportunities to apply for funding below 🧵 1/3. Get in touch if you are interested.
- Welcome Cedric! #TEsky
- Reposted by Michelle PerchardeExcited about prokaryotic chromatin and its role in pathogenic bacteria? Ambitious project to systematically characterize chromatin across ESKAPE pathogens! Wet & dry lab – Fully funded PhD available in our lab. Please share! www.findaphd.com/phds/project... #PhDPosition #Microbiology #Chromatin
