Mara Sherman
Scientist at Memorial Sloan Kettering Cancer Center in NYC. “The greatest gift you ever give is your honest self.” - Fred Rogers
- Reposted by Mara ShermanToday in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...
- Reposted by Mara Sherman
- Reposted by Mara ShermanWe are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—
- Sequence and structural determinants of efficacious de novo chimeric antigen receptors biorxiv.org/content/10.64898/20…
- Reposted by Mara ShermanHeads up to any pancreatic cancer research that either had their R01 yanked or missed funding due to the newly restrictive paylines in 2025 (specifically anyone who scored 15%ile or below, but didn't get funding). media.pancan.org/rsa/2026/Pan...
- Reposted by Mara ShermanThrilled to share our new paper published in Cancer Research (@theaacr.bsky.social), led by outstanding work from Priyanka Gupta in our lab. Our study uncovers how stromal aging fundamentally reshapes pancreatic ductal adenocarcinoma (PDAC) biology. aacrjournals.org/cancerres/ar...
- Reposted by Mara ShermanSubmit an abstract by October 1 for the AACR Special Conference on Cancer Evolution (December 4-6; Albuquerque), chaired by Mariam Jamal-Hanjani, Kenneth J. Pienta, and Mara H. Sherman and held in association with #AACRCEWG. buff.ly/meDBvm2 #AACRevol25 @marasherman.bsky.social
- Reposted by Mara ShermanOur paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...
- Reposted by Mara ShermanNow accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer. bit.ly/3WUiuo1
- Reposted by Mara ShermanHow can we reawaken the body’s own anti-viral defenses to fight brain cancer? Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏 #BrainTIME 🧠🦠🧪 🧵 www.sciencedirect.com/science/arti...
- Reposted by Mara ShermanThrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...
- Reposted by Mara ShermanMy recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
- Reposted by Mara ShermanMechanical confinement governs phenotypic plasticity in melanoma www.nature.com/articles/s41...
- To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨
- Excited to share work published in @cp-cancercell.bsky.social by @yijuan.bsky.social showing that macropinocytosis inhibition drives myCAF-to-iCAF conversion, enhancing therapeutic responses in pancreatic cancer. Thank you to our collaborators that contributed! www.sciencedirect.com/science/arti...
- Reposted by Mara Shermanwww.nature.com/articles/s41... NNMT inhibition in cancer-associated fibroblasts restores antitumour immunit
- Reposted by Mara ShermanExcited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
- Reposted by Mara ShermanNew paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...
- Reposted by Mara ShermanAlright! Took me way too long but I’m here and trying to re-engage. The world is burning but the #BAPlab is not! Up next! In two weeks our lab twins Garima Baral and Clair Pfeffer will defend their Ph.D.s 🔬I may burst from excitement or stress, one of the two. @cancer-inst-purdue.bsky.social
- Reposted by Mara Sherman25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.
- Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨
- I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
- Reposted by Mara ShermanI am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer. www.biorxiv.org/content/10.1...
- Reposted by Mara ShermanRegistration is OPEN for the next edition of The Tumour Ecosystem! 🎉 Taking place next March in Bergamo, this conference will cover the latest advances in research of the tumour microenvironment. Learn more and register now: eacr.org/conference/t...
- Reposted by Mara ShermanCheck out this seminal study @theaacr.bsky.social by the one and only @marasherman.bsky.social aacrjournals.org/cancerdiscov... & the commentary about its importance to gain understanding on the inherent tumor-suppressive #PancreaticCancer #TME (by yours truly) aacrjournals.org/cancerdiscov...
- Reposted by Mara ShermanLast night, past Mark Foundation Emerging Leader Award winners gathered with this year’s recipients, @marasherman.bsky.social , @liron1bar-peled.bsky.social, Kai Kessenbrock, Ansu Satpathy, and Dan Wahl, to celebrate seven years of this transformational program. #MarkSymposium
- Reposted by Mara ShermanThis is very much fitting, and exciting, for my first Blusky post 🤩 Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD_AACR!! t.co/vmq8ZyQ3KV
- Reposted by Mara Sherman1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...
- Check out this beautiful NIH-funded study identifying targetable mediators of peritoneal metastasis. Important work - congrats Ganesh lab!
- #preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud www.biorxiv.org/content/10.1...
- Reposted by Mara ShermanDeep and thoughtful reporting on the crises of the NIH funding and review blocks. Share locally, share widely. And make sure your reps know! www.washingtonpost.com/science/2025...
- Reposted by Mara ShermanThe Stand Up For Science website has been updated. Find your local protest site! March 7! Get out there! standupforscience2025.org
- Reposted by Mara Sherman2. The U.S. Senate HELP Committee is run by LA Senator Bill Cassidy and has HHS oversight. Call his committee and tell his staff how this Federal Register 'end run' around Congress and the Courts is sowing chaos in science progress. Please call his office TOMORROW: 202-224-6770 and
- Reposted by Mara ShermanMake sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...
- Reposted by Mara ShermanTrying to focus on inspiring activities… join us for 3rd annual SoCal Metabolism Symposium this year hosted by @petemullen.bsky.social at USC in Los Angeles. gero.usc.edu/event/third-...
- Reposted by Mara ShermanIf you could tell the general public 3 things about how science has been impacted this week, what would they be? (I’m making a flyer.)
- Reposted by Mara Sherman1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
- Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
- Big thanks to our fantastic collaborators @mskcancercenter.bsky.social @ohsuknight.bsky.social @stanfordmedicine.bsky.social. Looking forward to next steps!
- Reposted by Mara ShermanIf you think the NSF is a waste of government money, you should stop using any technology created using NSF-funded research. Like cell phones. Or the Internet
- Reposted by Mara ShermanGetting rid of diversity supplements is devastating. I run a seminar series for up and coming scientists. One thing I can do to help is to ensure this series represents the full diversity of the scientists in our field. Pass this along and help us make that possible. bsky.app/profile/mike...
- And the funding announcement for diversity supplements now has been updated to expire today. Supplements are so important to the careers of junior scientists. This is crushing for post docs and early career faculty grants.nih.gov/grants/guide...
- Reposted by Mara ShermanI’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field. www.cancermetabolismshowcase.org
- Reposted by Mara Sherman🥳🥳 Very happy to see Eloise Lloyd et al finally published!! 🥳🥳 Congrats to the whole lab! 💜 A beautiful study looking at how distinct #genetics of malignant cells shape #PDACprogression, #MalignantStromalCrosstalk and #TherapyResponse. #OnlineFirst version👇 aacrjournals.org/cancerres/ar...
- Reposted by Mara Sherman📢Announcing The Mark Foundation 2025 Emerging Leader Award winners! 📢 These 5 outstanding early-career scientists will receive a total of $3.75M to pursue projects with the potential to transform cancer research. We can’t wait to see what they achieve! themarkfoundation.org/2025/01/the-...
- Reposted by Mara ShermanVery much looking forward to the 2025 GRC on Pancreatic Diseases - June 15-20 (www.grc.org/pancreatic-d...). We have (I think) a brilliant lineup of speakers and discussion leaders (🤩). Hope to see you there so please sign up/register (and RT - if thats the correct term here)
- Check out this brilliant new assay from the Lareau lab for isolation of rare cells by RNA-based cytometry for transcripts of interest, compatible w downstream sc genomics! ✨
- Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n www.nature.com/articles/s41...
- Reposted by Mara ShermanInterested in immunology and looking to gain research experience before applying to graduate or medical school?Join us! We're hiring a research technician general-mskcc.icims.com/jobs/83021/r...
- Reposted by Mara Sherman⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development! keysym.us/KSMetabDev25 The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
- Reposted by Mara ShermanNew year, new beginnings! 🎉 The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social! We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity. #NewPI #AcademicSky #WomenInSTEM (1/2)
- Reposted by Mara Sherman🔬 We’re Hiring! 🧪 The Single-cell Analytics Innovation Lab @mskcancercenter.bsky.social is expanding and looking for Junior Research Technician! Join our team based in NYC to work on cutting-edge single-cell & spatial genomics methods in collaboration with leading research labs.
- Reposted by Mara Sherman🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...
- Reposted by Mara ShermanIn case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy. www.biorxiv.org/content/10.1...
- Reposted by Mara ShermanExcited to share our latest by graduate student Filio Karakousi where we find that IFNg acts as a metabolic switch to prune tumor-associated lymphangiogenesis and unlink immune surveillance and metastasis www.biorxiv.org/content/10.1...
- Reposted by Mara ShermanI'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities. www.nature.com/articles/s41...
- Reposted by Mara ShermanThe MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs careers-fhcrc.icims.com/jobs/28757/p...
- Reposted by Mara Sherman“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.” www.researchamerica.org/2023-oped-us...
- Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019. But come January, NIH may face a wrecking ball nytimes.com/2024/12/01/h...
- Reposted by Mara Sherman1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
