Emma Houlder
Researcher at LUMC.
Immunology, schistosomiasis, vaccines.
- In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles. In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
- Thanks of course to all my co-authors (Uganda, Netherlands and UK) and funders!!!!!!!
- [1/7] How close are we to a schistosomiasis vaccine? With help from an #MSCA fellowship and support from Batavia Biosciences, I spent 6 months reviewing 100+ pre-clinical studies on S. mansoni vaccines. Here's what we found: 📄 doi.org/10.1371/jour...
- [2/7] A few candidates—like Smp-80 and Cathepsin B—stood out, with >90% protection in some studies. But the median efficacy across all candidates was around 35%.
- FIRST POST! Fungi drive asthma, but does this require germination? We show A. fumigatus spores activate DCs after 3hrs of swelling, promoting airway allergy. Antifungal itraconazole limits swelling & reduces allergic inflammation. Check it out: doi.org/10.1016/j.ja... @drpetercook.bsky.social 👩🔬
