Gina DeNicola
Redox biology and cancer metabolism @ Moffitt Cancer Center. Views my own.
- Reposted by Gina DeNicolaVery helpful methods and protocol! www.sciexplor.com/articles/fos... Great work @ginadenicola.bsky.social and team!
- Reposted by Gina DeNicolaExcited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: www.sablesys.com/metphys-the-...
- Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
- This project started when our jugular surgeon left research. After initial panic, we wondered “can we use the tail vein?” But we would need anesthesia, is it really that bad for metabolism?
- YES! Just 2 hours of isoflurane profoundly altered metabolism. Glycolysis/TCA ↓, sulfur amino acids ↓, acylcarnitines ↓, while BCAAs ↑, ketones ↑, fatty acids ↑—suggesting complex metabolic deregulation. These pool size changes compromise flux interpretation.
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View full threadA practical, anesthesia-free platform for in vivo metabolic tracing! Preprint: doi.org/10.64898/202.... Questions? Reach out—happy to share protocols!
- Got up at 5AM today to do the Miles for Moffitt 10K with Basma from my lab. Success!
- Exciting!
- Online now! Online now! An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels #chembiol
- The best compliment 😁
- I now like metabolomics thanks to @ginadenicola.bsky.social interesting talk! Thanks for visiting MCB at Baylor College of Medicine
- Reposted by Gina DeNicolaWe have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
- Reposted by Gina DeNicolaJob alert 📣 Our faculty looks for a Junior Professor W1 with tt to W2 in Membrane Biology! We are looking for #ECRs working on membrane biogenesis,contact sites,composition & other aspects of membranes in 🌱 and other organisms! DM me if you need more details! jobs.ruhr-uni-bochum.de/jobposting/f...
- Reposted by Gina DeNicolaMy department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438 @dartmouthbcb.bsky.social @futurepislack.bsky.social
- Reposted by Gina DeNicolaA wonderful new opportunity - for both Rising Stars and established Research Leaders - to open a research lab in Ireland 🇮🇪🧪 Up to 3.25 million euro in support 🤩 #GlobalTalentIreland #Research #Ireland
- Reposted by Gina DeNicolaFinal call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
- Reposted by Gina DeNicolaWe have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
- Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
- Reposted by Gina DeNicolaThanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social
- Hot science and hot temperatures at the FASEB Ferroptosis conference start tonight. Seriously the highs are 110F here 🥵 but it's beautiful!
- Reposted by Gina DeNicolaTo distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨
- Reposted by Gina DeNicolaIt's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃
- Reposted by Gina DeNicolaIMPORTANT IMPORTANT IMPORTANT IMPORTANT Please watch the workshop video and COMMENT by 5:00 Monday 7/14 This is the source of the "no more model organism only grants in NIH-funded research" decree.
- New work from @karrethlab.bsky.social!
- FRA1 drives melanoma metastasis through an actionable transcriptional network biorxiv.org/content/10.1101/202…
- Reposted by Gina DeNicolaFRA1 drives melanoma metastasis through an actionable transcriptional network biorxiv.org/content/10.1101/202…
- Reposted by Gina DeNicolaUnravelling cysteine-deficiency-associated rapid weight loss www.nature.com/articles/s41...
- Great work by @rushika-perera.bsky.social!
- PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer www.nature.com/articles/s41... Massive congratulations to @rushika-perera.bsky.social Lab!!
- Reposted by Gina DeNicolaREMINDER.....REMINDER......REMINDER 3 DAYS LEFT TO COMMENT ON SCHEDULE F 1/n
- Reposted by Gina DeNicolaOur latest ‘Cell Scientist to Watch’ is Samantha Lewis. We caught up with Samantha to discuss her career path, the challenges for working on the ‘neglected’ mitochondrial genome and the exciting new frontiers in mitochondrial research. journals.biologists.com/jcs/article/... #JCSMitoSI
- So excited for this!
- Abstracts are being accepted for #FOLSCR, a brand-new conference exploring a new form of cell death. With @ginadenicola.bsky.social and @brentstockwell.bsky.social, this may be one of FASEB's biggest new conferences. Submit your research by June 1 and save your space: buff.ly/HB3PDmS
- MALDI imaging of lipids, metabolites and glycans all on the same section! From Ramon Sun and colleagues. www.nature.com/articles/s41...
- Reposted by Gina DeNicolaIn their Tools & Resources article, Corey Cunningham @cnfxc.bsky.social Jared Rutter @rutterlab.bsky.social @uofubiochem.bsky.social & team present their dual-purification system to isolate mitochondrial subpopulations. journals.biologists.com/jcs/article/... #JCSMitoSI #OpenAccess #Mitochondria
- 🚨New paper alert! Led by former undergrad Amanda Sherwood @tophinogenesis.bsky.social (now PhD student at Northwestern), Amanda asked whether the glutathione or thioredoxin systems are necessary for NRF2's tumor-promoting effects in the lung. www.sciencedirect.com/science/arti...
- NRF2 regulates both glutathione and thioredoxin recycling via glutathione reductase (GSR) and thioredoxin reductase 1 (TXNRD1), which have unique and overlapping disulfide targets. Amanda wondered whether these enzymes would be redundant or would they both be required for tumorigenesis?
- Amanda found GSR deletion impaired tumor initiation, regardless of NRF2 status, while TXNRD1 deletion impaired progression to the adenoma stage specifically in NRF2 mutant tumors. This suggested they had non-overlapping roles at these stages.
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View full threadI am so very proud of Amanda for what she has accomplished in this study, of manuscript she wrote, and of her fearlessness in science. She is a superstar 🌟 I would also like to give a shoutout to our newest lab member Basma Yasseen who carried the revisions over the finish line 💪
- That's a wrap on the 2025 Cancer Metabolism Showcase. With everything going on it was so great to hear a fantastic career keynote from Jeff Rathmell and awesome talks and posters from students and postdocs! Hats off to @harrislab.bsky.social for running the show.
- thanks to co-organizers @rushika-perera.bsky.social @muirlab.bsky.social @lydiafinley.bsky.social Dan Tennant, Dirk Brenner and Kristin Brown.
- also thanks to all the workshop panelists, including @lyssiotislab.bsky.social @airdlab.bsky.social @colofflab.com @naama-kanarek.bsky.social @marasherman.bsky.social @louisefets.bsky.social @jcmunger.bsky.social @faubert.bsky.social @kristabledsoe.bsky.social ...
- ...Michele Hartsough, Nicole Lopanik, Thekla Cordes, Gloria Asantewaa, Christina Adams, Tim Wang, Feroza Choudhury, Brad Mills, and Brad Smith! See you next year!
- Reposted by Gina DeNicolaReminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. shorturl.at/QA6T1
- Reposted by Gina DeNicolaOur latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2
- Reposted by Gina DeNicolaThe Department of Human Genetics at the University of Utah is sponsoring the Rising Stars in Genetics and Genomics symposium! - We are seeking nominations bu June 1. - September 18-19, 2025 - Please share with the star postdocs that you know. docs.google.com/forms/d/e/1F...
- Reposted by Gina DeNicola#FOLSCR is a new conference exploring all aspects of a form of cell death that results from iron accumulation and lipid peroxidation. Hear keynotes @ginadenicola.bsky.social and @brentstockwell.bsky.social with organizers Scott Dixon and @olzmannlab.bsky.social. Save your space: buff.ly/MmJsYQq
- Reposted by Gina DeNicolaACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
- Reposted by Gina DeNicolaTargeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids: Cell Metabolism www.cell.com/cell-metabol...
- Reposted by Gina DeNicolaDiscovery of a gut-joint axis pathway and the salutary role of GLP-1 for "wear and tear" arthritis. New @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
- Reposted by Gina DeNicolaI’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
- Reposted by Gina DeNicolaThe time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism researchhttps:// www.nature.com/articles/s42255-025-01237-6
- Reposted by Gina DeNicolaIn a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more in this week's issue: scim.ag/3FA3Ygq
- Abstracts are due TOMORROW! Please share!
- 📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨 Registration free! Speakers chosen from abstracts and non-faculty only! Amazing poster session and workshops! Sign up today at: www.cancermetabolismshowcase.org
- What's better than spatial metabolomics? Spatial metabolomics in 3D! New from Ramon Sun and colleagues, a 3D map of the brain metabolome using AI, with an interactive database to explore. www.nature.com/articles/s42...
- If Ramon publishes any more papers this year, I'm going to have to start charging him PR fees 😜
- Reposted by Gina DeNicola1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...
- Fascinating work from MALDI master Ramon Sun and collaborators on glycogen metabolism in NSCLC. A real tour de force and such beautiful images 😍 www.nature.com/articles/s42...
- New toy installed and everyone trained this week!
- Reposted by Gina DeNicolaPlease share: @delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group. They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...
- Reposted by Gina DeNicolaNIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)
- Reposted by Gina DeNicolaExcited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.
- Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation biorxiv.org/content/10.1101/202…
- "Here, using 18 single, double and triple whole-body and tissue-specific knockout and mutant mice..."
- Reposted by Gina DeNicolaBREAKING: Federal judge in Boston broadens block on Trump's NIH grant 15% overhead limit (indirect cost rates) to all recipients nationwide. Doc: www.documentcloud.org/documents/25... #TROpalooza ain't done
- Reposted by Gina DeNicola#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments
- Reposted by Gina DeNicolaHere's a good infographic from AAUP on what indirect costs fund. It's a lot of important things!
- Study sections are back on this week
- Reposted by Gina DeNicolaWe are looking for PhD students and/or postdocs that want to join us to study the metabolism of metastasizing cancer cells with cutting-edge spatial and single cell technologies. fendtlab.sites.vib.be/en
- Reposted by Gina DeNicolaI’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field. www.cancermetabolismshowcase.org
- Our lab's first paper of 2025. With @christhechang.bsky.social we find that NRF2 active lung cancer cell lines suppress labile copper and are vulnerable to copper chelation (1/3).
- Activity-based sensors identify cuproplasia and ferroplasia as druggable metal vulnerabilities in cancer! With @ginadenicola.bsky.social and Adam Renslo, we profile cancer cell lines to find those sensitive to Cu or Fe chelation www.pnas.org/doi/10.1073/... www.pnas.org/doi/10.1073/... #chemsky 1/n
- Copper is an oxidizer (though less appreciated than iron) so it's logical to suppress labile copper under oxidative stress to prevent cysteine oxidation and ROS generation; with constitutive NRF2 activation, however, this becomes a vulnerability (2/3).
- Congrats to Marco Messina, Laura Torrente, and Adrian Pezacki on this work! Thanks to all our collaborators, especially Odette Verdejo-Torres, Teresita Padilla-Benavides, Nate Ward and @bradylabupenn.bsky.social on our end (3/3).
- Reposted by Gina DeNicolaExcited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15
- I'm looking for a serum-free culture media for lung cancer cells that's defined, but the commercial options seem to be proprietary. Has anyone replaced FBS with growth factors and/or ITS and had their cell lines grow well in these conditions?
- Congrats to @timwitney.bsky.social and team on this study!
- 🚨Out today in @natureportfolio.bsky.social Nature Communications: Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography🍾 www.nature.com/articles/s41... In this paper, we show that [18F]FSPG-PET imaging is a sensitive marker of NRF2/KEAP1 activating mutations...
- Reposted by Gina DeNicolaI have initiated this #StarterPack with #RedoxBio researchers. Feel free to suggest other users, or yourself, to be included! go.bsky.app/UoVRtXpat://did:plc:zvxmrzhwgfvi5l3vkhnp2lhn/app.bsky.graph.starterpack/3lb3kcekvgd2l
- Pies are ready for Thanksgiving!
- Reposted by Gina DeNicola#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAWat://did:plc:mwufg2moeac7xpkjybzlzogd/app.bsky.graph.starterpack/3lbnhrzusmf26
- Reposted by Gina DeNicolaFirst Princeton paper! Activity-based sensing plus narrow Raman signatures enable multiplex copper imaging, revealing crosstalk between high antioxidant response element NRF2 activation and low labile Cu in cancer. Fun project with Wei Min’s lab at Columbia! #chemsky pubs.acs.org/doi/10.1021/...
- Reposted by Gina DeNicolaExcited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. www.biorxiv.org/content/10.1...
- Congratulations to Dr. Janine DeBlasi (class of '23) who won the Outstanding Dissertation award from USF! Janine was selected for this award from PhD students across all the graduate colleges. A huge accomplishment!
- I renewed my passport online. It took less than a week from application to mailbox!
- Reposted by Gina DeNicolaJoin us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
- There is no happier message to receive than from a PhD student who just passed her qualifying exam. Congratulations to Lejin Sun!
- Reposted by Gina DeNicolaat://did:plc:mklo35zasunpbla4ipbtfafk/app.bsky.graph.starterpack/3lau326bdbh2n
- Reposted by Gina DeNicolaat://did:plc:7ylcctguchtf7m5nyccopvsu/app.bsky.graph.starterpack/3lajrl3wone22
- Reposted by Gina DeNicolaI'm going to start working on this, and will add to it as more major media outlets join Bluesky. I expect the pace to pick up very soon and very significantly. Major media has let us down significantly over the last ten years, but it's still vital to know what's being reported. go.bsky.app/2JyEju6at://did:plc:vpfavbhwv4okwh6ydgp5uxf6/app.bsky.graph.starterpack/3lavcdjciqh2y
- Reposted by Gina DeNicolaJoin us in May, 2025 for a conference on Metabolic and Nutritional Control of Development and Cell Fate - one of the most interesting and fast-moving areas in cellular metabolism, with great relevance to disease: www.keystonesymposia.org/conferences/.... -RJD
- Reposted by Gina DeNicolaPeople working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
- Progress on drugging NRF2. www.biorxiv.org/content/10.1...
- Congratulations to Dr. Janine DeBlasi on a successful thesis defense! Our lab's first PhD. A big milestone!
- Reposted by Gina DeNicolaCool editorial opening for a Team Manager at Nature Communications; they are looking for someone to lead a team of 4-8 editors at the interface of the physical and life sciences to handle multidisciplinary papers. Closing date: Sept 4th Location: London or Berlin (Reskeets appreciated!)
