Junjie Guo
Associate Professor @YaleNeuro • co-Director of Graduate Studies @Yale_INP • @YaleRNA • RNA Neurobiology • Neurodegenerative disease • Immigrant • 🐶 dad • Alum @WhiteheadInst @HopkinsNeuro @PKU1898 🏳️🌈
- Reposted by Junjie GuoBiochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
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- Reposted by Junjie GuoExcited to publish our work on how mutations in the muscle-specific ribosomal protein RPL3L drive severe heart disease. This is Part I of a larger body of work led by Michael - stay tuned for Part II on how specialized ribosomes function in normal physiology www.nature.com/articles/s44...
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- New article @natneuro.nature.com by @yaleneuro.bsky.social Suzhou Yang & @kavliatyale.bsky.social Postdoc Fellow @zhenlei.bsky.social, highlighting studies by @frattalab.bsky.social Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS @yalerna.bsky.social www.nature.com/articles/s41...
- Reposted by Junjie GuoColliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
- Reposted by Junjie GuoCheck out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
- Reposted by Junjie GuoI'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n unc.peopleadmin.com/postings/307...
- Excited to see this beautiful art, commissioned from the Chinese artist 懒云居画 (@subaiweipainting on Instagram), on this month's cover of Nature Neuroscience! @natneuro.nature.com @yaleneuro.bsky.social @yalerna.bsky.social @kavliatyale.bsky.social @wutsaiyale.bsky.social
- Our October issue is now live! www.nature.com/neuro/volume...
- Also check out this video from the artist showing the creative process: www.bilibili.com/video/BV1eKK...
- Reposted by Junjie GuoAberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD @junjieguo.bsky.social @yalerna.bsky.social @yaleneuro.bsky.social www.nature.com/articles/s41...
- Reposted by Junjie GuoAmy Arnsten, PhD, Albert E. Kent Professor of Neuroscience @yaleneuro.bsky.social, shares in an interview the current state of Alzheimer's research, where the field is going, and the importance of NIH funding to keep making progress towards treatments.
- Excited to see the work by @Yale_INP student Suzhou Yang w/ collabs @yaleneuro.bsky.social iPSC core @jdpereira.bsky.social and @mayoclinic.org @gendron_tania on #C9orf72 #ALS & #FTD finally out in @natneuro.nature.com! @wutsaiyale.bsky.social @kavliatyale.bsky.social www.nature.com/articles/s41...
- Reposted by Junjie GuoCongratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.
- Congratulations to Yale INP student in the lab, Denethi Wijegunawardana, and all other 2025 @hhmi.org Gilliam Fellows! @yaleschoolofmed.bsky.social @yaleneuro.bsky.social @yalerna.bsky.social www.hhmi.org/programs/gil...
- Riboregulation of protein folding 👀 new cool work from @christinemayr.bsky.social
- New paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...
- Excited to welcome Dr. Katie Copley as a new postdoc in our lab @yaleneuro.bsky.social! She recently completed her PhD in the Shorter lab at UPenn and did amazing work on designing small RNA chaperones to counteract TDP-43 pathology in ALS-FTD. @yalerna.bsky.social
- Reposted by Junjie GuoHello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac
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- #RNA dysfunction in aged neurons 🧠
- For those of you at #RNA2025, make sure to check out Lian-Huan's talk today on her genetic screens on the bidirectional transcription of C9 repeat expansion in ALS-FTD 🚨🚨🚨
- Reposted by Junjie GuoAmerica cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.
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- Celebrating @Yale_INP graduates👨🎓👩🎓 at the @yalegsas.bsky.social commencement 🎉🎉 @marinap63.bsky.social @schandralab.bsky.social photo by @neuralnandy.bsky.social
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- Reposted by Junjie GuoMy lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681
- Morning dog walk in Wooster square, New Haven 🌸🌸🌸
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- Congratulations to Dr. Zhen Lei in the lab, who just received a Kavli Institute of Neuroscience Postdoctoral Fellowship! @kavliatyale.bsky.social
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- 🔥🔥🔥New work from @jimmy-ly.bsky.social and @iaincheeseman.bsky.social on the numerous distinctly localized protein isoforms generated by alternative translation initiation sites
- It's out! www.biorxiv.org/content/10.1...
- Reposted by Junjie GuoI'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
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- Reposted by Junjie GuoThis isn't about Columbia - this is the White House trying to exert control over everyone and everything, using federal $ as a tool. The administration is destroying US science and ruining careers of thousands of students and researchers just to show that they are all-powerful and everyone must obey
- I literally asked my partner last night what part of the Titanic movie are we in right now? 🥶
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