We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements.
www.genesdev.org/cgi/doi/10.1...LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells
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