Junjie Guo
Associate Professor @YaleNeuro • co-Director of Graduate Studies @Yale_INP • @YaleRNA • RNA Neurobiology • Neurodegenerative disease • Immigrant • 🐶 dad • Alum @WhiteheadInst @HopkinsNeuro @PKU1898 🏳️🌈
- Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
- Amazing! Congrats!!
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- Happy Birthday! 🎉
- Oh goody...Andrew Huberman is going to be a commentator on CBS News. I first learned of him when he did a 4+ hour podcast with Director Bhattacharya (also the first time I heard Bhattacharya on a podcast). 1/7
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- That never stopped a certain family in the WH
- We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867
- Congratulations Cate!
- Excited to publish our work on how mutations in the muscle-specific ribosomal protein RPL3L drive severe heart disease. This is Part I of a larger body of work led by Michael - stay tuned for Part II on how specialized ribosomes function in normal physiology www.nature.com/articles/s44...
- Thrilled to share our research on how mutations in the muscle-specific ribosomal protein RPL3L, a paralog of RPL3, cause a rare infant heart disease. Hotspot mutations are both proteotoxic and induce unproductive splicing in RPL3 mRNA, preventing phenotypic rescue. rdcu.be/eYkC7
- Awesome! Congratulations Xuebing!
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- New article @natneuro.nature.com by @yaleneuro.bsky.social Suzhou Yang & @kavliatyale.bsky.social Postdoc Fellow @zhenlei.bsky.social, highlighting studies by @frattalab.bsky.social Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS @yalerna.bsky.social www.nature.com/articles/s41...
- Excited to see this beautiful art, commissioned from the Chinese artist 懒云居画 (@subaiweipainting on Instagram), on this month's cover of Nature Neuroscience! @natneuro.nature.com @yaleneuro.bsky.social @yalerna.bsky.social @kavliatyale.bsky.social @wutsaiyale.bsky.social
- Our October issue is now live! www.nature.com/neuro/volume...
- Also check out this video from the artist showing the creative process: www.bilibili.com/video/BV1eKK...
- I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
- Congratulations Sinha lab!
- Grrrr. We don't call protein phosphorylation or acteylation epiproteomics. So let's not call RNA modification epitranscriptomics. In fact, realisitically, epigenetics has so many definitions, some of them non-overlapping, that this whole epi-XXXX (genetics/genomics whatever) is just not helping us.
- But have you heard of the "RNome"? humanrnomeproject.org
- Excited to see the work by @Yale_INP student Suzhou Yang w/ collabs @yaleneuro.bsky.social iPSC core @jdpereira.bsky.social and @mayoclinic.org @gendron_tania on #C9orf72 #ALS & #FTD finally out in @natneuro.nature.com! @wutsaiyale.bsky.social @kavliatyale.bsky.social www.nature.com/articles/s41...
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- Thank you Adam!
- Read it here: rdcu.be/eAcNv
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- Congrats!!
- Really just had something like this feeling this afternoon. It’s the high that keeps you coming back for more
- Nicely said. I'd also add that not knowing is equally exciting!
- This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
- Super cool!
- Congratulations to Yale INP student in the lab, Denethi Wijegunawardana, and all other 2025 @hhmi.org Gilliam Fellows! @yaleschoolofmed.bsky.social @yaleneuro.bsky.social @yalerna.bsky.social www.hhmi.org/programs/gil...
- RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- Amazing! Congrats!!
- New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
- Very cool!!
- Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
- AWESOME! Congratulations! 🍾
- New paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...
- So cool! Congrats Christine!
- Riboregulation of protein folding 👀 new cool work from @christinemayr.bsky.social
- New paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...
- Excited to welcome Dr. Katie Copley as a new postdoc in our lab @yaleneuro.bsky.social! She recently completed her PhD in the Shorter lab at UPenn and did amazing work on designing small RNA chaperones to counteract TDP-43 pathology in ALS-FTD. @yalerna.bsky.social
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- That's a big win 💪
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- Hang in there! 💪
- #RNA dysfunction in aged neurons 🧠
- Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...
- For those of you at #RNA2025, make sure to check out Lian-Huan's talk today on her genetic screens on the bidirectional transcription of C9 repeat expansion in ALS-FTD 🚨🚨🚨
- 🎉 Congratulations to the recipients of this year’s RNA Center Travel Awards We’re proud to support the exciting work of: Haejeong Lee, Tanja Hann, Dingyao Zhang, Lianhuan Wei Your dedication to advancing RNA research inspires us all. Safe travels and enjoy the conference! ✈️🧬 #RNA2025
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- Because monosyllabic words remind me of a certain president
- Celebrating @Yale_INP graduates👨🎓👩🎓 at the @yalegsas.bsky.social commencement 🎉🎉 @marinap63.bsky.social @schandralab.bsky.social photo by @neuralnandy.bsky.social
- Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
- Unbelievable... I'm so sorry and hope this dark period will soon pass
- Morning dog walk in Wooster square, New Haven 🌸🌸🌸
- Congratulations to Dr. Zhen Lei in the lab, who just received a Kavli Institute of Neuroscience Postdoctoral Fellowship! @kavliatyale.bsky.social
- He will be co-mentored by @davidbreslowlab.bsky.social to apply a microscopy-based 🔬 screening platform to understand mechanisms driving protein mislocalization in neurodegenerative disease 🧠
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- Surely it depends on the dollar amount?
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- Come back soon!
- Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12
- Congratulations Alex and the team!
- 🔥🔥🔥New work from @jimmy-ly.bsky.social and @iaincheeseman.bsky.social on the numerous distinctly localized protein isoforms generated by alternative translation initiation sites
- It's out! www.biorxiv.org/content/10.1...
- I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
- Congrats! The link isn't working for me...
- Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social! With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social www.cell.com/molecular-ce...
- Congratulations!
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- Congrats!!
- Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...
- Cool study! Congrats!!
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- Interesting looking DNA...
- The first paper from the Leppek lab is published today at @embojournal.org!! 🎉 We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues. www.embopress.org/doi/full/10....
- Congratulations Kathrin! 👏👏
- I literally asked my partner last night what part of the Titanic movie are we in right now? 🥶
- Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease. 🔗 Read here: www.nature.com/articles/s43...
- Congratulations Yifei, Jaime, and the whole team!
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- Having strong opinions on complicated topics pretty much sums up the entire internet (and the current reality)
- Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social 😊🎉🎉🎉 www.ucsf.edu/news/2025/02...
- Congratulations!! 🎉🥂
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- If your email bounces back... 😱
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- 🎉🎉🥂🥂
