Sara MaciasRNA
Molecular biologist | Wellcome Trust Senior Fellow | antiviral defence | RNA processing | interferons | transposable elements | small RNAs | embryonic development
Free Palestine 🍉
- Reposted by Sara MaciasRNARegistrations are now OPEN! Join us in Newcastle for the “RNA in Physiology and Disease” conference, an international meeting bringing together world-leading RNA biologists and emerging researchers. Early bird deadline: 1 May Abstract deadline: 30 June Register now: genetics.org.uk/events/rna-i...
- Reposted by Sara MaciasRNASome initial reactions to the 'published on a Sunday afternoon' letter from the CEO of UKRI. 🧵 www.ukri.org/news/open-le...
- Reposted by Sara MaciasRNAWe need to be shouting about the effects of this on junior researchers from the roofs, writing to our MPs. We are risking a "missing generation" of researchers.
- Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky
- Reposted by Sara MaciasRNAHave a look at this fantastic meeting and save the date! The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK. genetics.org.uk/events/rna-i...
- Amazing talk by Kat Gordon in our group on Dicer I syndrome. Picture contains the leading ‘heads’ of the RNA field in the UK Dimitris Lagos, Nick Proudfoot and Alena Shkumatava #RNAUK26
- So much work still to do to break the glass ceiling! Analysis of millions of biomed & life science articles reveal that female-authored articles spend longer under review than comparable male-authored ones @plosbiology.org 🧪 plos.io/4658FZN
- Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩 rdcu.be/eWMfA
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- In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)? In collaboration with @herassr.bsky.social and @heick.bsky.social labs www.biorxiv.org/content/10.1...
- Reposted by Sara MaciasRNAHappy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social www.biorxiv.org/content/10.1...
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- Reposted by Sara MaciasRNAOur latest paper is out in NAR! 🥳 In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates. Read: academic.oup.com/nar/article-...
- Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC Thanks to all the coauthors and funders academic.oup.com/nar/article/...
- Reposted by Sara MaciasRNAI'm so excited about @saramaciasrna.bsky.social invitation to visit the Institute of Immunology and Infection Research, @edinburgh-uni.bsky.social on the 5th of February. I will be sharing our latest research on #RNAmodifications in #cancer
- RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development. #crispr #iclip #omics Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas www.findaphd.com/phds/project...
- Important reading - unfortunately not open access
- Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/
- Reposted by Sara MaciasRNAAnd since we're here... 🥼 Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬 More details via www.imb.de/jobs Application deadline is 5 January 2025 #sciencejobs #resilience #biostatistics
- Had an amazing time visiting King’s college dept of Infectious diseases. Thanks @Rocio Nunez and @Hannah Mischo for the hosting and great tapas with @charlotte odendall …and a beautiful early morning walk by the river!
- Reposted by Sara MaciasRNAHappy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)
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- This is so good! Thanks @tillysscott.bsky.social
- And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵
- Great discussion at the Genetics Society conference 🧬
- Next up is @SaraMaciasRNA discussing how DGCR8 acts as a gatekeeper of the interferon response by preventing cytoplasmic TE-dsRNA accumulation #GStransposons
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