Andrew S. MacDonald
Prof at Edinburgh University. #Immunologist. #Inflammation, #infection, #helminths, #allergy, #metabolism and the #microbiome.
scholar.google.com/citations?user=gcuD…
Not interested in pitchfork politics of any flavour…
- Reposted by Andrew S. MacDonald-> 𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 and 𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 for BSP 2026 in Glasgow are open! The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February. lnkd.in/eJqXD3DY
- Reposted by Andrew S. MacDonaldOn World NTD Day, we are highlighting innovative approaches to fighting NTDs. A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans. 👉Read more: bit.ly/47WdrXA
- Reposted by Andrew S. MacDonaldTwo decades of progress against neglected tropical diseases are now at risk – from funding cuts, climate change, and conflict. This World NTD Day, we must protect progress, unlock financing, and accelerate action. #WorldNTDDay #BeatNTD
- Reposted by Andrew S. MacDonald🤩 Thrilled our research is a JACI Editor's Choice! 🎉 We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬 #CRS #PrecisionMedicine #Proteomics #Immunology 🔗 ino.to/wu9XyBl
- Reposted by Andrew S. MacDonaldhard times in UK for research sector as MRC have announced a funding pause in light of the science secretary announcing an overhaul of how the agency would divide its budget which will dramatically change research....🧪🧵
- Lovely to catch up with some of the Manchester crew this afternoon, including new addition Maya 👶, for a Christmas get together 😊🎄🎅🏻 @lydiabeckeriii.bsky.social
- Reposted by Andrew S. MacDonaldIts my great pleasure to say the latest paper from our group is now out: www.mucosalimmunology.org/article/S193... Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.
- Reposted by Andrew S. MacDonaldBirds but they get spookier each time. 🎃👻 Enter if you dare...🚪
- Reposted by Andrew S. MacDonaldHere in the uk, the government has found that £1 of spending on R&D results in £8 of benefit: www.gov.uk/government/p...
- Reposted by Andrew S. MacDonaldInsights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/... #Tuberculosis
- Reposted by Andrew S. MacDonaldThank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
- NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky
- Reposted by Andrew S. MacDonaldDelighted to share this story from my PhD! 🎉 🪱
- Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
- Reposted by Andrew S. MacDonaldIn schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles. In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
- Reposted by Andrew S. MacDonald🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores! Pre-print: doi.org/10.1101/2025... R tool and tutorials: sanin-lab.github.io/OARscRNA/ @biorxiv-bioinfo.bsky.social 1/n
- Reposted by Andrew S. MacDonaldAberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
- Reposted by Andrew S. MacDonaldFantastic thread on budgeting from @labliston.bsky.social . Great advice for new (and not so new!) PIs. I would add awareness of how psychology impacts spending based on moving from low budget to high budget setting and vice versa....
- Reposted by Andrew S. MacDonaldFor our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Andrew S. MacDonaldA massive thanks to all the #EMDS2025 speakers, delegates, sponsors & @edinburgh-uni.bsky.social staff for making @emds2025.bsky.social such a success. We had a great time, we hope you did too and your travel home was smooth. Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social
- The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!
- A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo
- Reposted by Andrew S. MacDonaldA cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh
- Reposted by Andrew S. MacDonaldHeading home after a fabulous few days in Edinburgh @emds2025.bsky.social Excellent venue, amazing programme, thanks @bainlab.bsky.social @profandrewmac.bsky.social and Samanta Mariani #EMDS2025 #Macrophage #DCs ♥️
- Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025
- Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025
- Final day of #EMDS2025 opens with a fantastic talk from Will Wood - beautiful imaging of #macrophage migration following wounding, using the tractability of #Drosophila in ingenious ways to identify key chemoattractants in this process
- Reposted by Andrew S. MacDonaldWhen the PhD student gives a better talk than his promotors! 👏🏻👏🏻👏🏻 Spectacular talk from @StijnVerwaerde #EMDS2025 🤩🤩. Very cool collaboration with @bart_lambrecht team. Identification of regulatory circuits switching homeostatic regulons to type 2 inflammatory regulons in AMs
- Fantastic talk and new data from @lukeanthonyoneill.bsky.social about #mitochondrial control of #inflammation by #itaconate and derivatives in multiple settings #EMDS2025
- Really interesting talk from @chrysothemisbrown.bsky.social about ontogeny, transcriptional regulation and function of subsets of #ThetisCells, including their role in #Treg induction and oral #tolerance #EMDS2025
- Beautiful and energetic talk from @drpetercook.bsky.social about #DendriticCell uptake of and activation by #fungal spores in #allergic airway #inflammation, and metabolic requirements for this #EMDS2025
- Reposted by Andrew S. MacDonaldThank you. Very happy to discuss pur work at this amazing meeting! Great times: #EMDS2025
- Final talk pre-lunch from @mariolaks.bsky.social defining some of the key #DendriticCell subsets involved in shaping joint #inflammation vs remission, in both human and mouse #EMDS2025
- Interesting short talk from Anita Qualls about RORgt+ #APCs in oral tolerance and #Treg induction #EMDS2025
- Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025
- First talk so far about #immunometabolism at #EMDS2025 - really interesting murine and human data about mitochondrial (dys)function in #macrophages as a regulator of #inflammation, from @immunometlab.bsky.social
- Lovely talk from Samanta Mariani about embryonic #macrophages in hematopoiesis, in health and in malignancy #EMDS2025
- Really interesting talk by Barbara Schraml, showing how dietary cues at weaning can activate splenic #cDC1 to induce CTL-like effector CD8+ T cells #EMDS2025
- Day 2 of #EMDS2025 starts with a beautiful talk about lung tissue resident #alveolar #macrophage identity and the influence of #IL-33 on this, by Stijn Verwaerde from BART Lambrecht’s lab.
- Reposted by Andrew S. MacDonald#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).
- I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
- A fascinating education in #LangerhansCell biology and function from Clare Bennett, as well as a closing advert for the 18th International #DendriticCell symposium in San Diego next year #EMDS2025 #DC2026
- Lots of exciting new data from @esegura-lab.bsky.social revealing an important role for Aryl Hydrocarbon receptor #AhR in promotion of wound healing my #macrophages #EMDS2025
- Fascinating (and disturbing!) presentation about the impact of ingested microplastics on liver macrophages by @mariafviola.bsky.social #EMDS2025
- Really interesting story from @gastrogrj.bsky.social - murine and human data showing that #activin signaling in intestinal #monocytes is key for epithelial barrier repair during intestinal #inflammation #EMDS2025
- Lovely talk from Bill Agace about the regional diversity of #dendriticcells in human intestines, in health vs Crohn’s disease #EMDS2025
- Beautiful discovery science from Catherine Robin about blood resident #macrophages - including some gorgeous imaging in #zebrafish #EMDS2025
- A fantastic talk about liver monocytes and macrophages by @martinguilliams.bsky.social kicks of #EMDS2025 - beautiful application of multiple cutting edge technologies to understand cel-cell interactions in tissues
- #EMDS2025 begins! Looking forward to a few days of exciting science about all things #macrophage, #dendriticcells and #monocytes in beautiful Edinburgh
- Some very important preparation for #EMDS2025 completed! #SMWS membership renewed. Looking forward to some great science, meeting old friends and making new ones in the week to come 🧪 🥃 🏴 😊
- Reposted by Andrew S. MacDonald📣 Journal Editors at EMDS2025:Scotland Edition @gaiajexpmed.bsky.social, Deputy Editor @jem.org, will be in Edinburgh at #EMDS2025 next week. Reach out to her to discuss your work. Also, check out the Special Collection @jem.org on #macrophage & #dendriticcells @efis-immunology.bsky.social
- Our new collection highlights recent advances in our understanding of #macrophages & #dendriticcells, and their roles in #infection, #allergy, #cancer, #neuroinflammation, & #neurodegeneration. Read new research to accompany next week's #EMDS2025! rupress.org/jem/collecti... @emds2025.bsky.social
- Reposted by Andrew S. MacDonaldOur new collection highlights recent advances in our understanding of #macrophages & #dendriticcells, and their roles in #infection, #allergy, #cancer, #neuroinflammation, & #neurodegeneration. Read new research to accompany next week's #EMDS2025! rupress.org/jem/collecti... @emds2025.bsky.social
- Reposted by Andrew S. MacDonaldSave the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟
- Reposted by Andrew S. MacDonaldLooking to hire a postdoctoral associate to examine how antibiotics frequently fail in vivo and identifying new ways to make them work better. unc.peopleadmin.com/postings/306...
- Reposted by Andrew S. MacDonald📣 Journal Editors at #EMDS2025 @claireolingy.bsky.social , Senior Editor at #Science #Immunology @aaas.org , will be at EMDS2025, so be sure to reach out to her to discuss your work. @efis-immunology.bsky.social @britsocimm.bsky.social
- Reposted by Andrew S. MacDonaldSpeaker Highlight - Barbara Schraml What controls functional programming of #dendritic cells? Join us at #EMDS2025 to hear from @barbaraschraml.bsky.social about their recent work on DC diversity. www.emds2025.com @britsocimm.bsky.social @efis-immunology.bsky.social [Background photo: Yao Fu]
- Reposted by Andrew S. MacDonaldHonoured to be opening EMDS2025!!! What a superb program! See you all in Scotland 🤩🤩🤩🤩🤩🤩
- Reposted by Andrew S. MacDonaldThis week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover! scim.ag/3UqRrA6
- Reposted by Andrew S. MacDonaldYou asked, we listened! We have had multiple requests for late breaking abstracts for #EMDS2025. So, we have managed to squeeze in 15 more opportunities for poster presentation. Submit your abstract at www.emds2025.com - first come, first served. Deadline: 22.08.25 (or when 15 slots allocated!)
- Reposted by Andrew S. MacDonaldVaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans | Science www.science.org/doi/10.1126/...
- Reposted by Andrew S. MacDonaldSuper excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...
- A real pleasure to be a part of this beautiful new study on T cell responses in repeat controlled human infection vs natural infection with #schistosomes, spearheaded by @emmahoulder.bsky.social with many wonderful colleagues #helminths #ImmunoSky #IDSky 🪱 🧪 www.nature.com/articles/s41...
- Reposted by Andrew S. MacDonald[1/7] How close are we to a schistosomiasis vaccine? With help from an #MSCA fellowship and support from Batavia Biosciences, I spent 6 months reviewing 100+ pre-clinical studies on S. mansoni vaccines. Here's what we found: 📄 doi.org/10.1371/jour...
- Reposted by Andrew S. MacDonald🚨 Postdoc alert! Our former committee member @macleanlab.bsky.social is looking for a postdoc to work on Toxoplasma metabolism in his lab. Great opportunity to do cool science in a beautiful city! 🧪🤝
- 📣 Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️ elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
- Reposted by Andrew S. MacDonaldSpeaker Highlight - Yasmine Belkaid We are delighted that @belkaidlab.bsky.social, President of @pasteur.fr, will deliver the Keynote Lecture of Day 1 of www.emds2025.com - I'm sure it will be a tour de force! @britsocimm.bsky.social @societymucosalimm.bsky.social [Background photo:Chris Close]
- Reposted by Andrew S. MacDonaldSpeaker Highlight - Martin Guilliams Can't wait for @martinguilliams.bsky.social from @viblifesciences.bsky.social to open www.emds2025.com and hear about how in vivo CRISPR and spatial 🔬 is uncovering molecular dialogue in the liver. @britsocimm.bsky.social [Background photo:Sam Sills]
- Reposted by Andrew S. MacDonaldThe July issue of #Science #Immunology is out now! This week: • Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy! • Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut! New content each week! www.science.org/toc/sciimmun...
- Reposted by Andrew S. MacDonaldJoin us at @edbookfest.bsky.social on Wed 13 August for 'Future Library' 📗, a project based in Norway. This event, sponsored by Edinburgh Futures Institute, features Future Library's Anne Beate Hovind. 📍 Edinburgh Futures Institute 🗓️ 13 August | 8:15pm – 9:30pm 🎟️ Tickets £15.50: edin.ac/477bXeC
- Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...
- Reposted by Andrew S. MacDonaldA big thank you to the sponsors of #EMDS2025 - they have allowed us to put together an awesome programme. Check it out here: www.emds2025.com Still a couple of slots to sponsor if any commercial friends want to be at a fantastic meeting in 🏴. Registration open, but numbers limited!
- Reposted by Andrew S. MacDonaldWow! 170 abstracts submitted - thanks for the enthusiasm 🙌🏻 These were scored by a 30+ panel from across 🇪🇺. Check your inbox in the coming week for outcomes - talk vs. poster. Still time to apply for awards/services below. Only 3wks to Early Bird deadline - 1st Aug. Oh and the social > ceilidh 👇🏻
- Just over 1 month to the Early Bird Registration for #EMDS2025. Remember you can apply for: 🏆 Young Investigator Award ✈️ Travel Awards 🚼 On site creche service Full details & programme at www.emds2025.com [Background photo: Tricia Malley & Ross Gillespie]
- Reposted by Andrew S. MacDonaldStimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
- Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪 dx.plos.org/10.1371/jour...
- Reposted by Andrew S. MacDonald🚨 We're hiring! 🚨 Join the Jones Lab at the University of Glasgow, as a Research Assistant working on gut immunology & IBD 🧫🧬 Be part of a rapidly growing team working with me, @glasgowgutscience.bsky.social and @bainlab.bsky.social 🗓️ Closing date: 12 June 🔗 www.jobs.ac.uk/job/DNC531/r...
- Reposted by Andrew S. MacDonald🚨 Abstract Deadline - Friday 30th May There are 10 days left to submit your abstract for EMDS2025. We have >20 selected talk slots - so submit an abstract today! All details & programme: www.emds2025.com @britsocimm.bsky.social @societymucosalimm.bsky.social @cytokinesociety.bsky.social
- Reposted by Andrew S. MacDonald🚨 New McSorley lab paper just out in Cell Reports! Very happy to see this published - it has been a lot of work, and its turned into a really nice story. In it, we show that HpARI+HpBARI can be used as vaccines Tutorial thread below (1/16): www.sciencedirect.com/science/arti...
- Reposted by Andrew S. MacDonaldAfter a period of silence, delighted to share our latest work has come out as a pre print. Check it out. Huge thanks to the amazing efforts of co-authors and most importantly the generosity of the patients in providing samples. www.medrxiv.org/content/10.1...
- Reposted by Andrew S. MacDonaldWow! Amazing response in the first few days of registration opening for www.emds2025.com Be sure to register early to avoid disappointment. 🚨 Abstract deadline is FRIDAY 30th MAY (Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
- 🚨 REGISTRATION NOW OPEN!!! Head to www.emds2025.com to register and submit your abstracts. Full programme is now available. NB: Spaces are limited, so don't delay, register today! @britsocimm.bsky.social @efis-immunology.bsky.social @societymucosalimm.bsky.social @natrevimmunol.nature.com
- Reposted by Andrew S. MacDonald🚨 REGISTRATION NOW OPEN!!! Head to www.emds2025.com to register and submit your abstracts. Full programme is now available. NB: Spaces are limited, so don't delay, register today! @britsocimm.bsky.social @efis-immunology.bsky.social @societymucosalimm.bsky.social @natrevimmunol.nature.com
- This made me chuckle… #Immunosky 🧪
- Reposted by Andrew S. MacDonaldThe spring EIG session is coming this Thursday on 1st of May. Please join us from 13:30 in @edinuni-irr.bsky.social IRR South seminar room 1.05 for fantastic talks by Dr. Elizabeth Mann, Dr. Tovah Shaw and Prof. Hamida Hammad. See you there!
- Reposted by Andrew S. MacDonaldSpeaker Highlight - Bart Lambrecht Interested in #alveolar #macrophages (AMs)? Then do not miss Bart Lambrecht from @viblifesciences.bsky.social at EMDS2025 - he'll discuss recent work showing how AMs can become multi-nucleated giant cells! @britsocimm.bsky.social Photo by Sam Sills
